Results 71 to 80 of about 403,859 (288)

Mutasi Isocitrate Dehydrogenase 1 dan 2 pada Glioma

JBN (Jurnal Bedah Nasional), 2020
Klasifikasi tumor sistem saraf pusat WHO terakhir didasarkan atas histogenesis tumor dan karakteristik molekuler genetik. Perubahan klasifikasi yang paling signifikan terjadi pada tumor glioma difus yang paling signifikan, yaitu katagori tumor secara ...
Ni Putu Sriwidyani
doaj   +1 more source

Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applications. [PDF]

, 2005
Background: Diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. Clinical, epidemiological, and experimental data indicate that pancreatic cancer causes diabetes mellitus by releasing soluble mediators which interfere ...
BALDO G, BASSO D, FLAGIELLO A, FOGAR P, GIUNCO S, GRECO E, NAVAGLIA F, PEDRAZZOLI S, PLEBANI M., PUCCI, PIETRO, VALERIO A, ZAMBON CF   +11 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

The Scientific World Journal, 2014
Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε ...
Martin Krátký, Eva Novotná, Shalini Saxena, Perumal Yogeeswari, Dharmarajan Sriram, Markéta Švarcová, Jarmila Vinšová   +6 more
doaj   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications [PDF]

MedComm (2020)
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Fang Y, Wang X, Luo K, Dakal T, Bai H, Xu C, Zhang G.   +6 more
europepmc   +2 more sources

An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival. [PDF]

, 2019
BackgroundIn 2016, the World Health Organization reclassified the definition of glioblastoma (GBM), dividing these tumors into isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant GBM, where the vast majority of GBMs are IDH-wild-type.
Barnholtz-Sloan, Jill S, Berger, Mitchel S, Chunduru, Pranathi, Cioffi, Gino, Gittleman, Haley, Molinaro, Annette M, Sloan, Andrew E   +6 more
core   +1 more source

Mild reductions in cytosolic NADP-dependent isocitrate dehydrogenase activity result in lower amino acid contents and pigmentation without impacting growth [PDF]

, 2010
Transgenic tomato (Solanum lycopersicum) plants were generated targeting the cytosolic NADP-dependent isocitrate dehydrogenase gene (SlICDH1) via the RNA interference approach.
Ronan Sulpice, Agata Sienkiewicz-Porzucek, Sonia Osorio, Ina Krahnert, Mark Stitt, Alisdair R. Fernie, Adriano Nunes-Nesi, WL Araújo, S Aubert, CG Bartoli, L Bender-Machado, O Bläsing, R Boldt, F Carrari, R Chen, RD Chen, DW Chia, FJ Corpas, T Czechowski, CG Oliveira Dal’Molin de, C Dutilleul, C Dutilleul, AR Fernie, AR Fernie, S Ferrario-Mery, S Fieuw, C Fritz, F Gallardo, S Gálvez, S Gálvez, S Gálvez, S Gálvez, N Gaude, PPG Gauthier, Y Gibon, Y Gibon, M Hodges, M Hodges, J Huege, AU Igamberdiev, AU Igamberdiev, T Isaacson, M Karimi, J Kopka, A Kruse, M Lancien, V Landschütze, T Lemaitre, XJ Liu, A Nunes-Nesi, A Nunes-Nesi, J Palomo, MG Poolman, AS Raghavendra, SA Robinson, U Roessner, U Roessner-Tunali, S Schaarschmidt, N Schauer, R Scheibe, R Scheibe, WR Scheible, WR Scheible, J Schneidereit, JN Siedow, A Sienkiewicz-Porzucek, A Sienkiewicz-Porzucek, C Studart-Guimarães, LJ Sweetlove, E Tauberger, G Tcherkez, T Tercé-Laforgue, E Urbanczyk-Wochniak, S Wang, B Wigge, MI Zanor   +75 more
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The representation of protein complexes in the Protein Ontology [PDF]

, 2011
Representing species-specific proteins and protein complexes in ontologies that are both human and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets.
Arighi, Cecilia, Blake, Judith, Bult, Carol, Drabkin, Harold, D’Eustachio, Peter, Evsikov, Alexei, Natale, Darren, Roberts, Natalia, Ruttenberg, Alan, Smith, Barry, Wu, Cathy   +10 more
core  

The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration [PDF]

, 2019
Macrophages are crucial for tissue homeostasis. Based on their activation, they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro-inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO).
Alessio Torcinaro, Elisabetta Ferraro, Fielding RA, Francesca De Santa, Galván-Peña S, Hard GC, Huang X, Kawanishi N, Laura Vitiello, Munder M, Ménégaut L, Ohtsu A, Tidball JG, Zhang X   +13 more
core   +1 more source