Results 81 to 90 of about 102,137 (247)
Angewandte Chemie International Edition, EarlyView.The pyrrolysyl‐tRNA synthetase dimer exhibits an alternating mode of action of its monomers within its catalytic cycle, which is realized upon occupation of secondary binding sites located at the intermonomer interfaces outside the catalytic binding site.
Jessica Dröden +6 more
wiley +1 more source
Frontiers in EndocrinologyObjectiveTo investigate the relationship between circulating branched-chain amino acids (BCAAs) and the risk of major adverse cardiovascular events (MACE) in a national population-based cohort study.MethodsUK Biobank, a prospective study involving 22 ...
Wanwan Sun +5 more
doaj +1 more source
Journal of the agricultural chemical society of Japan, 1962 不飽和カルボン酸に対するグリニヤール試薬の1, 4付加反応をイソロイシンの合成に応用し,新合成法を確立した.すなわち,クロトン酸およびそのsec-ブチルエステルにエチルマグネシウムブロミドを作用せしめた後,その反応コンプレックスにハロゲンを付加し,得られたα-ハロゲンカルボン酸をアミノ化してイソロイシンを合成した.なお,この際グリニヤールコンプレックスへのヨウ素付加においてスレオ型が優先して生ずることより,その付加が隣接基の立体効果をうける現象を認めた.
openaire +2 more sources
Crystal structure of a new polymorph of (2S,3S)-2-amino-3-methylpentanoic acid
Acta Crystallographica Section E: Crystallographic Communications, 2018 A new polymorph of (2S,3S)-2-amino-3-methylpentanoic acid, l-isoleucine C6H13NO2, crystallizes in the monoclinic space group P21 with four independent molecules in the asymmetric unit. The molecules are zwitterions. In the crystal, N—H...O hydrogen bonds
Sofia Curland +2 more
doaj +1 more source
Animal Research and One Health, EarlyView.Palatability enhancers modulate taste and smell, increasing feed acceptance, reducing weaning stress, and improving piglet performance. ABSTRACT The continuous growth of global agribusiness stimulates the search for alternatives that can enhance the performance and quality of life of production animals.
Luana Specht +3 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Osteoarthritis—the leading cause of disability worldwide—disproportionately affects females, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven +6 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Background Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source
Bioprospecting Ulleungdo‐isolated microalgae for carbon valorization and utilization
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract The growing demand for renewable energy alternatives has intensified global interest in microalgae as versatile bioresources for carbon valorization and bioenergy production. Owing to their rapid growth and biochemical versatility, microalgae provide a sustainable route for converting captured carbon into bioenergy and high‐value products ...
Ha‐Neul Choi +5 more
wiley +1 more source
GLP‐1 agonists and the gut microbiome: A bidirectional relationship
British Journal of Clinical Pharmacology, EarlyView.Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath +2 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius +6 more
wiley +1 more source