Results 151 to 160 of about 190,806 (273)

Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism. [PDF]

Acta Neuropathol
Pun M, Deogharkar A, Natarajan SK, Nuechterlein N, Tian W, Ji S, Young E, Yang F, Hawes D, Andren AC, Owen JH, Rau S, Su F, Cao X, Parolia A, Prince M, Fry J, Gardner PA, Yang R, Judkins AR, Koschmann CJ, Venteicher AS, Lyssiotis CA, Chinnaiyan AM, Venneti S.   +24 more
europepmc   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2629-2642, October 2026.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

A novel isocitrate dehydrogenase 1 G131D mutation in glioblastoma

Chinese Medical Journal, 2021
Lei-Ming Wang, Chao Song, Ying-Xue Li, Xue-Dong Zhang, Yu-Hang Ji, Wen-Juan Wen, Peng Lyu   +6 more
doaj   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2713-2728, October 2026.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Factors Associated With Perceived Cognitive Dysfunction in Patients With Primary Brain Tumors: The Utility of the Neuro‐QoL Cognition Function Scale

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Primary brain tumor (PBT) patients commonly experience cognitive dysfunction. This study aims to describe the prevalence and factors associated with perceived cognitive function (PCF) in PBT patients enrolled in a natural history study (NCT02851706: Principal Investigator T. S. Armstrong).
Morgan Johnson, Kimberly Reinhart, Vivian A. Guedes, Michelle L. Wright, Elizabeth Vera, Alvina Acquaye‐Mallory, Hope Miller, Anna Choi, Tricia Kunst, Jennifer Reyes, Jing Wu, Marta Penas‐Prado, Byram Ozer, Eric Burton, Mark R. Gilbert, Terri S. Armstrong, Tito Mendoza   +16 more
wiley   +1 more source

HBQ1 Acts as a Prognostic Biomarker and Tumor Suppressor Linked to Antigen Presentation in Glioma

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Glioma is a highly aggressive brain tumor associated with substantial morbidity and mortality and with limited treatment options. This study investigates the functional role of Hemoglobin Subunit Theta 1 (HBQ1) in glioma and evaluates its potential as a prognostic biomarker. Using integrated bioinformatics approaches, we demonstrated that HBQ1
Cheng Xie, Qinglin Zhong, Mingang Zou, Qianliang Huang, Lukui Chen, Wenjin Wei   +5 more
wiley   +1 more source

Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma With an Unusual EWSR1::RAD51B Gene Fusion: A Case Report and Review of the Literature. [PDF]

Cureus
Al-Mustafa S, Al-Kawaaz M, Paul L, Franchitti A, Aldape KM, Hattab EM.   +5 more
europepmc   +1 more source

Deepening the Understanding of Platelet‐Derived RNA as Biomarker for Glioblastoma Through GSEA, TDEA, and Elastic Net Regularization Analysis

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Glioblastoma (GBM) is the most aggressive form of primary brain cancer. Blood platelets have emerged as biomarkers where their RNA expression pattern indicates a tumor's presence. Our study aimed to characterize these patterns to identify biological processes associated with GBM and to evaluate their potential as a non‐invasive ...
Anna Giczewska, Krzysztof Pastuszak, Leon van Hout, Edward Post, Jip Ramaker, Ken Zwaan, Anna Supernat, Bart A. Westerman   +7 more
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications. [PDF]

MedComm (2020)
Fang Y, Wang X, Luo K, Dakal TC, Bai H, Xu C, Zhang G.   +6 more
europepmc   +1 more source

Improved Method for Obtaining Patient‐Derived Glioblastoma Organoid and Primary Cells: A Generic and Simplified Approach for Intracranial Tumor With Minimized Input

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
An improved and simplified method enables the generation of primary tumor cells and tumoroids from the same tissue sample with minimal input, applicable universally to both intracranial and spinal tumors. Comparative analysis of drug screening results with patient follow‐up data allows for the assessment of individual drug sensitivity.
Siyuan Wang, Zhonggang Shi, Chihao Zhu, Dawei Dai, Xi Yang, Zhiyi Zhou, Qianying Qiu, Wenhua Sun, Yifeng Miao, Yongming Qiu   +9 more
wiley   +1 more source