Results 101 to 110 of about 2,609,725 (348)

A New Paclitaxel Formulation Based on Secretome Isolated from Mesenchymal Stem Cells Shows a Significant Cytotoxic Effect on Osteosarcoma Cell Lines [PDF]

open access: gold, 2023
Alessia Giovanna Santa Banche Niclot   +11 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Triterpenoid of avocado (Persea americana) seed and its cytotoxic activity toward breast MCF-7 and liver HepG2 cancer cells

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2017
Objective: To determine the structure of triterpenoid isolated from avocado seeds and the cytotoxic effect on MCF-7 and HepG2 cells. Methods: The powder sample was macerated with ethanol, followed with separation of the extract by column chromatography ...
Andi Nur Fitriani Abubakar   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Generation of two induced pluripotent stem cell lines NCCSi005A and NCCSi006A from CD4+T cells of healthy individuals of Indian origin

open access: yesStem Cell Research, 2019
Human induced pluripotent stem cell-lines (iPSCs) of Indian origin NCCSi005A and NCCSi006A were established by reprogramming of CD4+T cells, isolated from the peripheral blood mononuclear cells (PBMCs) of two healthy female donors.
Mohsina Khan   +4 more
doaj   +1 more source

Unshifted Metastable He I* Mini-Broad Absorption Line System in the Narrow Line Type 1 Quasar SDSS J080248.18$+$551328.9

open access: yes, 2014
We report the identification of an unusual absorption line system in the quasar SDSS J080248.18$+$551328.9 and present a detailed study of the system, incorporating follow-up optical and NIR spectroscopy.
Ge, Jian   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

New Schiartane- Triterpene from and their Cytotoxic Activities

open access: yesNatural Product Communications, 2014
One new schiartane- type triterpene, heteroclitalactone N ( 1 ), and four known compounds ( 2–5 ), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita . Their structures were
Pham Thi Hong Minh   +10 more
doaj   +1 more source

A Hubble Space Telescope Snapshot Survey of Dynamically Close Galaxy Pairs in the CNOC2 Redshift Survey

open access: yes, 2005
We compare the structural properties of two classes of galaxies at intermediate redshift: those in dynamically close galaxy pairs, and those which are isolated. Both samples are selected from the CNOC2 Redshift Survey, and have redshifts in the range 0.1
C. J. Pritchet   +8 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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