Isocitrate Lyase and Succinate Semialdehyde Dehydrogenase Mediate the Synthesis of α-Ketoglutarate in Pseudomonas fluorescens [PDF]
Frontiers in Microbiology, 2019 Glycerol is an important by-product of the biodiesel industry and its transformation into value-added products like keto acids is being actively pursued in order to improve the efficacy of this renewable energy sector.
Azhar A. Alhasawi +7 more
doaj +5 more sources
Discovery of a Novel Inhibitor Structure of Mycobacterium tuberculosis Isocitrate Lyase [PDF]
Molecules, 2022 Tuberculosis remains a global threat to public health, and dormant Mycobacterium tuberculosis leads to long-term medication that is harmful to the human body. M. tuberculosis isocitrate lyase (MtICL), which is absent in host cells, is a key rate-limiting
Changyuan Duan +6 more
doaj +3 more sources
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2 [PDF]
Nature Communications, 2019 Isocitrate lyase (ICL) isoforms 1 and 2 are enzymes in the glyoxylate and methylcitrate cycles that enable Mycobacterium tuberculosis (Mtb) to use lipids as a carbon source.
Ram Prasad Bhusal +7 more
doaj +3 more sources
Isocitrate lyase plays important roles in plant salt tolerance [PDF]
BMC Plant Biology, 2019 Background Isocitrate lyase (ICL) is a key enzyme in the glyoxylate cycle. In a previous study in rice, the expression of the ICL-encoding gene (OsICL) was highly induced by salt stress and its expression was enhanced in transgenic rice lines ...
Worawat Yuenyong +3 more
doaj +3 more sources
Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase. [PDF]
Sci Rep, 2020 Pulmonary tuberculosis, caused by Mycobacterium tuberculosis, is one of the most persistent diseases leading to death in humans. As one of the key targets during the latent/dormant stage of M.
Ibeji CU +5 more
europepmc +4 more sources
Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors. [PDF]
Medchemcomm, 2017 The enzymes isocitrate lyase (ICL) isoforms 1 and 2 are essential for Mycobacterium tuberculosis survival within macrophages during latent tuberculosis (TB).
Bhusal RP +7 more
europepmc +4 more sources
Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans [PDF]
Molecules, 2019 The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase, and plays an important role in the pathogenesis of microorganisms during infection.
Heegyu Kim +3 more
doaj +3 more sources
RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the control of
Elias Abdou +8 more
doaj +4 more sources
In Silico Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa [PDF]
Molecules, 2018 Buruli ulcer (BU) is caused by Mycobacterium ulcerans and is predominant in both tropical and subtropical regions. The neglected debilitating disease is characterized by chronic necrotizing skin lesions attributed to a mycolactone, which is a macrolide ...
Samuel K. Kwofie +9 more
doaj +3 more sources
Characterization of a Functional Role of the Bradyrhizobium japonicum Isocitrate Lyase in Desiccation Tolerance. [PDF]
Int J Mol Sci, 2015 Bradyrhizobium japonicum is a nitrogen-fixing symbiont of soybean. In previous studies, transcriptomic profiling of B. japonicum USDA110, grown under various environmental conditions, revealed the highly induced gene aceA, encoding isocitrate lyase (ICL).
Jeon JM +4 more
europepmc +4 more sources