Results 51 to 60 of about 190,806 (273)

Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients

Medeniyet Medical Journal, 2023
Objective: Neuroblastoma is one of the common tumors of childhood. The demonstration of new factors such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations will be important in the diagnosis and treatment.
Emre LEVENTOGLU, Gurses SAHIN, Sule YESIL, Ceyhun BOZKURT, Nazmiye YUKSEK, Ali FETTAH, Sule TOPRAK, Burcak KURUCU BILGIN, Emre CAPKINOGLU, Nilgun EROGLU, Sibel AKPINAR TEKGUNDUZ, Ayse Ulya ERTEM   +11 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

The Scientific World Journal, 2014
Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε ...
Martin Krátký, Eva Novotná, Shalini Saxena, Perumal Yogeeswari, Dharmarajan Sriram, Markéta Švarcová, Jarmila Vinšová   +6 more
doaj   +1 more source

CLINICAL STUDIES ON ISOCITRIC DEHYDROGENASE

Nihon Naika Gakkai Zasshi, 1963
イソクエン酸脱水素酵素(ICD)はTPNを補酵素とする脱水素酵素であり肝細胞中の糸粒体に主として認められているが,著者は正常者および各種疾患々者血清中の本酵素活性値を測定した.またこれと並行してトランスアミナーゼ活性値,乳酸脱水素酵素活性値を測定し,各酵素の変動および相関につき觀察した.イソクエン酸脱水素酵素は他の酵素に比べ,肝疾患に特異的であり,特に急性肝炎黄疸前期に著明な活性値上昇を来たし,また肝性昏睡時に中等度の活性値の上昇を来たすことを認めた.慢性肝炎,肝硬変では正常乃至は正常値を多少上廻る活性値を示したが,閉塞性黄疸では一般に上昇は認められず,二次的に肝細胞障害を来たした例には活性値上昇が認められた.その他の疾患ではICD値は正常値を示した ...
openaire   +3 more sources

Cancer-Associated Isocitrate Dehydrogenase Mutations [PDF]

The Oncologist, 2012
The role of isocitrate dehydrogenase mutations as a therapeutic target for cancer therapy is examined.
Katharine E, Yen, David P, Schenkein
openaire   +2 more sources

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Isocitrate Dehydrogenase (IDH) Mutations in Hematological Malignancies: Epidemiology, Mechanisms, and Therapeutic Strategies

MedComm – Future Medicine
Isocitrate dehydrogenase (IDH) mutation is an important molecular abnormality in hematological malignancies, occurring widely in various disease types such as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome (
Jinkun Xu, Haiying Bai, Lijuan Hu
doaj   +1 more source

Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods [PDF]

, 2020
Altered cellular metabolism, as a result of oncogenic mutations, has been observed in a range of cancer types. A detailed understanding of how cancers modify cellular metabolism, which includes changes to the genome, proteome and metabolome, is therefore
Walsby-Tickle, John
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source