Results 241 to 250 of about 403,859 (288)
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Isocitrate dehydrogenase kinase/phosphatase
Biochimie, 1989In Escherichia coli, isocitrate dehydrogenase (IDH) is regulated by phosphorylation. This phosphorylation cycle is catalyzed by an unusual, bifunctional protein:IDH kinase/phosphatase. IDH kinase/phosphatase is expressed from a single gene, aceK, and both activities are catalyzed by the same polypeptide.
D C, Laporte, C S, Stueland, T P, Ikeda
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Histopathology, 2020
Dedifferentiated chondrosarcoma (DDCHS) is an aggressive type of chondrosarcoma that results from high‐grade transformation of a low‐grade chondrosarcoma. Mutations in the isocitrate dehydrogenase (IDH) 1 gene and the IDH2 gene that lead to increased d‐2‐
Nissreen Mohammad +6 more
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Dedifferentiated chondrosarcoma (DDCHS) is an aggressive type of chondrosarcoma that results from high‐grade transformation of a low‐grade chondrosarcoma. Mutations in the isocitrate dehydrogenase (IDH) 1 gene and the IDH2 gene that lead to increased d‐2‐
Nissreen Mohammad +6 more
semanticscholar +1 more source
The isocitrate dehydrogenase from cyanobacteria
Archives of Microbiology, 1983The present communication describes the properties of isocitrate dehydrogenase in crude extracts from the unicellular Anacystis nidulans and from heterocysts and vegetative cells of Nostoc muscorum and Anabaena cylindrica. The activity levels of this enzyme are much higher in heterocysts than in vegetative cells of N. muscorum and A.
H, Papen, G, Neuer, M, Refaian, H, Bothe
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Isocitrate dehydrogenase of Tetrahymena pyriformis
Molecular and Cellular Biochemistry, 1977We have studied the isocitrate dehydrogenase of Tetrahymena pyriformis. This enzyme is able to utilize both NAD and NADP, but kinetic studies suggest that the enzymatic activity with NAD is not of physiological signifance. Some of the factors that might regualte the NADP-dependent isocitrate dehydrogenase were also studied.
P, Vidal, A, Machado
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Isocitrate dehydrogenase 1 mutations in melanoma frequently co‐occur with NRAS mutations
Histopathology, 2018Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that converts isocitrate to α‐ketoglutarate. IDH1 mutations are associated with the accumulation of the oncometabolite D‐2‐hydroxyglutarate, which acts as an epigenetic modifier, and the development
K. Linos, L. Tafe
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Serum isocitric dehydrogenase and glutamic dehydrogenase in schistosomiasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1969Abstract 19 patients with schistosomiasis were studied for serum ICDH and GLDH activities; they were divided into two groups according to the presence or absence of hepatic involvement. Serum ICDH levels were normal, except in one patient with advanced hepatic decompensation.
Y, Mohran +4 more
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Development of Novel Therapeutics Targeting Isocitrate Dehydrogenase Mutations in Cancer.
Current Topics in Medicinal Chemistry, 2018Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 regulate several cellular processes, including oxidative respiration, glutamine metabolism ...
H. Sharma
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Role of isocitrate dehydrogenase in glioma
Expert Review of Neurotherapeutics, 2011Recently, the isocitrate dehydrogenase (IDH) enzymes have become a focal point for research aimed at understanding the biology of glioma and identifying novel targets for therapy. Following the publication of a landmark genetic sequencing study in 2008, which identified IDH1 as a frequently mutated gene in glioblastoma, much work has been carried out ...
Brian M, Alexander, Minesh P, Mehta
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Isocitric Lyase and Isocitric Dehydrogenase in Germinating Lettuce
Physiologia Plantarum, 1968AbstractA soluble isocitric lyase is shown to occur in lettuce seeds. Its activity increases during germination till 72 hours and then falls again. No particulate lyase could be detected. In addition both a soluble and a particulate isocitric dehydrogenase is present in the seeds. Both enzymes react with NAD as well as with NADP.
A. M. Mayer +2 more
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Mitochondrial Isocitrate Dehydrogenase and Isocitrate Oxidation of Rat Ventral Prostate
Enzyme, 1976Mitochondrial preparations isolated from rat ventral prostate were capable of oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NAD-IDH. NAD-IDH activity required ADP for activation. The pH responses for NAD-IDH and NADP-IDH were quite different.
L C, Costello, R, Franklin, R, Stacey
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