Results 171 to 180 of about 190,806 (273)

Tumor Treating Fields Enhance Temozolomide‐Associated Growth Suppression in Glioblastoma Cells and Patient‐Derived Organoids Through Cell‐Cycle Blockade, Apoptosis, and SMAD‐Associated Signaling

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Tumor Treating Fields enhanced temozolomide‐associated growth suppression in glioblastoma cells and patient‐derived organoids. Combined treatment reduced viability and clonogenic growth, increased apoptosis‐associated responses, and was accompanied by G2/M‐phase accumulation and selected SMAD‐associated signaling changes.
Haiping Zhu, Yingbo Hou, Xuetao Li, Yi Tang, Zuoyu Jiang, Yang Zhang, Xuewen Zhang, Jiaming Du, Yang Zhu, Hanmiao Dong, Yeyang Xu, Ruoyu Sun, Chenyang Li, Zijian Han, Jian Lu, Lingzhi Xiong, Yulun Huang   +16 more
wiley   +1 more source

Delta-like ligand 3 expression in isocitrate dehydrogenase-mutant and isocitrate dehydrogenase-wildtype glioma is largely retained at recurrence, supporting its potential as a therapeutic target. [PDF]

Neurooncol Adv
Luning R, Maas SLN, French PJ, Hoogstrate Y, van Hijfte L, Head R, de Heer I, van den Bosch TPP, Woehrer A, van den Bent MJ, Geurts M.   +10 more
europepmc   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study

Head &Neck, Volume 48, Issue 10, Page 2810-2820, October 2026.
ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange, Mathilde Morisseau, Justin Michel, Thibaut Reverdy, Sylvain Morinière, Amaury Daste, Maxime Humbert, Caroline Viala, Pauline Corbaux, Tiffany Darbas, François‐Régis Ferrand, Valentin Favier, Camille Evrard, Diane Evrard, Delphine Farneti, Sarah Betrian‐Lagarde, Victor Sarradin   +16 more
wiley   +1 more source

Noninvasive Identification of Isocitrate Dehydrogenase 1/2 Mutation in Brainstem Gliomas. [PDF]

JCO Precis Oncol
Kushnirsky M, Lin AL, Bale T, Moss NS, Rosenblum M, Sait SF, Schaff LR, Gavrilovic IT, Pentsova E, Grommes C, Meng A, Imber B, Tabar V, Yu KKH, Miller A, Malani R, Karajannis MA, Mellinghoff I, Young RJ, Thakur S.   +19 more
europepmc   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Corrigendum to: Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. [PDF]

Neuro Oncol
europepmc   +1 more source

A narrative review of mutant isocitrate dehydrogenase AML in Japan based on experience with ivosidenib in AGILE. [PDF]

Int J Hematol
Hiramatsu Y, Urata S, Ishikawa T, Yamauchi T.   +3 more
europepmc   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Predicting isocitrate dehydrogenase mutation status in acute myeloid leukemia from gene expression profiles by machine learning. [PDF]

NAR Genom Bioinform
Jung I, Vitte AL, Chuffart F, Chevalier S, Mossuz P, Khochbin S, Bourova-Flin E.   +6 more
europepmc   +1 more source