Results 71 to 80 of about 105,135 (263)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

l-Isoleucine Administration Alleviates Rotavirus Infection and Immune Response in the Weaned Piglet Model

Frontiers in Immunology, 2018
Rotavirus (RV) infection is one of the main pathogenic causes of severe gastroenteritis and diarrhea in infants and young animals. This study aimed to determine how dietary l-isoleucine supplementation improves the growth performance and immune response ...
Xiangbing Mao, Xiangbing Mao, Changsong Gu, Changsong Gu, Man Ren, Daiwen Chen, Daiwen Chen, Bing Yu, Bing Yu, Jun He, Jun He, Jie Yu, Jie Yu, Ping Zheng, Ping Zheng, Junqiu Luo, Junqiu Luo, Yuheng Luo, Yuheng Luo, Jianping Wang, Jianping Wang, Gang Tian, Gang Tian, Qing Yang   +23 more
doaj   +1 more source

Improving the Physicochemical Properties, Organic Acids, Amino Acids, Volatile Organic Compounds, and Metabolites of Laohan Melon Juice Through Fermentation With Different Lactic Acid Bacteria

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Fermentation with lactic acid bacteria could improve amino acids, volatile organic compounds (VOCs), and nonvolatile metabolites of Laohan melon juice (LMJ), which provides theoretical guidance for the development of Laohan melon beverage and advances knowledge of the metabolic mechanisms of VOCs in LMJ.
Yun Xie, Sihan Hou, Mingdong Tan, Jianqiao Jiang, Yue Hu, Yiwen Chen, Yongkang Li, Miao Cui, Jianming Niu, Weidong Cheng, Xilei Pu, Yuyun He, Feifei Gao   +12 more
wiley   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

DETERMINATION OF CONSECUTIVE REACTION RATE CONSTANTS BETWEEN GLYCINE AND ISOLEUCINE WITH o-PHTHALDIALDEHYDE AND 2-MERCAPTOETHANOL FROM SINGLE EXPERIMENT DATA

Indonesian Journal of Chemistry, 2011
Kinetics study of chemical reaction is important in producing optimum product, designing a reactor, analyzing a compound, and many other purposes. This work presents the result of study of consecutive pseudo first order reaction between glycine and ...
Iip Izul Falah, Triyono Triyono, Catur Atmaji   +2 more
doaj   +1 more source

Bimetallic Ruthenium‐Cobalt Catalyst Supported on Carbon Nanotubes: Synthesis, Characterization, and Application in Electrochemical Sensing of Isoleucine

Advanced Materials Interfaces
In this work, a bimetallic Ru‐Co catalyst based on carbon nanotubes (Ru‐Co/CNT) with a Ru to Co ratio of 95:5 is developed. The catalyst, featuring a total metal loading of 3% on the CNTs, is synthesized using the NaBH4 reduction method.
Omrüye Ozok Arıcı, Aykut Caglar, Bassam A. Najri, Nahit Aktaş, Arif Kivrak, Hilal Kivrak   +5 more
doaj   +1 more source

Exogenous isoleucine and phenylalanine interact with abscisic acid-mediated anthocyanin accumulation in grape

Folia Horticulturae, 2019
Berry skin colour is a crucial determinant of red/black grape berry quality. We investigated the effects of combination treatments with amino acids and a low concentration of ABA on anthocyanin accumulation in grapes.
Hattori Tomoki, Chen Yang, Enoki Shinichi, Igarashi Daisuke, Suzuki Shunji   +4 more
doaj   +1 more source

A " NEW " DISORDER OF ISOLEUCINE CATABOLISM

The Lancet, 1971
A disorder of isoleucine catabolism was found in a child with intermittent metabolic acidosis. The block occurs at the stage of propionate synthesis, and two intermediates--alpha-methylacetoacetate and alpha-methyl-beta-hydroxybutyrate--accumulate. The condition is apparently inherited.
R S, Daum, P H, Lamm, O A, Mamer, C R, Scriver   +3 more
openaire   +3 more sources

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source