Results 111 to 120 of about 403,859 (288)

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis. [PDF]

, 2014
ImportanceWhile "omics" studies have advanced our understanding of inflammatory skin diseases, metabolomics is mostly an unexplored field in dermatology.ObjectiveWe sought to elucidate the pathogenesis of psoriatic diseases by determining the differences
Armstrong, April W, Azizi, Baktazh, Dhillon, Jaskaran, Fiehn, Oliver, Grapov, Dmitry, Johnson, Mary Ann, Wu, Julie   +6 more
core   +2 more sources

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

The Embryonic Transcriptome Of The Red-Eared Slider Turtle (Trachemys Scripta) [PDF]

, 2013
The bony shell of the turtle is an evolutionary novelty not found in any other group of animals, however, research into its formation has suggested that it has evolved through modification of conserved developmental mechanisms.
Cebra-Thomas, J., Chang, Eric Yanbo, , \u2713, Edelman, Hannah Elizabeth, , \u2712, Frick, Melissa Afton, , \u2712, Gilbert, Scott F., Guan, Yin, , \u2713, Hammond, Rebecca Ming, , \u2713, Hampilos, Nicholas Henry, , \u2713, Kaplinsky, Nicholas J., Lilleväli, K., Opoku, David Selassie Bampo, , \u2712, Saare, M., Sariahmed, Karim, , \u2713, Sherman, Eric Alan, , \u2713, Watson, Ray Hess Bair, , \u2713   +14 more
core   +2 more sources

Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study

Head &Neck, EarlyView.
ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange, Mathilde Morisseau, Justin Michel, Thibaut Reverdy, Sylvain Morinière, Amaury Daste, Maxime Humbert, Caroline Viala, Pauline Corbaux, Tiffany Darbas, François‐Régis Ferrand, Valentin Favier, Camille Evrard, Diane Evrard, Delphine Farneti, Sarah Betrian‐Lagarde, Victor Sarradin   +16 more
wiley   +1 more source

Impact of IDH1 Mutation on Long-Term Survival in Patients with Diffuse Glioma

Central Asian Journal of Medical Sciences, 2019
Objectives: Diffuse brain gliomas are common primary brain tumor associated with a poor prognosis. In this study, we aimed to determine the impact of IDH1 mutation status on long term survival.
Enkhee Ochirjav, Tuul Baldandorj, Gheeyoung Choe, Bayarmaa Enkhbat   +3 more
doaj   +1 more source

Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials. [PDF]

, 2013
PurposePatients with advanced cholangiocarcinoma (CC) and gallbladder carcinoma (GC) have few therapeutic options for relapsed disease. methods: Given the overall poor prognosis in this population and the availability of novel targeted therapies, we ...
Falchook, Gerald S, Fu, Siqing, Hess, Kenneth R, Hong, David S, Janku, Filip, Javle, Milind, Kaseb, Ahmed O, Kurzrock, Razelle, Naing, Aung, Piha-Paul, Sarina, Subbiah, Ishwaria M, Subbiah, Vivek, Tsimberidou, Apostolia M, Wheler, Jennifer J, Wolff, Robert A   +14 more
core   +2 more sources

Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions.

Neuro-Oncology, 2022
Julie J. Miller, L. G. Gonzalez Castro, S. McBrayer, M. Weller, T. Cloughesy, J. Portnow, O. Andronesi, J. Barnholtz-Sloan, B. Baumert, M. Berger, W. Bi, R. Bindra, D. Cahill, Susan M. Chang, J. Costello, C. Horbinski, Raymond Y Huang, R. Jenkins, K. Ligon, I. Mellinghoff, L. Nabors, M. Plattén, D. Reardon, D. Shi, D. Schiff, W. Wick, Hai Yan, A. von Deimling, M. J. van den Bent, W. Kaelin, P. Wen   +30 more
semanticscholar   +1 more source

Peptidase Polymorphism in Natural Populations of the Cocoa Pest, Helopeltis theobromae Miller [PDF]

, 1986
Helopeltis theobromae caught off cocoa plants in Kuala Selangor and off Acalypha plants in Serdang, Selangor, Malaysia were investigated electrophoretically for nine biochemical markers: peptidase, a -glycerophosphate dehydrogenase, 6-phosphogluconate ...
Gan, Yik Yuen, Mohd Saahlan, Rusnah, Muhamad Awang, Rita, Tan, Soon Guan   +3 more
core  

Single muscle fiber proteomics reveals unexpected mitochondrial specialization [PDF]

, 2015
Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers according to their contractile and metabolic properties. Here, we developed a high-sensitivity workflow to characterize the proteome of single fibers.
A. S., Deshmukh, Cancellara, Pasqua, I., Moretti, M., Mann, M., Zeiler, Murgia, Marta, N., Nagaraj, Reggiani, Carlo, Schiaffino, Stefano   +8 more
core   +1 more source