Results 61 to 70 of about 403,859 (288)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Frontiers in Endocrinology, 2020
Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangiocarcinomas.
Li Su, Xinglong Zhang, Lei Zheng, Miaomiao Wang, Zhifa Zhu, Ping Li   +5 more
doaj   +1 more source

Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients

Medeniyet Medical Journal, 2023
Objective: Neuroblastoma is one of the common tumors of childhood. The demonstration of new factors such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations will be important in the diagnosis and treatment.
Emre LEVENTOGLU, Gurses SAHIN, Sule YESIL, Ceyhun BOZKURT, Nazmiye YUKSEK, Ali FETTAH, Sule TOPRAK, Burcak KURUCU BILGIN, Emre CAPKINOGLU, Nilgun EROGLU, Sibel AKPINAR TEKGUNDUZ, Ayse Ulya ERTEM   +11 more
doaj   +1 more source

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

bioRxiv, 2018
Somatic mutations in cytosolic or mitochondrial isoforms of isocitrate dehydrogenase (IDH1 or IDH2, respectively) contribute to oncogenesis via production of the metabolite 2-hydroxyglutarate (2HG).
James J. Harding, M. Lowery, A. Shih, J. Schvartzman, Shengqi Hou, C. Famulare, Minal A. Patel, M. Roshal, Richard Do, A. Zehir, Daoqi You, S. D. Selcuklu, A. Viale, Marty S Tallman, D. Hyman, Ed Reznik, Lydia W. S. Finley, E. Papaemmanuil, A. Tosolini, M. Frattini, Kyle J. MacBeth, Guowen Liu, Bin Fan, S. Choe, Bin Wu, Y. Janjigian, I. Mellinghoff, L. A. Díaz, Ross L Levine, G. Abou-Alfa, E. Stein, A. Intlekofer   +31 more
semanticscholar   +1 more source

Radiomics-based models to predict IDH mutation status and prognosis in gliomas using MRI: a multicenter study

Frontiers in Oncology
IntroductionGliomas are infiltrative primary intracranial tumors with marked biological and clinical heterogeneity. Prognosis varies widely and depends on tumor grade, histopathological characteristics, and molecular alterations. Isocitrate dehydrogenase
Esra Sümer-Arpak, Esra Sümer-Arpak, Ayca Ersen Danyeli, Ayca Ersen Danyeli, M. Cengiz Yakicier, M. Necmettin Pamir, M. Necmettin Pamir, Koray Özduman, Koray Özduman, Alp Dinçer, Alp Dinçer, Esin Ozturk-Isik, Esin Ozturk-Isik   +12 more
doaj   +1 more source

Adjunctive perampanel for glioma-associated epilepsy

Epilepsy and Behavior Case Reports, 2018
Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy.
Anastasie M. Dunn-Pirio, Sarah Woodring, Eric Lipp, James E. Herndon, II, Patrick Healy, Mallika Weant, Dina Randazzo, Annick Desjardins, Henry S. Friedman, Katherine B. Peters   +9 more
doaj   +1 more source

Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review

Current Issues in Molecular Biology, 2022
Both IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrogenase 2) mutations play a vital role in the development of gliomas through disruption of normal cellular metabolic processes.
Alexander Yuile, Laveniya Satgunaseelan, Joe Wei, Marina Kastelan, Michael F. Back, Maggie Lee, Heng Wei, Michael E. Buckland, Adrian Lee, Helen R. Wheeler   +9 more
doaj   +1 more source

Pay32p of the Yeast Yarrowia lipolytica Is an Intraperoxisomal Component of the Matrix Protein Translocation Machinery [PDF]

, 1995
Pay mutants of the yeast Yarrowia lipolytica fail to assemble functional peroxisomes. One mutant strain, pay32-1, has abnormally small peroxisomes that are often found in clusters surrounded by membranous material.
Rachubinski, Richard A.,, Szilard, Rachel K.,, Titorenko, Vladimir I.,, Veenhuis, Marten,   +3 more
core   +3 more sources

Mitochondrial Isocitrate Dehydrogenases from Yeast

Journal of Biological Chemistry, 1966
Abstract A polarographic technique suitable for kinetic studies of either isolated or bound pyridine nucleotide-linked dehydrogenases was used to investigate the isocitrate dehydrogenases of yeast mitochondria. Intact mitochondria were found to contain both triphosphopyridine nucleotide- and diphosphopyridine nucleotide-linked isocitrate dehydrogenases
C, Bernofsky, M F, Utter
openaire   +2 more sources

Differentiation Syndrome Associated With Enasidenib, a Selective Inhibitor of Mutant Isocitrate Dehydrogenase 2: Analysis of a Phase 1/2 Study

JAMA Oncology, 2018
Importance Enasidenib mesylate, a mutant isocitrate dehydrogenase 2 (IDH2) protein inhibitor that promotes differentiation of leukemic myeloblasts, was recently approved by the US Food and Drug Administration for use in relapsed/refractory (R/R) mutant ...
A. Fathi, C. Dinardo, I. Kline, Laurie Kenvin, I. Gupta, E. Attar, E. Stein, S. de Botton   +7 more
semanticscholar   +1 more source