Results 11 to 20 of about 190,806 (273)
Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots
Biologia Plantarum, 2012 NADP-dependent isocitrate dehydrogenase (NADP-ICDH) catalyses the production of NADPH, which is an essential component in the cellular homeostasis. In Arabidopsis, the kinetic parameters (K m and V max) of cytosolic NADP-ICDH were different in leaves and
M. Leterrier +3 more
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Studying the Phosphorylation of Isocitrate Dehydrogenase in Humans [PDF]
, 2023 Isocitrate dehydrogenase is an important enzyme in the citric acid cycle where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate.
Smith, Hannah
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Studies of Isocitrate Dehydrogenase From Bacillus caldotenax [PDF]
, 1992 Most micro-organisms contain an NADP-dependent isocitrate dehydrogenase (ICDH) activity. During growth of micro-organisms on acetate as the sole carbon source the two enzymes of the glyoxylate bypass, isocitrate lyase (ICL) and malate synthase (MS), are ...
Wild, Catherine Margaret
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Isocitrate dehydrogenase mutations in gliomas [PDF]
Neuro-Oncology, 2015 Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) were identified in the vast majority of progressive gliomas and secondary glioblastomas (GBMs).
Matthew S, Waitkus +2 more
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Isocitrate dehydrogenase mutations in leukemia [PDF]
Journal of Clinical Investigation, 2013 Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the
Anna Sophia, McKenney, Ross L, Levine
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Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu +9 more
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Isocitrate Dehydrogenase Genes [PDF]
Deutsches Ärzteblatt international, 2015 The molecular classification and taxonomy of malignant diseases, such as the one successfully applied and published by The Cancer Genome Atlas Project TCGA (http://cancergenome.nih.gov/) for urinary bladder and colorectal cancer, adenocarcinoma of the stomach, and glioblastoma multiforme, provides the opportunity to define so-called driver mutations ...
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Scientific Reports, 2021 A unicellular cyanobacterium Synechocystis sp. PCC 6803 possesses a unique tricarboxylic acid (TCA) cycle, wherein the intracellular citrate levels are approximately 1.5–10 times higher than the levels of other TCA cycle metabolite.
Maki Nishii +3 more
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Nondecarboxylating and Decarboxylating Isocitrate Dehydrogenases: Oxalosuccinate Reductase as an Ancestral Form of Isocitrate Dehydrogenase [PDF]
Journal of Bacteriology, 2008 ABSTRACTIsocitrate dehydrogenase (ICDH) fromHydrogenobacter thermophiluscatalyzes the reduction of oxalosuccinate, which corresponds to the second step of the reductive carboxylation of 2-oxoglutarate in the reductive tricarboxylic acid cycle. In this study, the oxidation reaction catalyzed byH. thermophilusICDH was kinetically analyzed. As a result, a
Miho, Aoshima, Yasuo, Igarashi
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Animal, 2022 The enzyme isocitrate dehydrogenase (EC 1.1.1.42; 1; NADP+ dependent) located in the mammary cell cytosol mediates the synthesis of the majority of reducing equivalents for the energetically demanding milk fat and cholesterol synthesis in mammary cell ...
T. Larsen +3 more
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