Results 221 to 230 of about 57,189 (285)

AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ‐Secretase Assembly

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
AHA1 regulates Aβ production through dual mechanisms. AHA1 promotes APP abundance through mechanisms that are at least partially independent of Hsp90 interaction, while cooperating with Hsp90 to regulate APH1/NCT pre‐complex formation, γ‐secretase assembly, and γ‐secretase activity. These coordinated mechanisms contribute to increased Aβ generation and
Arshad Ali Noorani, Sadequl Islam, Emma Filip, Kevin Catalfano, Shravan Paswan, Vaishnavi Nagarajan, Heather M. Wilkins, Brian S. J. Blagg, Kun Zou, Michael S. Wolfe   +9 more
wiley   +1 more source

Construction and external validation of a prognostic model for high-grade glioma based on IDH1 mutation status: implications for concurrent chemoradiotherapy efficacy. [PDF]

Am J Cancer Res
Lu P, Guo R, Zhao G.
europepmc   +1 more source

c-Fos-driven metabolic switch of α-ketoglutarate orchestrates progression in prostate cancer. [PDF]

Cell Death Dis
Ao L, Chen Z, Zhang J, Wang Q, Luo J, Li Z, Jiao Q, Ning B, Peng S, Hu W, Jia Y, Ci W, Wang B, Dong Z, Zhang X, Niu S.   +15 more
europepmc   +1 more source

Integrative simulation analysis of myocardial ischaemia–reperfusion injury

The Journal of Physiology, Volume 604, Issue 18, Page 7640-7662, 15 September 2026.
Abstract figure legend A comprehensive mathematical model of ventricular myocyte was developed to gain insights into the mechanisms underlying cardiac ischaemia–reperfusion injury. The model integrates excitation–contraction (E–C) coupling, cytosolic and mitochondrial pH regulation, pH dependence of major E–C coupling components and cellular energy ...
Takao Shimayoshi, Ayako Takeuchi, Satoshi Matsuoka   +2 more
wiley   +1 more source

IDH2 deficiency enhances ferroptosis-induced vascular inflammation and remodeling in diabetes. [PDF]

Sci Rep
Vu GH, Piao S, Kim M, Jeon S, Jeon BH, Kim CS.   +5 more
europepmc   +1 more source

Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern, Traver J. Wright, Erik D. Marchant, Sean P. Kilroe, William J. Durham, E. Lichar Dillon, Marc M. Baum, Michael P. Kinsky, William K. Russell, Christopher S. Fry, Pratik Gongloor, Richard B. Pyles, Randall J. Urban, Blake B. Rasmussen, Melinda Sheffield‐Moore   +14 more
wiley   +1 more source

An Expanded T2-FLAIR Mismatch Phenotype in IDH-Mutant Astrocytomas. [PDF]

J Magn Reson Imaging
Hua T, Zhang X, Li J, Jin Y, Qiu J, Liu Y, Cheng D, Duan Y, Liu X, Zhuo Z, Lin S, Liu Y.   +11 more
europepmc   +1 more source

Recent advances in the treatment of FLT3-mutated acute myeloid leukemia. [PDF]

Blood Res
Koh JS, Song IC.
europepmc   +1 more source

Radiomics meets pathology: Building the bridge for precision oncology. [PDF]

Cytojournal
Patanè V, Brunese MC, Marinelli L, Martinelli E, Nardone V, Franco R, Cappabianca S, Reginelli A.   +7 more
europepmc   +1 more source

Isocitrate dehydrogenase of soybeans.

Indian journal of biochemistry & biophysics, 1975
R C, Gupta, R, Narayan
openaire   +1 more source