Results 11 to 20 of about 312,228 (350)

Isoflurane‐induced apoptosis of oligodendrocytes in the neonatal primate brain

Annals of Neurology, 2012
Stephen A Back, Art Riddle
exaly   +3 more sources

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3β pathway.

Molecular Medicine Reports, 2016
Yini Zhang, Zhao Zhang, Haitang Wang, Nan Cai, Shuang Zhou, Yaoping Zhao, Xue Chen, Shaoqiang Zheng, Qi Si, Wei Zhang   +9 more
semanticscholar   +3 more sources

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

Journal of Neuroinflammation, 2022
Background Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity and induces cognitive impairments, but the exact mechanism remains unclear ...
Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liang-yu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, X. Gu   +9 more
semanticscholar   +1 more source

Isoflurane Suppresses Proliferation, Migration, and Invasion and Facilitates Apoptosis in Colorectal Cancer Cells Through Targeting miR-216

Frontiers in Medicine, 2021
Objective: Surgery is the first line treatment of colorectal cancer (CRC). Anesthetic isoflurane may improve outcomes of cancer surgery. Herein, we investigated the effects of isoflurane on malignant behaviors of CRC cells and its underlying therapeutic ...
Zhe Cai, Liangyuan Suo, Zeqing Huang
doaj   +1 more source

Paired assessment of volatile anesthetic concentrations with synaptic actions recorded in vitro. [PDF]

PLoS ONE, 2008
The volatile anesthetic isoflurane poses a number of experimental challenges in the laboratory. Due to its rapid evaporation, the open conditions of most in vitro electrophysiological recording systems make the determination of actual isoflurane ...
Stuart J McDougall, James H Peters, Lia LaBrant, Xin Wang, Dennis R Koop, Michael C Andresen   +5 more
doaj   +1 more source

The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. [PDF]

PLoS ONE, 2014
Endothelial dysfunction is common in acute and chronic organ injury. Isoflurane is a widely used halogenated volatile anesthetic during the perioperative period and protects against endothelial cell death and inflammation.
Mihwa Kim, Ahrom Ham, Katelyn Yu-Mi Kim, Kevin M Brown, H Thomas Lee   +4 more
doaj   +1 more source

Repeated isoflurane exposures of neonatal rats contribute to cognitive dysfunction in juvenile animals: the role of miR-497 in isoflurane-induced neurotoxicity

Folia Histochemica et Cytobiologica, 2021
INTRODUCTION: Isoflurane anesthesia at the period of brain development can lead to neurotoxicity and long-term cognitive impairment. This study aimed to investigate the role of miR-497 on isoflurane-induced neurotoxicity.
Yuanyuan Que, Fangxiang Zhang, Jing Peng, Zhuhua Zhang, Duwen Zhang, Minghai He   +5 more
doaj   +1 more source

Impact of isoflurane on malignant capability of ovarian cancer in vitro

British Journal of Anaesthesia, 2015
X. Luo, X. Luo, Hailin Zhao, L. Hennah, Jiaolin Ning, J. Liu, H. Tu, Daqing Ma   +7 more
exaly   +2 more sources

Isoflurane Rescue Schizophrenia-Related Deficits through Parvalbumin-Positive Neurons in the Dentate Gyrus

Biomedicines, 2022
The therapeutic effects of volatile anesthetics on mental diseases, particularly schizophrenia, have gained considerable interest. Although isoflurane is a commonly used volatile anesthetic, there’s no more evidence that it could work on treating ...
Hualing Peng, Jie Jia, Yisheng Lu, Hua Zheng   +3 more
doaj   +1 more source

Altered Resting-State Functional Connectivity Between Awake and Isoflurane Anesthetized Marmosets.

Cerebral Cortex, 2020
The common marmoset (Callithrix jacchus) is a New World primate that is becoming increasingly popular as a preclinical model. To assess functional connectivity (FC) across the marmoset brain, resting-state functional MRI (RS-fMRI) is often performed ...
Y. Hori, D. Schaeffer, K. Gilbert, Lauren K. Hayrynen, Justine C. Cléry, J. Gati, Ravi S. Menon, S. Everling   +7 more
semanticscholar   +1 more source