Results 81 to 90 of about 18,230 (249)

Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis [PDF]

, 2018
Metabolic networks in biological systems are interconnected, such that malfunctioning parts can be corrected by other parts within the network, a process termed adaptive metabolism.
A Belley, A Blumenthal, AA Velayati, AJ Olive, AL Sorensen, AM Szabo, B Dey, BL Bearson, C Feehily, C Maksymiuk, D Charlet, D Schnappinger, DG Russell, DM Hunt, DR Sherman, E Layre, E Layre, EJ Munoz-Elias, EJ Munoz-Elias, FX Berthet, G Lamichhane, H Eoh, H Eoh, H Richard, I Smith, J Marrero, J Marrero, J Monk, J Stelling, JL Gallant, JM Grange, JW Choi, K Rhee, KA Karatzas, KM Guinn, KN Lewis, KY Rhee, LA Keating, LP Carvalho de, LP Carvalho de, LP Carvalho de, M Gengenbacher, M Nandakumar, M Nandakumar, MA Behr, MA Kohanski, MC Garcia Pelayo, MI Hood, MV Fonseca, NR Gandhi, OH Vandal, PD Cotter, R Brosch, R Brosch, R Narayanaswamy, S Mostowy, S Puckett, S Puckett, S Savvi, SA Stanley, ST Cole, T Garnier, T Hsu, T Noy, TA Gianoulis, TA Gould, U Ganapathy, V Saini, W Eisenreich, W Lee, Y Abu Kwaik, Y Kim, YJ Zhang   +72 more
core   +2 more sources

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Purification and characterization of Acinetobacter calcoaceticus isocitrate lyase [PDF]

Journal of Bacteriology, 1991
Acinetobacter calcoaceticus is capable of growing on acetate or compounds that are metabolized to acetate. During adaptation to growth on acetate, A. calcoaceticus B4 exhibits an increase in NADP(+)-isocitrate dehydrogenase and isocitrate lyase activities. In contrast, during adaptation to growth on acetate, Escherichia coli exhibits a decrease in NADP(
J C Hoyt, K E Johnson, Henry C. Reeves
openaire   +3 more sources

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Effects of inhibition of Janus kinase signalling during controlled mechanical ventilation on the rate of skeletal muscle protein synthesis

The Journal of Physiology, EarlyView.
Abstract figure legend 2H2O labelling was used to examine muscle protein fractional synthesis rates (FSR) in an intensive care unit (ICU) model and non‐anaesthetized control rats, and to compare the effects of a Janus kinase (JAK)/STAT inhibitor on protein FSR in the ICU model.
William J. Evans, Mahalakshmi Shankaran, Lars Larsson, Nicola Cacciani, Yvette Hedström, James L. Kirkland, Tamar Tchkonia, Hussein Mohammed, Tyler Field, Marc K. Hellerstein   +9 more
wiley   +1 more source

New Benzoxazine Secondary Metabolites from an Arctic Actinomycete

Marine Drugs, 2014
Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain.
Kyuho Moon, Chan-Hong Ahn, Yoonho Shin, Tae Hyung Won, Keebeom Ko, Sang Kook Lee, Ki-Bong Oh, Jongheon Shin, Seung-Il Nam, Dong-Chan Oh   +9 more
doaj   +1 more source

Distinction between Isocitrate Lyase and Methylisocitrate Lyase inCandida lipolytica [PDF]

Agricultural and Biological Chemistry, 1976
Examination of DEAE-cellulose chromatography clearly demonstrated the presence of the enzyme cleaving 2-methylisocitrate into pyruvate plus succinate in the methylcitric acid cycle. The enzyme differed from the usual isocitrate lyase of Candida lipolytica, and was herein given the trivial name of methylisocitrate lyase.
Takayori Satoh, Takeshi Tabuchi
openaire   +3 more sources

The Roles of Carbon‐Nitrogen Synergy and Phosphate Regulation in Producing Higher Yield of Vancomycin by Amycolatopsis orientalis

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Systematic media optimization in Amycolatopsis orientalis identified maltodextrin, soy‐based nitrogen sources, and phosphate regulation as key drivers of vancomycin yield. Knockout and feeding trials demonstrated essential nutrient roles, offering a cost‐effective, scalable strategy for enhanced antibiotic production.
Vineeth Mani, Sivakamavalli Jeyachandran, Mohammed Aman   +2 more
wiley   +1 more source

Protein crystal growth in low gravity [PDF]

A study is presented of the crystallization of isocitrate lyase (ICL) and the influence of the lack of thermal solutal convection in microgravity on the morphology of ICL crystals is discussed.
Feigelson, Robert S.
core   +4 more sources

Molecular characterisation of radish cultivars

Revista Ciência Agronômica
The radish has been gaining importance in the Brazilian market due to its use as a green manure and cover crop, and also due to its potential for the production of biodiesel, however there are only two registered cultivars, which are morphologically very
Sara Michelly Cruz, Marcela Carlota Nery, Édila Vilela de Resende Von Pinho, Marcelo Luiz de Laia   +3 more
doaj   +1 more source