Results 11 to 20 of about 1,401 (50)
Scientific Reports, 2021 A unicellular cyanobacterium Synechocystis sp. PCC 6803 possesses a unique tricarboxylic acid (TCA) cycle, wherein the intracellular citrate levels are approximately 1.5–10 times higher than the levels of other TCA cycle metabolite.
Maki Nishii +3 more
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The relative isoform expression levels of isocitrate dehydrogenase in breast cancer: IDH2 is a potential target in MDA-MB-231 cells [PDF]
Korean Journal of Clinical Oncology, 2023 Purpose The isocitrate dehydrogenase (IDH) family plays an essential role in metabolism and energy production. The relative expression levels of IDH isoforms (IDH1, IDH2, and IDH3) have prognostic significance in several malignancies, including breast ...
Shuyu Piao +7 more
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Physiological Reports, 2020 The liver regenerates NADPH via multiple pathways to maintain redox balance and reductive biosynthesis. The pentose phosphate pathway (PPP) contributes to hepatic lipogenesis by supplying NADPH, and it is thought to play a major role in response to ...
Eunsook S. Jin +2 more
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Clofibrate elevates enzyme activities of the tricarboxylic acid cycle in rat liver.
Journal of Lipid Research, 1993 Activities of the tricarboxylic acid cycle enzymes were measured in subcellular fractions of liver from rats that had been fed clofibrate for 3 weeks. Large changes in these activities per gram tissue were found in the large particle fraction, which also
C Prager +6 more
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Glioblastoma with extracranial parotid, lymph node, and pulmonary metastases: a case report
Radiology Case Reports, 2019 We present a rare case of an isocitrate dehydrogenase-wildtype glioblastoma with histologically proven parotid, cervical lymph node, and lung metastases.
Jeroen Swinnen, MD +4 more
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Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy
Xiehe Yixue Zazhi, 2023 Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism. When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the tumor
LIN Meijia +3 more
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Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). [PDF]
PLoS Genetics, 2017 DJ-1 is one of the causative genes for early onset familiar Parkinson's disease (PD) and is also considered to influence the pathogenesis of sporadic PD. DJ-1 has various physiological functions which converge on controlling intracellular reactive oxygen
Jinsung Yang +11 more
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The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. [PDF]
PLoS ONE, 2007 The tricarboxylic acid (TCA) cycle is an essential metabolic network in all oxidative organisms and provides precursors for anabolic processes and reducing factors (NADH and FADH(2)) that drive the generation of energy.
Ryan J Mailloux +6 more
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Microorganisms, 2021 Despite several discoveries in recent years, the physiology of acidophilic Micrarchaeota, such as “Candidatus Micrarchaeum harzensis A_DKE”, remains largely enigmatic, as they highly express numerous genes encoding hypothetical proteins. Due to a lacking
Dennis Winkler +2 more
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Indian Journal of Neurosurgery, 2023 Introduction In consonance with current the World Health Organization (WHO) classification of the central nervous system (CNS) tumors (2016), histological diagnosis of gliomas should be reinforced by molecular information.
Santosh Sharma +5 more
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