Results 131 to 140 of about 190,806 (273)
Experimental Physiology, EarlyView.Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
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The Journal of Physiology, EarlyView.Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma +12 more
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The Journal of Physiology, EarlyView.Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana +2 more
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Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation
The Journal of Physiology, EarlyView.Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min +2 more
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Legume Science, Volume 8, Issue 4, December 2026.ABSTRACT Pea (Pisum sativum) is a nutrient‐rich crop that can provide essential nutrients needed for human and animal health. Improving its mineral concentration through genetic selection can enhance its nutritional value and help combat micronutrient deficiencies. This study aimed to investigate the genetic basis of the accumulation of eight minerals (
Maryam Bagheri +4 more
wiley +1 more source
Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
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Intratumoral and Peritumoral Functional Connectivity Reveals Network‐Level Signatures of Glioma
MedComm, Volume 7, Issue 11, November 2026.Using resting‐state fMRI in 306 glioma patients, this study maps individualized intra‐ and peritumoral functional networks. Novel metrics (RIFR, RPTR) quantify tumor‐related network remodeling, correlating with pathology, structure, cognition, and survival. A prognostic model incorporating these network features achieves an AUC of 0.90.
Hongbo Bao +24 more
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Brain Pathology, Volume 36, Issue 6, November 2026.Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios +18 more
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British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
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