Results 51 to 60 of about 197,005 (375)

Causal relationship between branched-chain amino acids and peripheral atherosclerosis： a Mendelian randomization study

Shanghai yufang yixue, 2023
ObjectiveWe conducted a two-sample Mendelian randomization （MR） study to assess the causal relationship between circulating isoleucine， leucine and valine levels and the risk of peripheral atherosclerosis.MethodsBased on the large-scale genome-wide ...
FU Yuanyuan, CHEN Jie, CAI Shiyuan, LI Xue   +3 more
doaj   +1 more source

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) co-produced with l-isoleucine in Corynebacterium glutamicum WM001

Microbial Cell Factories, 2018
BackgroundCo-production of polyhydroxyalkanoate (PHA) and amino acids makes bacteria effective microbial cell factories by secreting amino acids outside while accumulating PHA granules inside. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is one of
Wenjian Ma, Jianli Wang, Ye Li, L. Yin, Xiaoyuan Wang   +4 more
semanticscholar   +1 more source

Production of d-Branched-Chain Amino Acids by Lactic Acid Bacteria Carrying Homologs to Isoleucine 2-Epimerase of Lactobacillus buchneri

Frontiers in Microbiology, 2018
Isoleucine 2-epimerase (ILEP) is a novel branched-chain amino acid racemase isolated from Lactobacillus buchneri. In this study, we examined production of free d-branched-chain amino acids such as d-valine, d-leucine, and d-allo-isoleucine, using lactic ...
Y. Mutaguchi, K. Kasuga, Ikuo Kojima
semanticscholar   +1 more source

Determining the optimal digestible isoleucine to lysine ratio of Ross 708 × Ross YP male broilers from 14 to 28 days of age

Journal of Applied Poultry Research, 2021
SUMMARY: Previous research within our laboratory determined the optimal male Ross 708 dIle:dLys ratio for the starter phase to be greater than recent breeder recommendations (70 vs. 67%).
A.T. Brown, J.T. Lee, R. Adhikari, K. Haydon, K.G.S. Wamsley   +4 more
doaj  

Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs [PDF]

, 2013
Most archaea and bacteria use a modified C in the anticodon wobble position of isoleucine tRNA to base pair with A but not with G of the mRNA. This allows the tRNA to read the isoleucine codon AUA without also reading the methionine codon AUG.
Babu, I. Ramesh, Blum, Paul, Chan, Tsz Yan Clement, Dedon, Peter C., Koehrer, Caroline, Kuwahara, Masayasu, Liu, Yuchen, Mandal, Debabrata, Rajbhandary, Uttam L., Soll, Dieter, Su, Dan   +10 more
core   +1 more source

Determining the optimal digestible isoleucine to lysine ratio of Ross 708 × Ross YP male broilers from 28 to 42 days of age

Journal of Applied Poultry Research, 2021
SUMMARY: Recent research within our laboratory has determined the optimal Ross 708 × Ross YP male broiler dIle:dLys ratio for the starter and grower phases to be 70 and 68%, respectively.
A.T. Brown, J.T. Lee, R. Adhikari, K. Haydon, K.G.S. Wamsley   +4 more
doaj  

Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector

PLoS Genetics, 2018
Listeria monocytogenes (Lm) is a saprophyte and intracellular pathogen. Transition to the pathogenic state relies on sensing of host-derived metabolites, yet it remains unclear how these are recognized and how they mediate virulence gene regulation.
Moran Brenner, L. Lobel, I. Borovok, N. Sigal, Anat A. Herskovits   +4 more
semanticscholar   +1 more source

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

Application of Raman spectroscopy in type 2 diabetes screening in blood using leucine and isoleucine amino-acids as biomarkers and in comparative anti-diabetic drugs efficacy studies

PLoS ONE, 2017
Diabetes is an irreversible condition characterized by elevated blood glucose levels. Currently, there are no predictive biomarkers for this disease and the existing ones such as hemoglobin A1c and fasting blood glucose are used only when diabetes ...
Zephania Birech, P. Mwangi, F. Bukachi, K. Mandela   +3 more
semanticscholar   +1 more source

Egg production and quality responses to increasing isoleucine supplementation in Shaver white hens fed a low crude protein corn-soybean meal diet fortified with synthetic amino acids between 20 and 46 weeks of age

Poultry Science, 2020
The present study evaluated production performance responses to Ile supplementation in laying hens fed low crude protein (LCP), amino acid (AA) balanced diets.
Ilona A. Parenteau, Marvin Stevenson, Elijah G. Kiarie   +2 more
doaj