Results 201 to 210 of about 68,056 (282)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, Volume 19, Issue 8, Page 2270-2291, August 2025.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Acute myeloid leukemia treatment outcomes with isocitrate dehydrogenase mutations: A systematic review and meta-analysis. [PDF]

Medicine (Baltimore)
Qin H, Xu R, Yang Y.
europepmc   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, Volume 12, Issue 31, August 21, 2025.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Magnetic resonance diffusion-derived vessel density (DDVD) as a valuable tissue perfusion biomarker for isocitrate dehydrogenase genotyping in diffuse gliomas. [PDF]

BMC Med Imaging
Ni CX, Lin RL, Yao DQ, Ma FZ, Shi YT, He YY, Song Y, Yang G, Jiang RF, Wáng YXJ.   +9 more
europepmc   +1 more source

ON THE MECHANISM OF THE ACONITASE AND ISOCITRIC DEHYDROGENASE REACTIONS

Journal of Biological Chemistry, 1957
Sasha Englard, Sidney P. Colowick
openaire   +3 more sources

Causal Association Between Immune Cell Traits and Risk of Multiple Malignant and Nonmalignant CNS Diseases: A Mendelian Randomization and Single‐Cell Transcriptomic Analysis

Brain and Behavior, Volume 15, Issue 8, August 2025.
This is the graph abstract of our manuscript delineating the methods employed in both MR and scRNA‐seq analyses within the present investigation. ABSTRACT Background The influence of immune cell traits (ICTs) on the onset of multiple brain diseases has been previously investigated; however, it is limited by the sample size or colocalization evidence ...
Shanbao Ke, Junya Yan, Baiyu Li, Xiao Feng   +3 more
wiley   +1 more source

Repurposing the anthelmintic drug mebendazole in combination with radiation therapy in an isocitrate dehydrogenase mutant glioma model. [PDF]

Neurooncol Adv
Yamashita AS, da Costa Rosa M, Riggins GJ.   +2 more
europepmc   +1 more source

Predicting p53 Status in IDH‐Mutant Gliomas Using MRI‐Based Radiomic Model

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Objectives Accurate and noninvasive detection of p53 status in isocitrate dehydrogenase mutant (IDH‐mt) glioma is clinically meaningful for molecular stratification of glioma, yet it remains challenging. We aimed to investigate the diagnostic efficacy of radiomics utilizing pre‐surgery contrast‐enhanced T1‐weighted imaging (CE‐T1WI) for ...
Jiamin Li, Zhihong Lan, Xiao Zhang, Xiaoyun Liang, Hanwei Chen, Xiangrong Yu   +5 more
wiley   +1 more source

Natural language processing algorithms identify wild-type isocitrate dehydrogenase gliomas in electronic health records. [PDF]

Neurooncol Adv
Forrest N, Guggilla V, Bell A, Zelisko S, Federico EM, Power EA, Birch S, Nandoliya KR, Houskamp EJ, Tran S, Lukas RV, Johnson JL, Roy I, Wainwright DA, Walunas TL.   +14 more
europepmc   +1 more source

Some properties of yeast isocitrate dehydrogenase [PDF]

Biochemical Journal, 1972
openaire   +3 more sources