Results 41 to 50 of about 63,048 (251)

A comparative study on the effects of heat, ultrasound and high hydrostatic pressure on the structural and physicochemical properties of whey proteins

Applied Food Research
This study aimed to investigate the structural changes of whey protein isolate (WPI) caused by high intensity ultrasound (US), high hydrostatic pressure (HHP), and heat (HE), and their impact on important techno-functional properties such as solubility ...
Sara Keshvari Khojasteh, Rassoul Kadkhodaee, Christos Ritzoulis, Zahra Emam-Djomeh, Bahareh Emadzadeh   +4 more
doaj   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design

Advanced Science, EarlyView.
This study reveals how surfactant‐driven interfacial design governs the assembly and stability of protein@MOF composites. Using lipid‐based nonionic surfactants, we modulate protein–MOF interactions to improve encapsulation efficiency, MOF crystallization, and catalytic performance.
Ehsan Rashidniyaghi, Mohammad Khavani, Carlie Coerver, Ruibin Liang, Raheleh Ravanfar   +4 more
wiley   +1 more source

A new paradigm for optimized experimental design in cIEF platforms aimed at an accurate robust and reliable mAbs charge-variant assessment

Scientific Reports
The success of therapeutic monoclonal antibodies (mAbs) and their biosimilars, highlights the challenge to control their purity, identity, and stability.
Marcello Belfiore, Alessandro Ascione, Virginia Ghizzani, Sabrina Di Meo, Francesca Luciani   +4 more
doaj   +1 more source

Computational modeling of distribution coefficients and their correlations with pharmacokinetic properties of 17α-picolyl and 17(E)-picolinylidene androstane derivatives [PDF]

Acta Periodica Technologica, 2019
The present study describes the computational modeling of distribution coefficient (logD) of 17α-picolyl and 17(E)-picolinylidene androstane derivatives, as a group of compounds with significant anticancer activities.
Kovačević Strahinja Z., Karadžić-Banjac Milica Ž., Podunavac-Kuzmanović Sanja O., Ajduković Jovana J.   +3 more
doaj   +1 more source

Physico-Chemical Properties of Collagen Hydrolysates and Their Application in Skin Care Cosmetics

Учёные записки Казанского университета: Серия Естественные науки, 2023
Collagen is a biodegradable polymer with many beneficial properties, such as high biocompatibility with skin, excellent film-forming ability, antimicrobial and antioxidant actions, etc.
S. A. Bogdanova, M. A. Sysoeva, Yu. A. Shigabieva   +2 more
doaj   +1 more source

ZrO2 Aerogel‐Supported Pd Nanoparticles for Photothermal CO2 Reduction

Advanced Science, EarlyView.
Nanoparticle‐based aerogels are promising catalysts for photothermal reactions due to optical transparency, high surface area, and low thermal conductivity. Here, we present deposition of Pd nanoparticles on ZrO2 aerogel granules by a wet‐impregnation approach.
David Kiwic, Linard Räz, Elena Tervoort, Markus Niederberger   +3 more
wiley   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

The Isoelectric Point of Lead Magnesium Niobate [PDF]

Journal of the American Ceramic Society, 2007
Lead magnesium niobate (PMN) is an important relaxor ferroelectric material commonly used in multilayer capacitor and actuator manufacturing owing to its high dielectric constant and superior electrostrictive properties.
Polat, Mehmet, ÇELİK, ERDAL, Deliormanli, Aylin M.   +2 more
openaire   +4 more sources