Results 121 to 130 of about 693,247 (202)

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

7-T MRI intratumoral susceptibility signals reflect biomarker status in gliomas

European Radiology Experimental
Objective To evaluate whether 7-T susceptibility-weighted imaging (SWI) can predict glioma’s histological grade, Ki-67 labeling index (LI), isocitrate dehydrogenase 1 (IDH1) mutation, 1p/19q co-deletion, telomerase reverse transcriptase (TERT) promoter ...
Fengwei Yu, Ke Li, Zilong Li, Suyi Zhou, Wei Chen, Chaodong Xiang, Jiafei Chen, Zhentao Zuo, Zhiming Zhen, Wei Chen   +9 more
doaj   +1 more source

Isocitrate dehydrogenase mutations as potential tumour agnostic targets

EJC Supplements
The isocitrate dehydrogenase (IDH) family of proteins comprises three important metabolic enzymes that convert isocitrate to alpha ketoglutarate (α-KG) via oxidative decarboxylation.
Teresa Macarulla, Ghazaleh Tabatabai, Silvia Stacchiotti, John Bridgewater   +3 more
doaj   +1 more source

Gamma distribution model of diffusion MRI for evaluating the isocitrate dehydrogenase mutation status of glioblastomas. [PDF]

Br J Radiol, 2022
Takase H, Togao O, Kikuchi K, Hata N, Hatae R, Chikui T, Tokumori K, Kami Y, Kuga D, Sangatsuda Y, Mizoguchi M, Hiwatashi A, Ishigami K.   +12 more
europepmc   +1 more source

Absence of R140Q mutation of isocitrate dehydrogenase 2 in gliomas and breast cancers

, 2010
International audienceSomatic mutations of isocitrate dehydrogenase (IDH)-1 and IDH2 proteins have been described in gliomas. The mutations target the R132 amino acid residue and the R172 residue in IDH1 and IDH2, respectively.
Mozziconacci, Marie-Joelle, Chinot, Olivier, DANIEL BIRNBAUM, Adélaïde, José, Metellus, Philippe, Carbuccia, Nadine, Figarella-Branger, Dominique, OLIVIER CHINOT, DOMINIQUE FIGARELLA-BRANGER, Raynaud, Stéphane, JOSÉ ADÉLAÏDE, NADINE CARBUCCIA, CAROLE COLIN, MAX CHAFFANET, MARIE-JOELLE MOZZICONACCI, Chaffanet, Max, PHILIPPE METELLUS, STÉPHANE RAYNAUD, Birnbaum, Daniel, Colin, Carole   +19 more
core   +1 more source

Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana

Plant, Cell &Environment, Volume 49, Issue 11, Page 9101-9116, November 2026.
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu, Jinhong Liu, Shey‐Li Lim, Jia Yi Zhong, Boon Leong Lim   +4 more
wiley   +1 more source

Evaluation of isocitrate dehydrogenase mutation in 2021 world health organization classification grade 3 and 4 glioma adult-type diffuse gliomas with 18F-fluoromisonidazole PET. [PDF]

Jpn J Radiol, 2023
Wang Y, Fushimi Y, Arakawa Y, Shimizu Y, Sano K, Sakata A, Nakajima S, Okuchi S, Hinoda T, Oshima S, Otani S, Ishimori T, Tanji M, Mineharu Y, Yoshida K, Nakamoto Y.   +15 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Vessel Size Imaging is Associated with IDH Mutation and Patient Survival in Diffuse Lower-Grade Glioma

Cancer Management and Research, 2020
Houyi Kang,1,2,* Peng Chen,1,2,* Hong Guo,1,2 Letian Zhang,1,2 Yong Tan,1,2 Hualiang Xiao,3 Ao Yang,4 Jingqin Fang,1,2 Weiguo Zhang1,2 1Department of Radiology, Daping Hospital, Army Medical University, Chongqing 400042, People’s Republic of China;
Kang H, Chen P, Guo H, Zhang L T, Tan Y, Xiao H, Yang A, Fang J, Zhang W G   +8 more
doaj