Results 11 to 20 of about 221,447 (295)

Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice. [PDF]

PLoS ONE, 2015
Isoflurane was previously the major clinical anesthetic agent but is now mainly used for veterinary anesthesia. Studies have reported widespread sites of action of isoflurane, suggesting a wide array of side effects besides sedation. In the present study,
Kumiko Yonezaki, Kazuhiro Uchimoto, Tomoyuki Miyazaki, Ayako Asakura, Ayako Kobayashi, Kenkichi Takase, Takahisa Goto   +6 more
doaj   +1 more source

Isoflurane Rescue Schizophrenia-Related Deficits through Parvalbumin-Positive Neurons in the Dentate Gyrus

Biomedicines, 2022
The therapeutic effects of volatile anesthetics on mental diseases, particularly schizophrenia, have gained considerable interest. Although isoflurane is a commonly used volatile anesthetic, there’s no more evidence that it could work on treating ...
Hualing Peng, Jie Jia, Yisheng Lu, Hua Zheng   +3 more
doaj   +1 more source

Isoflurane and Carbon Dioxide Elicit Similar Behavioral Responses in Rats

Animals, 2020
Euthanasia in rodents is an ongoing topic of debate due to concerns regarding the aversive nature of gases with anesthetic properties such as carbon dioxide (CO2) and isoflurane.
Satyajit Kulkarni, Debra Hickman
doaj   +1 more source

Isoflurane preconditioning confers cardioprotection by activation of ALDH2. [PDF]

PLoS ONE, 2013
The volatile anesthetic, isoflurane, protects the heart from ischemia/reperfusion (I/R) injury. Aldehyde dehydrogenase 2 (ALDH2) is thought to be an endogenous mechanism against ischemia-reperfusion injury possibly through detoxification of toxic ...
Xiao-E Lang, Xiong Wang, Ke-Rang Zhang, Ji-Yuan Lv, Jian-Hua Jin, Qing-Shan Li   +5 more
doaj   +1 more source

Signatures of Thalamocortical Alpha Oscillations and Synchronization With Increased Anesthetic Depths Under Isoflurane

Frontiers in Pharmacology, 2022
Background: Electroencephalography (EEG) recordings under propofol exhibit an increase in slow and alpha oscillation power and dose-dependent phase–amplitude coupling (PAC), which underlie GABAA potentiation and the central role of thalamocortical ...
Jingyao Jiang, Jingyao Jiang, Yi Zhao, Yi Zhao, Jin Liu, Jin Liu, Yaoxin Yang, Peng Liang, Han Huang, Yongkang Wu, Yi Kang, Tao Zhu, Cheng Zhou   +12 more
doaj   +1 more source

Melatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans

Scientific Reports, 2022
Endoplasmic reticulum (ER) stress has been linked to anesthesia-induced neurotoxicity, but melatonin seems to play a protective role against ER stress.
Hyun-Jung Shin, Bon-Wook Koo, Jiwon Yoon, Heeyeon Kim, Sang-Hwan Do, Hyo-Seok Na   +5 more
doaj   +1 more source

Isoflurane Preconditioning Increases Survival of Rat Skin Random-Pattern Flaps by Induction of HIF-1α Expression

Cellular Physiology and Biochemistry, 2013
Background: Survival of random-pattern skin flaps is important for the success of plastic and reconstructive surgeries. This study investigates isoflurane-induced protection against ischemia of skin flap and the underlying molecular mechanism in this ...
Yu Sun, Qi-Fang Li, Ying Zhang, Rong Hu, Hong Jiang   +4 more
doaj   +1 more source

The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability

iScience, 2020
Summary: Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the neuronal mechanism is unclear.
Mengchan Ou, Wenling Zhao, Jin Liu, Peng Liang, Han Huang, Hai Yu, Tao Zhu, Cheng Zhou   +7 more
doaj   +1 more source

Isoflurane induces learning impairment that is mediated by interleukin 1β in rodents. [PDF]

PLoS ONE, 2012
Postoperative cognitive decline is a clinical syndrome. Volatile anesthetics are commonly used during surgery. It is conceivable that volatile anesthetics may contribute to postoperative cognitive decline.
Lin Cao, Liaoliao Li, Daowei Lin, Zhiyi Zuo   +3 more
doaj   +1 more source

Neuroprotective effects of miR-142-5p downregulation against isoflurane-induced neurological impairment

Diagnostic Pathology, 2020
Background Isoflurane can lead to neuron damage to the developing brain, resulting in learning and memory disability. The aim of this study was to investigate the role of miR-142-5p on isoflurane-induced neurological impairment.
Cuili Xie, Hongyue Wang, Yu Zhang, Yanhua Wei   +3 more
doaj   +1 more source