Results 191 to 200 of about 2,609,725 (348)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Anticancer Potential of Piericidin A1 and Derivatives Isolated From Streptomyces sp. Associated With Palythoa variabilis From Brazilian Reefs. [PDF]

Chem Biodivers
Sahm BDB, Florêncio KGD, Pinto FCL, Maia AIV, Rocha CAM, Jimenez PC, Pessoa ODL, Lotufo TMC, Costa-Lotufo LV, Wilke DV.   +9 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Back to the future 2: the implications of germplasm structure on the balance between short- and long-term genetic gain in a changing target population of environments. [PDF]

G3 (Bethesda)
Technow F, Podlich D, Cooper M.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The inositol pyrophosphate 5-InsP₇ regulates mitochondrial polyphosphate synthesis and bioenergetic function. [PDF]

J Biol Chem
Ladke JS, Khan A, Singh A, Jessen HJ, Kolthur-Seetharam U, Jaiswal M, Bhandari R.   +6 more
europepmc   +1 more source

Virus-specific and autoreactive T cell lines isolated from cerebrospinal fluid of a patient with chronic rubella panencephalitis

, 1989
Roland Martinꝉ, P Marquardt, Siobhan O’Shea, Martin Borkenstein, Hans Wolfgang Kreth   +4 more
openalex   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Diels-Alder Adducts from <i>Maytenus chiapensis</i>. [PDF]

Int J Mol Sci
G Castillo U, Martínez ML, Núñez MJ, González-Bakker A, Padrón JM, Nocchi N, Hernández-Álvarez E, Jiménez IA, Bazzocchi IL.   +8 more
europepmc   +1 more source

Genomic Analysis of <I>Vibrio cholerae</I> Strains Isolated in Siberia and the Far East during the Seventh Cholera Pandemic: Determining the Appurtenance to Global Phylogenetic Lines

Л. В. Миронова, I. S. Fedotova, Yu. P. Galach’yants, А. С. Пономарева, S. V. Erdyneev, Zh. Yu. Khunkheeva, E. A. Basov, A. V. Fortunatova, С. В. Балахонов   +8 more
openalex   +2 more sources