Results 81 to 90 of about 403,859 (288)

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Enasidenib in the treatment of relapsed/refractory acute myeloid leukemia: an evidence-based review of its place in therapy. [PDF]

, 2019
Introduction: Acute myeloid leukemia (AML) remains a disease with high mortality, especially for older patients and those with relapsed/refractory (R/R) disease.
Galkin, Maria, Jonas, Brian A
core   +1 more source

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence [PDF]

, 2016
Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology ...
A Brand, A Enache-Angoulvant, A Rodaki, A Rosenbach, AJP Brown, AJP Brown, AL Diaz-Perez, Alistair J. P. Brown, AM New, B Gorke, C Fradin, C Janke, C Taxis, CJ Barelle, CR Rocha, D Lohr, D Sandai, DA Opulente, David Stead, Delma S. Childers, DH Owen, DM MacCallum, Donna M. MacCallum, DS Childers, EJ Munoz-Elias, Elizabeth R. Ballou, F Cao, F Sherman, FC Odds, Gabriela Mol Avelar, H Holzer, H Zhou, HG Crabtree, HL Cheah, Ingrida Raziunaite, IV Ene, IV Ene, J Piskur, J Regelmann, J Shen, JA Sexton, JH Hegemann, JK Byron, JM Gancedo, Joanna Mackie, JP Barford, K Piekarska, K Ueno, M Carlson, M Hammerle, M Johnston, M Niimi, MA Navas, MA Ramirez, MC Lorenz, MC Lorenz, Megan D. Lenardon, MS Price, Neil A. R. Gow, O Santt, P Miramon, P Radivojac, PL Fidel Jr., R Menssen, R Sabouraud, R Sharma, RA Calderone, RA Calderone, Robert A. Cramer, S Funayama, Susan Budge, T Inada, T Schule, TH Rude, YS Lopez-Boado, Z Yin   +75 more
core   +4 more sources

Metabolome-guided genomics to identify mutations in isocitrate dehydrogenase, fumarate hydratase and succinate dehydrogenase genes in pheochromocytoma and paraganglioma

Genetics in Medicine, 2018
Metabolic aberrations have been described in neoplasms with pathogenic variants (PV) in the Krebs cycle genes encoding succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH).
S. Richter, L. Gieldon, Ying Pang, M. Peitzsch, Thanh T. Huynh, R. Letón, Bruna Viana, T. Ercolino, Anastasios Mangelis, E. Rapizzi, M. Menschikowski, D. Aust, M. Kroiss, F. Beuschlein, V. Gudziol, H. Timmers, J. Lenders, M. Mannelli, A. Cascón, K. Pacak, M. Robledo, G. Eisenhofer, B. Klink   +22 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Electron transport phosphorylation in rumen butyrivibrios: unprecedented ATP yield for glucose fermentation to butyrate. [PDF]

, 2015
From a genomic analysis of rumen butyrivibrios (Butyrivibrio and Pseudobutyrivibrio sp.), we have re-evaluated the contribution of electron transport phosphorylation (ETP) to ATP formation in this group.
Firkins, Jeffrey L, Hackmann, Timothy J
core   +2 more sources

Characterizing Lysine Acetylation of Isocitrate Dehydrogenase in Escherichia coli.

Journal of Molecular Biology, 2018
The Escherichia coli isocitrate dehydrogenase (ICDH) is one of the tricarboxylic acid cycle enzymes, playing key roles in energy production and carbon flux regulation. E.
Suryawanshi Venkat Shivaji, Hao Chen, Alleigh Stahman, D. Hudson, P. McGuire, Qinglei Gan, Chenguang Fan   +6 more
semanticscholar   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Expression of multidrug transporter P‐glycoprotein in Pichia pastoris affects the host's methanol metabolism

Microbial Biotechnology, 2019
Summary Pichia pastoris KM71H (MutS) is an efficient producer of hard‐to‐express proteins such as the membrane protein P‐glycoprotein (Pgp), an ATP‐powered efflux pump which is expressed properly, but at very low concentration, using the conventional ...
Wan‐cang Liu, Fei Zhou, Di Xia, Joseph Shiloach   +3 more
doaj   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source