Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment
Cell Death Discovery, 2021 Ferroptosis is a novel type of programmed cell death, which is different from apoptosis and autophagic cell death. Recently, ferroptosis has been indicated to contribute to the in vitro neurotoxicity induced by isoflurane, which is one of the most common
Pengfei Liu
exaly +3 more sources
Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress [PDF]
PLoS ONE, 2017 According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia.
Katharina Hohlbaum +2 more
exaly +4 more sources
Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. [PDF]
PLoS ONE, 2014 Isoflurane in clinical use is a racemate of S- and R-isoflurane. Previous studies have demonstrated that the effects of S-isoflurane on relevant anesthetic targets might be modestly stronger (less than 2-fold) than R-isoflurane.
Weiming Bu +3 more
doaj +10 more sources
Ferroptosis Contributes to Isoflurane Neurotoxicity [PDF]
Frontiers in Molecular Neuroscience, 2019 The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form of programmed cell death distinct from apoptosis or autophagy, characterized by iron-dependent reactive oxygen species (ROS) generation secondary to failure of glutathione-dependent antioxidant defenses. The results
Yimeng Xia +4 more
openaire +5 more sources
Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats [PDF]
Anesthesia and Analgesia, 2016 BACKGROUND: Although emergence from general anesthesia is clinically treated as a passive process driven by the pharmacokinetics of drug clearance, agents that hasten recovery from general anesthesia may be useful for treating delayed emergence ...
Ba, Demba E +8 more
core +2 more sources
Acta Biochimica et Biophysica Sinica, 2019 The widely used inhalation anesthetic, isoflurane, potentially induces neuronal injury in clinical practice. Previous studies showed multiple forms of cell death that resulted from isoflurane-induced cytotoxicity, but the precise underlying mechanism ...
Liu Ruizhu, Li Xuefeng, Zhao Guoqing
doaj +2 more sources
Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice. [PDF]
PLoS ONE, 2015 Isoflurane was previously the major clinical anesthetic agent but is now mainly used for veterinary anesthesia. Studies have reported widespread sites of action of isoflurane, suggesting a wide array of side effects besides sedation. In the present study,
Kumiko Yonezaki +6 more
doaj +2 more sources
Time-Dependent Effects of Anesthetic Isoflurane on Reactive Oxygen Species Levels in HEK-293 Cells [PDF]
Brain Sciences, 2014 The inhalation anesthetic isoflurane has been reported to induce caspase activation and apoptosis, which may lead to learning and memory impairment. However, the underlying mechanisms of these effects are largely unknown.
Yongxing Sun +5 more
doaj +4 more sources
Effects of Methadone on the Minimum Anesthetic Concentration of Isoflurane, and Its Effects on Heart Rate, Blood Pressure and Ventilation during Isoflurane Anesthesia in Hens (Gallus gallus domesticus). [PDF]
PLoS ONE, 2016 The aim of this study was to measure the temporal effects of intramuscular methadone administration on the minimum anesthetic concentration (MAC) of isoflurane in hens, and to evaluate the effects of the isoflurane-methadone combination on heart rate and
André Escobar +5 more
doaj +2 more sources
British Journal of Cancer, 2014 Background:Surgery is considered to be the first line treatment for solid tumours. Recently, retrospective studies reported that general anaesthesia was associated with worse long-term cancer-free survival when compared with regional anaesthesia.
, Charlotte Bevan
exaly +2 more sources