Results 181 to 190 of about 57,189 (285)

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source

The EvIDHence study: real-world treatment patterns and safety outcomes in mutant and wild-type <i>IDH1</i> cholangiocarcinoma before availability of mIDH1 inhibitors. [PDF]

ESMO Gastrointest Oncol
Sahai V, Valle JW, Fares N, Javle M, Ghanem I, Cerdà P, Rapposelli IG, Jimenez IG, Gonzalez-Carmona MA, Hollebecque A, Cid RP, Palmer DH, Vera R, Casadei-Gardini A, Melisi D, Blanc JF, Perkhofer L, Lamarca A, Gharbi H, Manuel-Minguez V, Robert R, Rimassa L.   +21 more
europepmc   +1 more source

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Resistance to venetoclax has become a critical bottleneck limiting its long‐term clinical benefits. A thorough understanding of the underlying resistance mechanisms and the development of novel strategies to overcome resistance are central to improving survival outcomes in elderly AML patients. Abstract To date, the treatment of acute myeloid leukaemia
Jinlin Zhang, Jile Liu, Mohan Zhao, Xiaoyu Zhang, Linlin Liu, Mengnan Li, Changze Cao, Rui Zhang, Mingfeng Zhao   +8 more
wiley   +1 more source

The acetylation mechanism and engineering strategy of isocitrate lyase for optimizing biosynthesis in <i>Escherichia coli</i>. [PDF]

Synth Syst Biotechnol
Jia R, Wang J, Zhang Y, Xian M, Qi Q, Liu M, Zhao G.   +6 more
europepmc   +1 more source

Dissecting Bone Marrow Fibrosis in Philadelphia‐Negative Myeloproliferative Neoplasms: Multiple Roads Lead to Rome

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Philadelphia‐negative myeloproliferative neoplasms (MPN), a spectrum of blood malignancies characterized by uncontrolled myeloid proliferation, persist as a key challenge in onco‐hematology due to their intricate molecular background, heterogeneous clinical phenotypes, and variable prognoses.
Mariagiovanna Ballato, Vincenzo Fiorentino, Gabriele Ricciardi, Pietro Tralongo, Emanuela Germanà, Alessandro Allegra, Fabio Stagno, Guido Fadda, Maurizio Martini   +8 more
wiley   +1 more source

Corrigendum to: Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. [PDF]

Neuro Oncol
europepmc   +1 more source

Synchronous Multicentric WHO grade 3 Oligodendroglioma and WHO grade 3 Astrocytoma : A Case Report and Literature Review. [PDF]

J Korean Neurosurg Soc
Cho BR, Lee YS, Chung DS, Yoon WS.
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Radiomics Outperforms Conventional Tumor Volume in Prognostic Stratification Across Independent Glioma Cohorts. [PDF]

Cureus
Hashim U, Jalal A, Jabali AN, Rana H.
europepmc   +1 more source

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Alcohol metabolism induces structural instability of iron‐sulfur clusters through ROS‐mediated oxidative damage and direct covalent modification of acetaldehyde. The iron‐sulfur cluster deficiency drives metabolic reprogramming by inactivating aconitase, accumulating succinate, and impairing tRNA thiolation, thereby promoting hepatic steatosis ...
Li Xu, Zhenyang Xu, Chenli Su, Yanqian Zhao, Linjing Qiang, Xiayong Jing, Yuxiang Sun   +6 more
wiley   +1 more source