Results 11 to 20 of about 301,160 (383)

Ferroptosis Contributes to Isoflurane Neurotoxicity [PDF]

Frontiers in Molecular Neuroscience, 2019
The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form of programmed cell death distinct from apoptosis or autophagy, characterized by iron-dependent reactive oxygen species (ROS) generation secondary to failure of glutathione-dependent antioxidant defenses. The results
Yimeng Xia, Yimeng Xia, Xiaoyun Sun, Yan Luo, Creed M. Stary   +4 more
openaire   +5 more sources

Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells

Acta Biochimica et Biophysica Sinica, 2019
The widely used inhalation anesthetic, isoflurane, potentially induces neuronal injury in clinical practice. Previous studies showed multiple forms of cell death that resulted from isoflurane-induced cytotoxicity, but the precise underlying mechanism ...
Liu Ruizhu, Li Xuefeng, Zhao Guoqing
doaj   +2 more sources

Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats [PDF]

Anesthesia and Analgesia, 2016
BACKGROUND: Although emergence from general anesthesia is clinically treated as a passive process driven by the pharmacokinetics of drug clearance, agents that hasten recovery from general anesthesia may be useful for treating delayed emergence ...
Ba, Demba E, Brown, Emery N., Chemali, Jessica J., Cotten, Joseph F., Kenny, Jonathan D., Kim, Seong-Eun, Solt, Ken, Taylor, Norman E., Van Dort, Christa J.   +8 more
core   +2 more sources

Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress [PDF]

PLoS ONE, 2017
According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia.
Hohlbaum, Katharina, Bert, Bettina, Dietze, Silke, Palme, Rupert, Fink, Heidrun, Thöne-Reineke, Christa   +5 more
core   +2 more sources

Effects of Methadone on the Minimum Anesthetic Concentration of Isoflurane, and Its Effects on Heart Rate, Blood Pressure and Ventilation during Isoflurane Anesthesia in Hens (Gallus gallus domesticus). [PDF]

PLoS ONE, 2016
The aim of this study was to measure the temporal effects of intramuscular methadone administration on the minimum anesthetic concentration (MAC) of isoflurane in hens, and to evaluate the effects of the isoflurane-methadone combination on heart rate and
André Escobar, Rozana Wendler da Rocha, Bruno Henri Pypendop, Darcio Zangirolami Filho, Samuel Santos Sousa, Carlos Augusto Araújo Valadão   +5 more
doaj   +2 more sources

Prostate cancer cell malignancy via modulation of HIF-1 alpha pathway with isoflurane and propofol alone and in combination [PDF]

British Journal of Cancer, 2014
BACKGROUND: Surgery is considered to be the first line treatment for solid tumours. Recently, retrospective studies reported that general anaesthesia was associated with worse long-term cancer-free survival when compared with regional anaesthesia.
A Gottschalk, A Gottschalk, A Heaney, A Kushida, AE Greijer, AK Exadaktylos, AN Tavare, B Biki, B Biki, B Welden, BH Jiang, C Bevan, CA Deegan, CC Liang, CH Yeh, D Liao, D Ma, D Ma, E Monti, F Bray, G Semenza, GL Semenza, GL Semenza, GL Semenza, GS de Oliveira Jr, H Daijo, H Huang, H R Watts, H Wang, H Wei, H Wei, H Zhao, HS Ban, J Hu, JT Taylor, K Gupta, K Talks, K Tsuda, L Gopinathan, L L Benzonana, L Lin, L Terraneo, LL Benzonana, N Burrows, N Fujioka, N J S Perry, PE Bickler, PE Bickler, PS Garcia, QF Li, R Brown, R Christopherson, S Shukla, S Takabuchi, S Takabuchi, T Mammoto, T Tanaka, TM Smul, TS Eisinger-Mathason, WK Xin, XF Ren, Y Zhang, Z Zuo   +62 more
core   +3 more sources

ISOFLURANE

British Journal of Anaesthesia, 1981
The introduction of isoflurane to clinical practice follows the search for a nonflammable, potent inhalation anesthetic which, above all, is chemically stable so as to resist biodegradation or attack by other chemicals. These attributes characterize isoflurane (Table 2).
Wendell C. Stevens, John G. Wade
  +11 more sources

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

Journal of Neuroinflammation, 2022
Background Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity and induces cognitive impairments, but the exact mechanism remains unclear ...
Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liang-yu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, X. Gu   +9 more
semanticscholar   +1 more source

Isoflurane in labour [PDF]

Anaesthesia, 1993
SummaryA comparison of the analgesic efficacy of Entonox (50% nitrous oxide in oxygen) and Entonox with 0.2% isofturane was made in 18 consenting mothers during the first stage of labour. The inhalational gases were self‐administered during contractions over a 3 h study period using a standard Entonox demand valve and breathing system.
M. A. Hasan, T. A. Thomas, M. Y. K. Wee
openaire   +3 more sources

Altered Resting-State Functional Connectivity Between Awake and Isoflurane Anesthetized Marmosets.

Cerebral Cortex, 2020
The common marmoset (Callithrix jacchus) is a New World primate that is becoming increasingly popular as a preclinical model. To assess functional connectivity (FC) across the marmoset brain, resting-state functional MRI (RS-fMRI) is often performed ...
Y. Hori, D. Schaeffer, K. Gilbert, Lauren K. Hayrynen, Justine C. Cléry, J. Gati, Ravi S. Menon, S. Everling   +7 more
semanticscholar   +1 more source