Results 191 to 200 of about 68,056 (282)

Affinity cleavage at the divalent metal site of porcine NAD‐specific isocitrate dehydrogenase [PDF]

, 2000
Y C Huang, Sambanthamurthy Soundar, Roberta F. Colman   +2 more
openalex   +1 more source

Contemporary outcomes of octa‐nonagenarians with newly diagnosed acute myeloid leukemia

Cancer, Volume 131, Issue 16, 15 August 2025.
Abstract Background Octa‐nonagenarians with acute myeloid leukemia (AML) represent a high‐risk group due to frequently poor performance status, adverse genomics (e.g., TP53 mutations, complex karyotype), a high incidence of secondary AML, and inability to undergo an allogeneic stem cell transplantation.
Jayastu Senapati, Hagop M. Kantarjian, Tapan M. Kadia, Jeannot Kekedjian, Gautam Borthakur, Naval Daver, Courtney D. DiNardo, Elias Jabbour, Prithviraj Bose, Nicholas J. Short, Musa Yilmaz, Nitin Jain, Naveen Pemmaraju, Hussein A. Abbas, Ghayas C. Issa, Abhishek Maiti, Guillermo Montalban Bravo, Indraneel Deshmukh, Elizabeth Shpall, Partow Kebriaei, Uday Popat, Sanam Loghavi, Beenu Thakral, Guilin Tang, Fadi G. Haddad, Yesid Alvarado, Guillermo Garcia Manero, Farhad Ravandi   +27 more
wiley   +1 more source

Catalytically distinct metabolic enzyme isocitrate dehydrogenase 1 mutants tune phenotype severity in tumor models. [PDF]

J Biol Chem
Schwartz AV, Chao G, Robinson M, Conley BM, Ahmed Adam MA, Wells GA, Hoang A, Albekioni E, Gallo C, Weeks J, Yunker K, Quichocho G, George UZ, Niesman I, House CD, Turcan Ş, Sohl CD.   +16 more
europepmc   +1 more source

Crystallization and preliminary X-ray diffraction studies of monomeric isocitrate dehydrogenase fromCorynrbacterium glutamicum. Erratum [PDF]

, 2000
Gerald F. Audette, J. Wilson Quail, K. Hayakawa, Cheng Bai, Ridong Chen, Louis T. J. Delbaere   +5 more
openalex   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, Volume 599, Issue 16, Page 2334-2345, August 2025.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Clinical Implications of Isocitrate Dehydrogenase Mutations and Targeted Treatment of Acute Myeloid Leukemia with Mutant Isocitrate Dehydrogenase Inhibitors-Recent Advances, Challenges and Future Prospects. [PDF]

Int J Mol Sci
Kowalczyk A, Zarychta J, Lejman M, Latoch E, Zawitkowska J.   +4 more
europepmc   +1 more source

The cytochrome oxidase defect in ISC‐depleted yeast is caused by impaired iron–sulfur cluster maturation of the mitoribosome assembly factor Rsm22

FEBS Letters, Volume 599, Issue 16, Page 2301-2317, August 2025.
The yeast mitoribosome assembly factor Rsm22 contains a [4Fe‐4S] cluster that is matured by the mitochondrial iron–sulfur cluster assembly (ISC) machinery. Defects in ISC components result in impaired mitochondrial protein synthesis due to a mitoribosome assembly defect.
Ulrich Mühlenhoff, Dominik Trauth, Weronika Śliwińska, Linda Boss, Roland Lill   +4 more
wiley   +1 more source

Isocitrate Dehydrogenase 2 (IDH2)-Mutant Metastatic Esthesioneuroblastoma: A Case Report and Review of Current Therapeutic Options. [PDF]

Cureus
Banha R, Fernandes R, Floudas CS, Vieira C.   +3 more
europepmc   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, Volume 19, Issue 8, Page 2249-2269, August 2025.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Prediction of isocitrate dehydrogenase mutation status in WHO grade II glioma by diffusion kurtosis imaging. [PDF]

Pol J Radiol
Wu W, Zhang H.
europepmc   +1 more source