Results 81 to 90 of about 180,552 (305)
Advanced Science, EarlyView.This study reveals the mechanism by which jasmonic acid (JA) regulates lycopene synthesis under light and dark conditions. In light, JA activates SlMYC2, which suppresses SlPIF1a and promotes SlPSY1 expression. In darkness, JA induces the acetyltransferase SlNATA1, which acetylates the dark‐accumulated SlPIF1a, thereby repressing SlPSY1 expression ...
Jiayi Xu +10 more
wiley +1 more source
Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. [PDF]
, 2013 In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD).
Bogdanov, MB +11 more
core +2 more sources
Advanced Science, EarlyView.Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija +22 more
wiley +1 more source
Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]
, 1999 In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Hammer, C. +7 more
core +1 more source
N-Acetyl-isoleucine in Streptomyces avermitilis [PDF]
FEMS Microbiology Letters, 1992 N-Acetyl-isoleucine was identified during growth of Streptomyces avermitilis in a chemically defined medium supplemented with isoleucine.
J, Nĕmecek, J, Novák, J, Kopecký
openaire +2 more sources
Halofuginone is a Molecular Glue Degrader of Integrin β4
Advanced Science, EarlyView.Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation
Clinical Case Reports, 2018 Key Clinical Message Methylmalonic aciduria children must follow an adequate diet with low protein intake and should be regularly monitored to prevent complications.
Joana Rosa +5 more
doaj +1 more source
Methylmalonic Aciduria in Children: Clinical Recommendations
Педиатрическая фармакология, 2017 Methylmalonic acidemia (aciduria) is an inherited metabolic disturbance from the group of organic acidemias (acidurias). The article presents etiopathogenetic, epidemiological, diagnostic, and therapeutic aspects of the problem.
Alexander A. Baranov +16 more
doaj +1 more source
Metabolic properties of the products of mitochondrial protein synthesis in HeLa cells [PDF]
, 1977 The metabolic behavior of the mitochondrial protein synthesis products has been investigated in HeLa cells. Particular attention was given to the four major electrophoretic components (designated as Nos. 2, 3, 5, and 8) of the 10 previously identified as
Attardi, Giuseppe, Costantino, Paolo
core
Nippon kagaku zassi, 1957 イソロイシンは従来他の脂肪属アミノ酸と同様な方法で合成されているが,著者らは実用的な目的を以て最近安価に入手し得るメチルエチルケトンからイソロィシンを合成することを二方法,すなわち中間体としてα一ニトローβ 一メチルーβ 一エチルアクリル酸エチルを経る方法と,α 一プロムーβ一メチルバレリアン酸を経る方法とによって試み,かつ得られたイソロイシンについて,イソロイシンとアロイソロィシンの混合比を関の方法により定量した。
Yutaka Mori +2 more
openaire +2 more sources