Results 121 to 130 of about 2,609,725 (348)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Chemical Constituents From the Leaves of Gagn. and Their Cytotoxic Activity

Natural Product Communications
Objective: The ultimate objective of this study was to isolate bioactive compounds from Grewia bulot Gagn. leaves and evaluate their cytotoxicity against a panel of human cancer cell lines.
Ty Viet Pham, Duc Viet Ho, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Ninh The Son, Anh Tuan Le, Bao Chi Nguyen   +7 more
doaj   +1 more source

Kaempferol and Quercetin Isolated from The Leaves of Atingia Excelsa to Arrest Cell Cycle in G0/G1 Phase Human Tongue Cancer SP-C1 Cell Lines

, 2021
Risyandi Anwar, Arlétte Suzy Setiawan, Supriatno, Unang Supratman   +3 more
openalex   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines. [PDF]

, 1993
Because human lymphotoxin (LT) was originally isolated from a lymphoblastoid cell line, we investigated the role of this molecule in three newly established Epstein-Barr virus (EBV)-infected human B cell lines.
Aggarwal, BB, Estrov, Z, Harris, D, Kantarjian, HM, Kurzrock, R, Pathak, S, Pocsik, E, Talpaz, M, Zipf, TF   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Lignan compound isolated from n-Hexane extract myristica fragrans Houtt root as antioxidant and antitumor activities against MCF-7 cell lines data

, 2020
Binawati Ginting, Nurdin Saidi, MURNIANA MURNIANA, Mustanir Mustanir, Maulidna, Partomuan Simanjuntak   +5 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Lines of principal curvature on canal surfaces in R³

Anais da Academia Brasileira de Ciências, 2006
In this paper are determined the principal curvatures and principal curvature lines on canal surfaces which are the envelopes of families of spheres with variable radius and centers moving along a closed regular curve in R³.
Garcia Ronaldo, Llibre Jaume, Sotomayor Jorge   +2 more
doaj  

Two Diarylundecanones Isolated from

Natural Product Communications, 2017
Ardisinones G-H ( 1–2 ), two new diarylundecanones, were isolated from the ethanol extract of aerial parts of Ardisia tenera Mez. Their structures were elucidated by interpretation of the spectroscopic evidence.
Chong-Yu Lu, Hong-Xiang Li, Sha Li, Ling Qiu, Si Yu, Zhi-Xing Cao, Da-Le Guo, Yun Deng   +7 more
doaj   +1 more source