Results 161 to 170 of about 190,806 (273)

Clinical advancement in the management of mutant isocitrate dehydrogenase (<i>IDH</i>) cancers. [PDF]

EJC Suppl
Bridgewater J, Tabatabai G, Macarulla T, Stacchiotti S.   +3 more
europepmc   +1 more source

METTL3 Increases Temozolomide Resistance in MGMT‐Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A‐IGF2BP2‐Dependent Manner

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Hui Deng, Ruoyu Chen, Daohong Qu, Cifu Qu, Jia Shi   +4 more
wiley   +1 more source

Molecular characteristics of isocitrate dehydrogenase 1 R132C-mutant diffuse gliomas: association with TP53 alterations and Li-Fraumeni syndrome. [PDF]

Acta Neuropathol Commun
Yamashita S, Matsumoto F, Saito K, Hidaka M, Arikawa S, Kawano T, Kawano T, Tamura M, Okuyama H, Higa N, Hanaya R, Akahane T, Tanimoto A, Sato Y, Okita Y.   +14 more
europepmc   +1 more source

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Based on the 2021 WHO CNS5 guidelines, this study introduces an integrated high‐risk molecular classification for gliomas and constructs a predictive model by combining multimodal MRI habitat imaging, Transformer‐based WSI pathomics, and clinical information.
Wenju Niu, Xin Duan, Xuan Li, Zehui Li, Qian Liang, Xiangli Yang, Yan Tan, Xiaochun Wang, Guoqiang Yang, Hui Zhang   +9 more
wiley   +1 more source

Vigor tests for evaluation of crambe (Crambe abyssinica Hochst) seed quality

Journal of Seed Science
The aim of this study was adapting the methodology of the accelerated aging test (AA) and electrical conductivity test (EC) to evaluate seed quality of crambe, as well as verifying enzymatic activity in relation to vigor differences. Crambe seed lots, cv.
Sara Michelly Cruz, Marcela Carlota Nery, Adriana de Souza Rocha, Édila Vilela de Resende Von Pinho, Paulo César de Resende Andrade, Denise Cunha Fernandes dos Santos Dias   +5 more
doaj  

Mutations in isocitrate dehydrogenase portend a poor prognosis in adult patients with acute lymphoblastic leukemia. [PDF]

Blood Adv
Goulart H, Short NJ, Borthakur G, Jain N, DiNardo C, Loghavi S, Khouri R, Hachem M, Ravandi F, Daver N, Kadia TM, Yilmaz M, Issa G, Bazinet A, Swaminathan M, Montalban-Bravo G, Haddad F, Garris R, Kantarjian H, Jabbour E.   +19 more
europepmc   +1 more source

Isocitrate dehydrogenase and related oxidative decarboxylases [PDF]

FEBS Letters, 1980
openaire   +2 more sources

Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In gliomas, mitochondria integrate glucose, lipid, protein, and nucleotide metabolism to support proliferation, invasion, treatment resistance, and adaptation, with D‐2‐hydroxyglutarate‐driven remodeling in IDH‐mutant tumors and diverse metabolic states in IDH wild‐type glioblastomas.
Liangqi Jiang, Mingrui Li, Zhen Li, Qing Liu, Yang Li   +4 more
wiley   +1 more source

Right Frontal Isocitrate Dehydrogenase (IDH)-Mutant WHO Grade 3 Oligodendroglioma Presenting With Morning Headache and Gait Imbalance. [PDF]

Cureus
Metwaly L.
europepmc   +1 more source

Isocitrate Dehydrogenase Inhibitor [PDF]

, 2020
openaire   +1 more source