Results 91 to 100 of about 37,345 (206)

Protective Effect of Isoflurane on Hypoxia/Reoxygenation‐Induced Myocardial Injury via miR‐548a‐5p Regulation of PTEN

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
H/R injury downregulates miR‑548a‑5p and upregulates its direct target PTEN in H9c2 cardiomyocytes, triggering reduced cell viability, elevated apoptosis, oxidative stress and myocardial injury marker release. 1.0% isoflurane (ISO) pretreatment reverses these pathological alterations by elevating miR‑548a‑5p and repressing PTEN.
Ji Yao, Jianyong Zheng, Wei Wei
wiley   +1 more source

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

open access: yesImmunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutaminase enzymes, leading to ...
Aïsha Callebaut   +4 more
wiley   +1 more source

Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

open access: yesChemMedChem, Volume 21, Issue 13, 14 July 2026.
Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak   +8 more
wiley   +1 more source

Berberine and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Hope or Hype?

open access: yes
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
Ruth Nona, Eric Kalo
wiley   +1 more source

Engineering of Amygdalin Biosynthesis in Rice Endosperm for Pharmaceutical Production and Sitophilus oryzae Resistance

open access: yes
Plant Biotechnology Journal, Volume 24, Issue 8, Page 4860-4862, August 2026.
Ke Chen   +16 more
wiley   +1 more source

Benign Transient Hyperphosphatasemia in Adults: Case Report and Literature Review. [PDF]

open access: yesHCA Healthc J Med
Rodriguez Castro JL   +3 more
europepmc   +1 more source

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