Isocitrate dehydrogenase mutations in leukemia [PDF]
Journal of Clinical Investigation, 2013 Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the
Anna Sophia, McKenney, Ross L, Levine
openaire +2 more sources
Experimental and Molecular Medicine, 2020 Isocitrate dehydrogenase 2 (IDH2) is an NADP+-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of ...
Jae-Ho Lee +16 more
semanticscholar +1 more source
Clofibrate elevates enzyme activities of the tricarboxylic acid cycle in rat liver.
Journal of Lipid Research, 1993 Activities of the tricarboxylic acid cycle enzymes were measured in subcellular fractions of liver from rats that had been fed clofibrate for 3 weeks. Large changes in these activities per gram tissue were found in the large particle fraction, which also
C Prager +6 more
doaj +1 more source
Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. [PDF]
, 2011 Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits.
Blumwald, Eduardo +8 more
core +3 more sources
Glioblastoma with extracranial parotid, lymph node, and pulmonary metastases: a case report
Radiology Case Reports, 2019 We present a rare case of an isocitrate dehydrogenase-wildtype glioblastoma with histologically proven parotid, cervical lymph node, and lung metastases.
Jeroen Swinnen, MD +4 more
doaj +1 more source
A histochemical study of the red and white muscle fibers Part III. Activity of the diphosphopyridine nucleotide diaphorase and triphosphopyridine nucleotide diaphorase in muscle fibers [PDF]
, 1958 From the histochemical study of DPN and TPN diaphorase on the striated muscles of the cats, the following results were obtained. 1. M. gastrocnemius, which belongs to the white muscle by naked eye, consists of three types of muscle fibers distinguished ...
Ogata, Takuro
core +1 more source
Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. [PDF]
, 2017 Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and ...
Berger, Mitchel S +12 more
core +1 more source
Journal of Gastrointestinal Oncology, 2019 Background The recognition of distinct molecular subgroups within cholangiocarcinoma (CC), along with the increasing availability of targeted therapies, suggests that further characterization of the prevalence and prognosis of frequently occurring ...
A. Boscoe, C. Rolland, R. Kelley
semanticscholar +1 more source
Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics Development
Frontiers in Oncology, 2019 Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. In recent years, it has been found that IDH mutations are closely related to the occurrence and development of glioma, and ...
Juan Huang +5 more
semanticscholar +1 more source
The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. [PDF]
PLoS ONE, 2007 The tricarboxylic acid (TCA) cycle is an essential metabolic network in all oxidative organisms and provides precursors for anabolic processes and reducing factors (NADH and FADH(2)) that drive the generation of energy.
Ryan J Mailloux +6 more
doaj +1 more source