Results 11 to 20 of about 403,859 (288)
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
Cell Reports Medicine, 2021 Summary The most frequently mutated metabolic genes in human cancer are those encoding the enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been identified in more than 20 tumor types.
Ingvild Hvinden +3 more
semanticscholar +3 more sources
Cancers, 2022 Simple Summary While isocitrate dehydrogenases have been known for decades, their mechanisms in tumors are gradually becoming clearer. The three isocitrate dehydrogenase isoforms in human cells differ in their subcellular localization, molecular ...
Q. He +3 more
semanticscholar +3 more sources
Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas. [PDF]
PLoS ONE, 2015 Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas.
Ming-Yang Li +8 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2022 Background and Purpose: To quantitatively compare the recurrence patterns of glioblastoma (isocitrate dehydrogenase-wild type) versus grade 4 isocitrate dehydrogenase-mutant astrocytoma (wild type isocitrate dehydrogenase and mutant isocitrate ...
James Stewart PhD +18 more
doaj +1 more source
Physiological regulation of isocitrate dehydrogenase and the role of 2-oxoglutarate in Prochlorococcus sp. strain PCC 9511. [PDF]
PLoS ONE, 2014 The enzyme isocitrate dehydrogenase (ICDH; EC 1.1.1.42) catalyzes the oxidative decarboxylation of isocitrate, to produce 2-oxoglutarate. The incompleteness of the tricarboxylic acids cycle in marine cyanobacteria confers a special importance to ...
María Agustina Domínguez-Martín +5 more
doaj +1 more source
Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma
Oncogene, 2021 Brain tumors actively reprogram their cellular metabolism to survive and proliferate, thus offering potential therapeutic opportunities. Over the past decade, extensive research has been done on mutant IDH enzymes as markers of good prognosis in ...
Gabriel Alzial +5 more
semanticscholar +1 more source
Nanomaterials, 2022 Two three-dimensional (3D) stochastic microsensors based on immobilization of protoporphyrin IX (PIX) in single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT) decorated with copper (Cu) and gold (Au) nanoparticles were designed
Raluca-Ioana Stefan-van Staden +3 more
doaj +1 more source
IDH1(R132H) Immunoexpression in Glioma
Advanced Medical Journal, 2023 Background and objectives: Gliomas are the most common type of primary brain tumors. They result from accumu-- lation of multiple genetic alterations. Isocitrate dehydrogenase 1 mutations are detected in gliomas.
Nyan Saeed Omer +2 more
doaj +1 more source
Ivosidenib in Isocitrate Dehydrogenase 1–Mutated Advanced Glioma
Journal of Clinical Oncology, 2020 PURPOSE Diffuse gliomas are malignant brain tumors that include lower-grade gliomas (LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor grade is typically associated with contrast enhancement on magnetic resonance imaging ...
I. Mellinghoff +20 more
semanticscholar +1 more source
Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas
Neuro-Oncology, 2017 Biqi Zhang +9 more
semanticscholar +3 more sources