Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne +22 more
wiley +1 more source
Screening Study of the Inhibitory Effects 17 Steroids on 6 Major Cytochrome P450 Isoenzymes
, 2001 Objective: To screen the inhibitory effects of 17 steroids on 6 major cytochrome P450 (CYP) isoenzymes. Methods: The inhibitory effects of 17 steroids at 100 μM (25 μM for estrone) were tested towards 6 major CYPs including CYP1A2, CYP2A6, CYP2C9, CYP2D6,
张江伟, 李巍, 刘勇, 杨凌
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Distribution of lactate dehydrogenase isoenzymes in coelomic fluid and fetal adnexae
, 1996 The objective of this study was to evaluate the distribution of lactate dehydrogenase isoenzymes in the human gestational sac. Total lactate dehydrogenase and its isoenzymes were measured in matched coelomic fluid and samples of villous and decidual ...
Jauniaux, E. +3 more
core +1 more source
A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase
Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne +22 more
wiley +1 more source
Method for Isolation of MMP-7-Ase Isoenzymes from Rat Muscle Tissue Extract
, 1988 Two MMP-7-ase isoenzymes were purified 100-fold from rat muscle extract to apparent homogeneity, with an overall yield of 10%, using homogenization, ultracentrifugation, high-performance aqueous size-exclusion and high-performance anion exchange ...
Zarandi, Marta +4 more
core +1 more source
Frequency distributions of (Spearman’s rank) correlations for fast- and slow-evolving isoenzymes.
, 2017 Each isoenzyme in an isoenzyme gene set was categorized as one of: fast-evolving (highest evolutionary rate within the isozyme set), slow-evolving (lowest rate), or neutral.
Christopher Jacobs (3687193) +3 more
core +1 more source
Electrophoresis of isoenzymes of lactate dehydrogenase
, 2010 Tato bakalářská práce se zabývá stanovením izoenzymů laktátdehydrogenázy v lidské plazmě elektroforetickou metodou pomocí diagnostické soupravy HYDRAGEL ISO-LDH K20 (Sebia).
Laláková, Lucie
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Manganese peroxidase isoenzymes produced by Pleurotus ostreatus grown on wood sawdust.
, 2000 The white rot basidiomycete Pleurotus ostreatus produces two manganese peroxidase (MnP) isoenzymes when grown in solid stationary conditions on poplar sawdust, whereas a lower production of these same enzymes is observed on fir sawdust.
FONTANELLA B. +12 more
core +1 more source
Characterization of Equine CYP3A94, CYP3A95 and CYP3A97 Isoenzymes
, 2018 Introduction: CYP3A is a human cytochrome P450 (CYPs) subfamily that catalyzes drug metabolism of more than 50% of on the marketed drugs. In equines, this subfamily is known to share more than 75% sequence identity with
Vimercati, Sara
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Isoenzymes of adenosine deaminase in pleural effusions: A diagnostic tool?
, 1998 SETTING: Tygerberg Hospital, an academic teaching hospital, Republic of South Africa. OBJECTIVE: To identify the adenosine deaminase (ADA) isoenzymes as a diagnostic tool for tuberculosis in pleural effusions with increased ADA activity. DESIGN: Patients
Maritz F.J. +3 more
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