Results 31 to 40 of about 43,490 (164)
Medicina U.P.B., 2023 El perfil molecular de los gliomas permite garantizar la precisión del diagnóstico, informar el pronóstico e identificar opciones de tratamiento.
León Darío Ortiz +4 more
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Impact of IDH Mutations on DNA Methylation of Acute Myeloid Leukemia Related Genes: A Review Article
مجلة كلية الطبBackground: Acute myeloid leukemia is one of the deadliest hematologic malignancies that is marked by genetic alterations, abnormal cellular functions, and proliferation. Mutations in isocitrate dehydrogenase genes, particularly isocitrate dehydrogenase
Duha M. Bayram +2 more
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Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
Biomarker Research, 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid (TCA) cycle. IDH mutation produces a neomorphic enzyme, which can lead to the abnormal accumulation of R-2-HG and ...
Xiaoyan Liu, Yuping Gong
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Frontiers in OncologyIntroductionGliomas are infiltrative primary intracranial tumors with marked biological and clinical heterogeneity. Prognosis varies widely and depends on tumor grade, histopathological characteristics, and molecular alterations. Isocitrate dehydrogenase
Esra Sümer-Arpak +12 more
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Current Issues in Molecular Biology, 2022 Both IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrogenase 2) mutations play a vital role in the development of gliomas through disruption of normal cellular metabolic processes.
Alexander Yuile +9 more
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The equilibrium constant of the isocitrate dehydrogenase reaction [PDF]
Biochemical Journal, 1968 1. The equilibrium constant for oxidative decarboxylation of isocitrate by NADP+, catalysed by isocitrate dehydrogenase, was measured in solutions of various ionic strengths and at several temperatures. 2. Thermodynamic values for the reaction were obtained by extrapolation to zero ionic strength, and the heat of reaction was estimated. 3.
J C, Londesborough, K, Dalziel
openaire +2 more sources
Adjunctive perampanel for glioma-associated epilepsy
Epilepsy and Behavior Case Reports, 2018 Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy.
Anastasie M. Dunn-Pirio +9 more
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Mutasi Isocitrate Dehydrogenase 1 dan 2 pada Glioma
JBN (Jurnal Bedah Nasional), 2020 Klasifikasi tumor sistem saraf pusat WHO terakhir didasarkan atas histogenesis tumor dan karakteristik molekuler genetik. Perubahan klasifikasi yang paling signifikan terjadi pada tumor glioma difus yang paling signifikan, yaitu katagori tumor secara ...
Ni Putu Sriwidyani
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Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients
Medeniyet Medical Journal, 2023 Objective: Neuroblastoma is one of the common tumors of childhood. The demonstration of new factors such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations will be important in the diagnosis and treatment.
Emre LEVENTOGLU +11 more
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Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
The Scientific World Journal, 2014 Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε ...
Martin Krátký +6 more
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