Results 11 to 20 of about 347,846 (181)

A real-world study of adverse drug reactions of two isocitrate dehydrogenase inhibitor based on the US FDA adverse event reporting system and VigiAccess databases [PDF]

Frontiers in Pharmacology
Background and objectivesIsocitrate dehydrogenase (IDH) inhibitor drugs (Enasidenib, Ivosidenib) restore normal metabolism and epigenetic regulation in cells, offering a precision-targeted therapeutic option for acute myeloid leukemia (AML) patients with
Mengmeng Peng, Mengmeng Peng, Qian Guo, Zihan Dang, Baiquan Zhang, Manjuan Li, Manjuan Li, Zixuan Wang, Zixuan Wang, Xuemian Lu, Xuemian Lu, Jie Lin   +11 more
doaj   +2 more sources

Isocitrate Dehydrogenase Inhibitors in Glioma: From Bench to Bedside [PDF]

Pharmaceuticals
Isocitrate dehydrogenase (IDH) mutant gliomas are a primary malignancy of the central nervous system (CNS) malignancies, most commonly affecting adults under the age of 55.
Merve Hazal Ser, Mason Webb, Anna Thomsen, Ugur Sener   +3 more
doaj   +2 more sources

IDH1(R132H) Immunoexpression in Glioma

Advanced Medical Journal, 2023
Background and objectives: Gliomas are the most common type of primary brain tumors. They result from accumu-- lation of multiple genetic alterations. Isocitrate dehydrogenase 1 mutations are detected in gliomas.
Nyan Saeed Omer, Jalal Ali Jalal , Ava Tahir Ismael   +2 more
doaj   +1 more source

Ivosidenib in Isocitrate Dehydrogenase 1–Mutated Advanced Glioma

Journal of Clinical Oncology, 2020
PURPOSE Diffuse gliomas are malignant brain tumors that include lower-grade gliomas (LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor grade is typically associated with contrast enhancement on magnetic resonance imaging ...
I. Mellinghoff, B. Ellingson, M. Touat, E. Maher, M. I. de la Fuente, M. Holdhoff, G. Cote, H. Burris, F. Janku, R. Young, Raymond Y Huang, Liewen Jiang, S. Choe, Bin Fan, K. Yen, Min Lu, C. Bowden, L. Steelman, S. Pandya, T. Cloughesy, P. Wen   +20 more
semanticscholar   +1 more source

Isocitrate dehydrogenase (IDH) status prediction in histopathology images of gliomas using deep learning

Scientific Reports, 2020
Mutations in isocitrate dehydrogenase genes IDH1 and IDH2 are frequently found in diffuse and anaplastic astrocytic and oligodendroglial tumours as well as in secondary glioblastomas.
Sidong Liu, Zubair Shah, A. Sav, C. Russo, S. Berkovsky, Y. Qian, E. Coiera, A. Di Ieva   +7 more
semanticscholar   +1 more source

Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in Combination With Azacitidine for Newly Diagnosed Acute Myeloid Leukemia

Journal of Clinical Oncology, 2020
PURPOSE Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of IDH1-mutant (mIDH1) acute myeloid leukemia (AML).
C. Dinardo, A. Stein, E. Stein, A. Fathi, O. Frankfurt, A. Schuh, H. Döhner, G. Martinelli, P. Patel, E. Raffoux, P. Tan, A. Zeidan, S. de Botton, H. Kantarjian, R. Stone, M. Frattini, F. Lersch, J. Gong, D. Gianolio, V. Zhang, A. Franovic, Bin Fan, M. Goldwasser, S. Daigle, S. Choe, Bin Wu, T. Winkler, P. Vyas   +27 more
semanticscholar   +1 more source

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications

Biomedicines, 2020
Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which impacts ...
Yang Liu, F. Lang, F. Chou, K. Zaghloul, Chunzhang Yang   +4 more
semanticscholar   +1 more source

Biochemical adaptation of Weigela florida «Variegata» Bunge A. D. C. microclones to salt- and copper induced stress [PDF]

Сибирский лесной журнал, 2017
Microclones of perennial shrub Weigela florida «Variegata» were prepared, adapted to the conditions of salinity and increased copper ions proportion during the three-step in vitro experiment.
O. A. Zemlyanukhina, V. N. Kalaev, V. S. Voronina, A. T. Eprintsev   +3 more
doaj   +1 more source

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. [PDF]

PLoS ONE, 2011
Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2
Genglin Jin, Zachary J Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D Bigner, Hai Yan   +7 more
doaj   +1 more source

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu, Yang Gu, Yang Gu, Yijing Yan, Jingbo Ma, Jingbo Ma, Xiaoman Sun, Peng Xu, Peng Xu, Peng Xu   +9 more
doaj   +1 more source