Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment
Cell Death Discovery, 2021 Ferroptosis is a novel type of programmed cell death, which is different from apoptosis and autophagic cell death. Recently, ferroptosis has been indicated to contribute to the in vitro neurotoxicity induced by isoflurane, which is one of the most common
Pengfei Liu +5 more
doaj +2 more sources
Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. [PDF]
PLoS ONE, 2014 Isoflurane in clinical use is a racemate of S- and R-isoflurane. Previous studies have demonstrated that the effects of S-isoflurane on relevant anesthetic targets might be modestly stronger (less than 2-fold) than R-isoflurane.
Weiming Bu +3 more
doaj +6 more sources
Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice. [PDF]
PLoS ONE, 2015 Isoflurane was previously the major clinical anesthetic agent but is now mainly used for veterinary anesthesia. Studies have reported widespread sites of action of isoflurane, suggesting a wide array of side effects besides sedation. In the present study,
Kumiko Yonezaki +6 more
doaj +2 more sources
Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons [PDF]
Frontiers in Cellular Neuroscience, 2014 Commonly used anesthetic isoflurane has been reported to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase-3 activation. However, the up-stream mechanisms of the isoflurane’s effects remain largely to be determined.
Yiying eZhang +9 more
doaj +4 more sources
Frontiers in Medicine, 2021 Objective: Surgery is the first line treatment of colorectal cancer (CRC). Anesthetic isoflurane may improve outcomes of cancer surgery. Herein, we investigated the effects of isoflurane on malignant behaviors of CRC cells and its underlying therapeutic ...
Zhe Cai, Liangyuan Suo, Zeqing Huang
doaj +1 more source
Paired assessment of volatile anesthetic concentrations with synaptic actions recorded in vitro. [PDF]
PLoS ONE, 2008 The volatile anesthetic isoflurane poses a number of experimental challenges in the laboratory. Due to its rapid evaporation, the open conditions of most in vitro electrophysiological recording systems make the determination of actual isoflurane ...
Stuart J McDougall +5 more
doaj +1 more source
The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. [PDF]
PLoS ONE, 2014 Endothelial dysfunction is common in acute and chronic organ injury. Isoflurane is a widely used halogenated volatile anesthetic during the perioperative period and protects against endothelial cell death and inflammation.
Mihwa Kim +4 more
doaj +1 more source
Biomedicines, 2022 The therapeutic effects of volatile anesthetics on mental diseases, particularly schizophrenia, have gained considerable interest. Although isoflurane is a commonly used volatile anesthetic, there’s no more evidence that it could work on treating ...
Hualing Peng +3 more
doaj +1 more source
Isoflurane preconditioning confers cardioprotection by activation of ALDH2. [PDF]
PLoS ONE, 2013 The volatile anesthetic, isoflurane, protects the heart from ischemia/reperfusion (I/R) injury. Aldehyde dehydrogenase 2 (ALDH2) is thought to be an endogenous mechanism against ischemia-reperfusion injury possibly through detoxification of toxic ...
Xiao-E Lang +5 more
doaj +1 more source
Scientific Reports, 2022 Endoplasmic reticulum (ER) stress has been linked to anesthesia-induced neurotoxicity, but melatonin seems to play a protective role against ER stress.
Hyun-Jung Shin +5 more
doaj +1 more source