Results 141 to 150 of about 301,160 (383)

Preferential effect of isoflurane on top-down vs. bottom-up pathways in sensory cortex

Frontiers in Systems Neuroscience, 2014
The mechanism of loss of consciousness (LOC) under anesthesia is unknown. Because consciousness depends on activity in the cortico-thalamic network, anesthetic actions on this network are likely critical for LOC.
A. Raz, S. M. Grady, Bryan M. Krause, D. Uhlrich, K. Manning, M. Banks   +5 more
semanticscholar   +1 more source

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source

Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
It is important to identify the best inspired fraction of oxygen in a variety of situations, including sevoflurane or isoflurane anesthesia, in spontaneously breathing rabbits.
M. Horr, N. Nunes, E.G.F. Biteli, P.C.F. Lopes, A.P. Gering, J.V. Moro, F.D.L. Rocha   +6 more
doaj   +1 more source

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis [PDF]

, 2013
Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin,
Galley, H. F., Lowes, D. A., Murphy, M. P., Webster, N. R.   +3 more
core   +1 more source

Maternal and Fetal Cardiovascular and Acid–Base Changes during Halothane and Isoflurane Anesthesia in the Pregnant Ewe [PDF]

, 1974
Richard J. Palahniuk, Sol M. Shnider
openalex   +1 more source

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

Advanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang   +13 more
wiley   +1 more source

TREK-1 mediates isoflurane-induced cytotoxicity in astrocytes

BMC Anesthesiology, 2017
Background There are growing concerns that anaesthetic exposure can cause extensive apoptotic degeneration of neurons and the impairment of normal synaptic development and remodelling.
Haiyun Guo, Zhengwu Peng, Liu Yang, Xue Liu, Yaning Xie, Yanhui Cai, Lize Xiong, Yi Zeng   +7 more
doaj   +1 more source

Inotropic Effects of Isoflurane on Mechanics of Contraction in Isolated Cat Papillary Muscles from Normal and Failing Hearts [PDF]

, 1973
Osamu Kemmotsu, Yasuhiko Hashimoto, Shiro Shimosato   +2 more
openalex   +1 more source

Sedation with isoflurane [PDF]

Anaesthesia, 1988
I. McLellan, A.P.G. Beechey, D.W. Atherley, J.M. Hull   +3 more
openaire   +3 more sources

Controlled Magnesium Ion Delivery via Mg‐Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
This study introduces a controllable degradation system for Mg‐based biomaterials using sputtering technology, marking a significant advancement in nerve regeneration research. The Mg‐sputtered nerve conduits demonstrate enhanced biocompatibility, biofunctionality, mechanical compatibility, and precise magnesium release, resulting in improved axonal ...
Hyewon Kim, Jieun Kwon, Hyeok Kim, Sunhee Lee, Seongchan Kim, Ji‐Young Lee, Khandoker Asiqur Rahaman, Taeyeon Kim, Hyojin Lee, Myoung‐Ryul Ok, Seok Chung, Hyung‐Seop Han, Yu‐Chan Kim   +12 more
wiley   +1 more source