Results 121 to 130 of about 190,806 (273)

Intratumoral IDH1 mutation status in intrahepatic cholangiocarcinoma is homogeneous

Histopathology, EarlyView.
IDH1 mutations are spatially homogeneous in intrahepatic cholangiocarcinoma. Single‐sample molecular testing is sufficient for clinical decision‐making. Introduction IDH1 mutations occur in approximately 10%–20% of intrahepatic cholangiocarcinoma (iCCA) and constitute an established target for molecularly guided therapy.
Sharon Weidmann, Silvana Ebner, Aayushi Srivastava, Armin Wiegering, Stefan Zeuzem, Peter J. Wild, Maximilian N. Kinzler, Melanie C. Winter, Dirk Walter   +8 more
wiley   +1 more source

Isocitrate Dehydrogenase Inhibitors in Glioma: From Bench to Bedside

Pharmaceuticals
Isocitrate dehydrogenase (IDH) mutant gliomas are a primary malignancy of the central nervous system (CNS) malignancies, most commonly affecting adults under the age of 55.
Merve Hazal Ser, Mason Webb, Anna Thomsen, Ugur Sener   +3 more
doaj   +1 more source

THE ENZYMATIC PROPERTIES OF ISOCITRIC DEHYDROGENASE

Journal of Biological Chemistry, 1957
G, Siebert, M, Carsiotis, G W E, Plaut
openaire   +2 more sources

Control of Escherichia coli isocitrate dehydrogenase: an example of protein phosphorylation in a prokaryote

, 1984
In micro-organisms growing on acetate, isocitrate can be metabolized either by the tricarboxylic acid cycle or by the glyoxylate bypass. In Escherichia coli this branch-point is controlled by reversible phosphorylation and inactivation of isocitrate ...
Nimmo, H.G.
core   +1 more source

Light signaling controls chloroplast pyruvate metabolism through the STF1/2–PKP1 module in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, light‐responsive proteins switch on GmPKP1, which boosts chloroplast pyruvate production. This increases pigments, photosynthesis, seed oil, pod number, and yield, revealing a new way that light boosts crop productivity. ABSTRACT Light signaling coordinates plant development with metabolism, but the link between photoreceptors and ...
Faming Lin, Xiaoran Wang, Chenhao Zhao, Shaolong Yang, Jingnan Xu, Hongyi Su, Ruixiang Lei, Yilei Xu, Jike Xue, Ming Chang, Fanjiang Kong, Ran Wang   +11 more
wiley   +1 more source

ESTROGEN-SENSITIVE ISOCITRIC DEHYDROGENASE

Journal of Biological Chemistry, 1957
D D, HAGERMAN, C A, VILLEE
openaire   +2 more sources

TaANT11‐4A enhances grain yield by orchestrating photosynthesis and carbohydrate metabolism through direct transcriptional activation

Journal of Integrative Plant Biology, EarlyView.
TaANT11‐4A is a positive regulator of wheat grain size and yield, directly activating TaEGY2, TaAAE1, and TaAAE2 to enhance photosynthesis and carbohydrate metabolism. The favorable Hap2 haplotype increases TaANT11‐4A expression and grain size, providing a genetic resource for breeding higher‐yielding wheat varieties.
Pengpeng Zhang, Jingjing Wen, Shan Gao, Jiajun Ma, Jiahui Jin, Xiaofei Ma, Wen‐Ting Liu, Juan Li, De‐Jun Han, Yue‐Qiang Zhang, Kun‐Ming Chen   +10 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

Mitochondrial Respiratory Metabolism in Salt‐Stressed Barley (Hordeum vulgare): TCA Cycle Activation With Limited GABA Shunt Engagement

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants maintain energy balance under salinity stress through increased respiration and energy use, processes also associated with reactive oxygen species generation. Although respiration imposes a high energy cost, mitochondrial respiration and the tricarboxylic acid (TCA) cycle activity are vital for ATP production and for providing electron ...
Ali Bandehagh, Nicolas L. Taylor
wiley   +1 more source

Nitroalkylation Mediated by Nitro‐Fatty Acids Is Involved in Key Physiological Processes During Arabidopsis thaliana Development

Plant, Cell &Environment, EarlyView.
ABSTRACT Nitro‐fatty acids (NO2‐FAs) are potent electrophiles that react with nucleophilic residues in proteins (cysteines, histidines and lysines) via a process known as nitroalkylation. This reversible post‐translational modification (PTM) functions as a selective signalling mechanism by modulating the structure, transport, and catalysis of target ...
Lorena Aranda‐Caño, Raquel Valderrama, Mounira Chaki, Juan Carlos Begara‐Morales, José Rafael Pedrajas, Manuel Melguizo, Matín Moret, Aureliano Bombarely, Francisco Luque, Juan Bautista Barroso   +9 more
wiley   +1 more source