Results 131 to 140 of about 693,247 (202)

The diagnostic value of ADC histogram and direct ADC measurements for coexisting isocitrate dehydrogenase mutation and O6-methylguanine-DNA methyltransferase promoter methylation in glioma. [PDF]

Front Neurosci, 2022
Xie Z, Li J, Zhang Y, Zhou R, Zhang H, Duan C, Liu S, Niu L, Zhao J, Liu Y, Song S, Liu X.   +11 more
europepmc   +1 more source

Factors Associated With Perceived Cognitive Dysfunction in Patients With Primary Brain Tumors: The Utility of the Neuro‐QoL Cognition Function Scale

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Primary brain tumor (PBT) patients commonly experience cognitive dysfunction. This study aims to describe the prevalence and factors associated with perceived cognitive function (PCF) in PBT patients enrolled in a natural history study (NCT02851706: Principal Investigator T. S. Armstrong).
Morgan Johnson, Kimberly Reinhart, Vivian A. Guedes, Michelle L. Wright, Elizabeth Vera, Alvina Acquaye‐Mallory, Hope Miller, Anna Choi, Tricia Kunst, Jennifer Reyes, Jing Wu, Marta Penas‐Prado, Byram Ozer, Eric Burton, Mark R. Gilbert, Terri S. Armstrong, Tito Mendoza   +16 more
wiley   +1 more source

Deepening the Understanding of Platelet‐Derived RNA as Biomarker for Glioblastoma Through GSEA, TDEA, and Elastic Net Regularization Analysis

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Glioblastoma (GBM) is the most aggressive form of primary brain cancer. Blood platelets have emerged as biomarkers where their RNA expression pattern indicates a tumor's presence. Our study aimed to characterize these patterns to identify biological processes associated with GBM and to evaluate their potential as a non‐invasive ...
Anna Giczewska, Krzysztof Pastuszak, Leon van Hout, Edward Post, Jip Ramaker, Ken Zwaan, Anna Supernat, Bart A. Westerman   +7 more
wiley   +1 more source

Deep learning for prediction of isocitrate dehydrogenase mutation in gliomas: a critical approach, systematic review and meta-analysis of the diagnostic test performance using a Bayesian approach. [PDF]

Quant Imaging Med Surg, 2022
Karabacak M, Ozkara BB, Mordag S, Bisdas S.   +3 more
europepmc   +1 more source

Improved Method for Obtaining Patient‐Derived Glioblastoma Organoid and Primary Cells: A Generic and Simplified Approach for Intracranial Tumor With Minimized Input

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
An improved and simplified method enables the generation of primary tumor cells and tumoroids from the same tissue sample with minimal input, applicable universally to both intracranial and spinal tumors. Comparative analysis of drug screening results with patient follow‐up data allows for the assessment of individual drug sensitivity.
Siyuan Wang, Zhonggang Shi, Chihao Zhu, Dawei Dai, Xi Yang, Zhiyi Zhou, Qianying Qiu, Wenhua Sun, Yifeng Miao, Yongming Qiu   +9 more
wiley   +1 more source

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia.

, 2011
Although the clinical features of the Isocitrate dehydrogenase 2 (IDH2) mutation in acute myeloid leukemia (AML) have been characterized, its prognostic significance remains controversial and its stability has not been investigated.
Chou WC; Lei WC; Ko BS; Hou HA; Chen CY; Tang JL; Yao M; Tsay W; Wu SJ; Huang SY; Hsu SC; Chen YC; Chang YC; Kuo KT; Lee FY; Liu MC; Liu CW; Tseng MH; Huang CF; Tien HF
core   +1 more source

N6-methyladenosine-related microRNAs risk model trumps the isocitrate dehydrogenase mutation status as a predictive biomarker for the prognosis and immunotherapy in lower grade gliomas. [PDF]

Explor Target Antitumor Ther, 2022
Yuan F, Wang Y, Cai X, Du C, Zhu J, Tang C, Yang J, Ma C.   +7 more
europepmc   +1 more source

METTL3 Increases Temozolomide Resistance in MGMT‐Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A‐IGF2BP2‐Dependent Manner

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Hui Deng, Ruoyu Chen, Daohong Qu, Cifu Qu, Jia Shi   +4 more
wiley   +1 more source

Visualization of tumor heterogeneity and prediction of isocitrate dehydrogenase mutation status for human gliomas using multiparametric physiologic and metabolic MRI. [PDF]

Sci Rep, 2022
Hagiwara A, Tatekawa H, Yao J, Raymond C, Everson R, Patel K, Mareninov S, Yong WH, Salamon N, Pope WB, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM.   +13 more
europepmc   +1 more source

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Based on the 2021 WHO CNS5 guidelines, this study introduces an integrated high‐risk molecular classification for gliomas and constructs a predictive model by combining multimodal MRI habitat imaging, Transformer‐based WSI pathomics, and clinical information.
Wenju Niu, Xin Duan, Xuan Li, Zehui Li, Qian Liang, Xiangli Yang, Yan Tan, Xiaochun Wang, Guoqiang Yang, Hui Zhang   +9 more
wiley   +1 more source