Results 11 to 20 of about 317,847 (279)
PLoS ONE, 2014 Prolonged exposure to volatile anesthetics, such as isoflurane and sevoflurane, causes neurodegeneration in the developing animal brains. Recent studies showed that dexmedetomidine, a selective α2-adrenergic agonist, reduced isoflurane-induced cognitive ...
Zhiyi Zuo
exaly +2 more sources
Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain [PDF]
British Journal of Anaesthesia, 2017 Kazuma Noguchi +7 more
exaly +2 more sources
Journal of Neuroinflammation, 2022 Background Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity and induces cognitive impairments, but the exact mechanism remains unclear ...
Rui Dong +9 more
semanticscholar +1 more source
Frontiers in Medicine, 2021 Objective: Surgery is the first line treatment of colorectal cancer (CRC). Anesthetic isoflurane may improve outcomes of cancer surgery. Herein, we investigated the effects of isoflurane on malignant behaviors of CRC cells and its underlying therapeutic ...
Zhe Cai, Liangyuan Suo, Zeqing Huang
doaj +1 more source
Paired assessment of volatile anesthetic concentrations with synaptic actions recorded in vitro. [PDF]
PLoS ONE, 2008 The volatile anesthetic isoflurane poses a number of experimental challenges in the laboratory. Due to its rapid evaporation, the open conditions of most in vitro electrophysiological recording systems make the determination of actual isoflurane ...
Stuart J McDougall +5 more
doaj +1 more source
Impact of isoflurane on malignant capability of ovarian cancer in vitro
British Journal of Anaesthesia, 2015 X. Luo +7 more
exaly +2 more sources
The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. [PDF]
PLoS ONE, 2014 Endothelial dysfunction is common in acute and chronic organ injury. Isoflurane is a widely used halogenated volatile anesthetic during the perioperative period and protects against endothelial cell death and inflammation.
Mihwa Kim +4 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2021 INTRODUCTION: Isoflurane anesthesia at the period of brain development can lead to neurotoxicity and long-term cognitive impairment. This study aimed to investigate the role of miR-497 on isoflurane-induced neurotoxicity.
Yuanyuan Que +5 more
doaj +1 more source
Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity [PDF]
Neuroscience Letters, 2007 The commonly used inhaled anesthetic isoflurane has been shown to be both neuroprotective and neurotoxic in various cell cultures and animal models. We hypothesize that, like cerebral ischemia, isoflurane is inherently neurotoxic. Limited exposure of isoflurane provides neuroprotection via induction of endogenous neuroprotective mechanisms ...
Huafeng, Wei, Ge, Liang, Hui, Yang
openaire +2 more sources