β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Enterohemorrhagic Escherichia coli with particular attention to the German outbreak strain O104:H4 [PDF]
This review deals with the epidemiology and ecology of enterohemorrhagic Escherichia coli (EHEC), a subset of the verocytotoxigenic Escherichia coli (VTEC), and subsequently discusses its public health concern.
De Reu, K +4 more
core +1 more source
Diverse reductive dehalogenases are associated with Clostridiales-enriched microcosms dechlorinating 1,2-dichloroethane [PDF]
The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process.
Balloi, Annalisa +8 more
core +5 more sources
Microbiological characteristics of Streptococcus pneumoniae strains isolated in Yakutsk
The microbiological and molecular genetic characteristics of S. pneumoniae strains, identified during nasopharyngeal carriage, were determined in patients from the age of 6 months up to 85 years old, living in Yakutsk. The obtained data indicate the prevalence of virulent antibiotic-resistant S.
Ya.A. Akhremenko +7 more
openaire +1 more source
Isolation and characterization of bacteriophages of rumen bacterium Prevotella bryantii TC1-1
Sampling, inoculation and extraction procedures were elaborated for the isolation of bacteriophages from cattle rumen fluid. Several strains from four different species of rumen bacterial genus Prevotella were used as indicator organisms as well as ...
Darja FERME +4 more
doaj +1 more source
Isolation and identification of a cellulolytic Enterobacter from rumen of Aceh cattle
Aims: The aim of this study was to isolate and identify a cellulolytic bacterium from the rumen fluid of Aceh’s cattle. Biodegradation by cellulolytic rumen bacteria can be used as a source of cellulolytic bacteria that act to degrade feed fibrous ...
Wenny Novita Sari +3 more
semanticscholar +1 more source
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Plasmide DNA isolation from bacteria and transfection to HEK293 cell line [PDF]
Izolace plasmidové DNA je v mikrobiologii důležitou a často využívanou metodou. Samotné izolaci předchází příprava bakteriálních kompetentních buněk a amplifikace plasmidů. V této práci jsou plasmidy CHR2, ASAP1, ASAP-3, ASAP-5 a Kir2.1.
Měsíčková, Klára
core
Resuscitation and quantification of stressed Escherichia coli K12 NCTC8797 in water samples [PDF]
The aim of this study was to investigate the impact on numbers of using different media for the enumeration of Escherichia coli subjected to stress, and to evaluate the use of different resuscitation methods on bacterial numbers. E. coli was subjected to
Bissonnette +37 more
core +1 more source
Microbiological and Molecular Characterization of Staphylococcus hominis Isolates from Blood
Among Coagulase-Negative Staphylococci (CoNS), Staphylococcus hominis represents the third most common organism recoverable from the blood of immunocompromised patients. The aim of this study was to characterize biofilm formation, antibiotic resistance, define the SCCmec (Staphylococcal Chromosomal Cassette mec) type, and genetic relatedness of ...
Mendoza Olazarán, Soraya Sarahí +7 more
openaire +5 more sources

