Results 141 to 150 of about 190,806 (273)

High‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum

New Phytologist, Volume 252, Issue 3, Page 1215-1231, November 2026.
Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.
Soyoung Choi, Nahyun Lee, Jiyeun Park, Hosung Jeon, Sieun Kim, Jung‐Eun Kim, Jiyoung Shin, Heeji Moon, Kyunghun Min, Yejin Choi, Aram Hwangbo, Hun Kim, Gyung Ja Choi, Yin‐Won Lee, Dae‐Geun Song, Hokyoung Son   +15 more
wiley   +1 more source

Molecular features of intratumoral hemorrhage in glioblastoma isocitrate dehydrogenase-wildtype. [PDF]

J Neurooncol
Bueno A, Dono A, Alcantar O, Amezquita-Contreras C, Ocasio L, Hsu S, Amsbaugh M, Zhu JJ, Blanco AI, Riascos RF, Ballester LY, Tandon N, Esquenazi Y.   +12 more
europepmc   +1 more source

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

Inhibitors of mutant isocitrate dehydrogenase for isocitrate dehydrogenase-mutant gliomas: A new standard of care?

Glioma
Emilie Le Rhun, Zhong-ping Chen, Michael Weller   +2 more
doaj   +1 more source

Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana

Plant, Cell &Environment, Volume 49, Issue 11, Page 9101-9116, November 2026.
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu, Jinhong Liu, Shey‐Li Lim, Jia Yi Zhong, Boon Leong Lim   +4 more
wiley   +1 more source

Methods for assessing binding of a small-molecule radioligand to soluble enzyme isocitrate dehydrogenase 1 variants. [PDF]

EJNMMI Radiopharm Chem
Deuther-Conrad W, Lai TH, Maurer A, Wenzel B.   +3 more
europepmc   +1 more source

Evaluation of early C‐reactive protein kinetics as an early response marker in biliary tract cancer treated with combined chemoimmunotherapy: A multicenter observational study

Cancer, Volume 132, Issue 20, 15 October 2026.
Abstract Background Reliable prognostic biomarkers for treatment response in patients with biliary tract cancer (BTC) who receive chemoimmunotherapy are still lacking. The objective of this study was to evaluate the potential of early C‐reactive protein (CRP) kinetics as a tool for predicting survival in these patients.
Gabriel Allo, Joshua Leutiger, Catherine Leyh, Christian Möhring, Ann‐Kristin Zöller, Vera Himmelsbach, Gianluca Ciarlo, Maryam Barsch, Christoph Neumann‐Haefelin, Bertram Bengsch, Fabian Finkelmeier, Mohamad Murad, Cennet Sahin, Marie‐Luise Berres, Maria A. Gonzalez‐Carmona, Christoph Roderburg, Arndt Weinmann, Anna Saborowski, Arndt Vogel, Dirk Waldschmidt   +19 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Isocitrate Dehydrogenase Mutation Assessment in Human Glioma Using Desorption Electrospray Ionization-Multiple Reaction Monitoring. [PDF]

Anal Chem
Shahi M, Garcia DM, Quiñones-Hinojosa A, Cooks RG.   +3 more
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source