Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε ...
Martin Krátký +6 more
doaj +1 more source
Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)-benzoates
The development of novel antimicrobial agents represents a timely research topic. Eighteen salicylanilide 4-(trifluoromethyl)benzoates were evaluated against Mycobacterium tuberculosis, M. avium and M.
Jiřina Stolaříková +5 more
doaj +1 more source
Effects of Medium Components on Isocitric Acid Production by Yarrowia lipolytica Yeast
The microbiological production of isocitric acid (ICA) is more preferable for its application in medicine and food, because the resulting product contains only the natural isomer—threo-DS.
Svetlana V. Kamzolova +3 more
doaj +1 more source
The Purification and Properties of Yeast Isocitric Lyase [PDF]
SUMMARY 1. Isocitric lyase, which catalyzes the reversible cleavage of L,-isocitrate to glyoxylate and succinate, has been identified in a number of molds, and has been purified 70-fold from yeast autolysates. 2. The purified yeast enzyme acts only on n.-isocitric acid and requires magnesium and cysteine for activity.
openaire +2 more sources
The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence [PDF]
Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology ...
A Brand +75 more
core +4 more sources
Regulation of Autotrophic and Heterotrophic Metabolism in Pseudomonas oxalaticus OX1:Growth on Mixtures of Acetate and Formate in Continuous Culture [PDF]
Growth of Pseudomonas oxalaticus in carbon- and energy-limited continuous cultures with mixtures of acetate and formate resulted in the simultaneous utilization of both substrates at all dilution rates tested.
Dijkhuizen, L., Harder, W.
core +1 more source
Recent data indicate that the metabolism of Mycobacterium tuberculosis (Mtb) inside its host cell is heavily dependent on cholesterol and fatty acids. Mtb exhibits a unique capacity to co-metabolize different carbon sources and the products from these ...
Wonsik Lee +3 more
doaj +1 more source
Handroanthus serratifolius seeds are considered orthodox and have some mechanisms that assist in desiccation tolerance, like heat-resistant proteins and the presence of protective systems against free radical production.
Leandra Helena do Nascimento Gonçalves +5 more
doaj +1 more source
Nuclear mutations affecting mitochondrial structure and function in Chlamydomonas [PDF]
Wild type cells of the green alga Chlamydomonas reinhardtii can grow in the in the dark by taking up and respiring exogenously supplied acetate. Obligate photoautotrophic (dark dier, dk) mutants of this alga have been selected which grow at near wild ...
Boynton, J. E. +2 more
core +1 more source
Control of Isocitrate Lyase in Nocardia salmonicolor (NCIB9701) [PDF]
Nocardia salmonicolor, grown on acetate, commercial D,L-lactate or hydrocarbon substrates, has high isocitrate lyase activities compared with those resulting from growth on other carbon sources. This presumably reflects the anaplerotic role of the glyoxylate cycle during growth on the former substrates.
F S Sariaslani +2 more
openaire +3 more sources

