Results 111 to 120 of about 527 (157)

Potent kinase inhibitors from the Merck KGaA OGHL: Novel hits against Trypanosoma brucei with potential for repurposing. [PDF]

PLoS Negl Trop Dis
Dize D, Moumbock AFA, Tchuenguia VC, Bougnogolo GY, Nana FSB, Monkam SDW, Boyom FF.   +6 more
europepmc   +1 more source

Cure of experimental Trypanosoma vivax infection with a single dose of an unmodified antibody-based drug targeting the invariant flagellum cell surface protein IFX

Autheman D, Viola C, Rhodes G, Clare S, Brandt C, Harcourt K, Wright GJ.   +6 more
europepmc   +1 more source

[Prothidium and isometamidium as drugs against Trypanosomia brucei in dogs].

Revue d'elevage et de medecine veterinaire des pays tropicaux, 1971
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Monitoring the correct use of isometamidium by farmers and veterinary assistants in Eastern Province of Zambia using the isometamidium-ELISA

Veterinary Parasitology, 2002
A survey to monitor the use of trypanocidal drugs by cattle breeders was conducted in Zambia. Use was made of a questionnaire and of the isometamidium-ELISA technique. One hundred and twenty-two farmers and 50 veterinary assistants were interviewed. The isometamidium-ELISA was used to monitor the isometamidium serum concentration in 72 cattle, 1 week ...
Mark Eisler, M C Eisler, V Delespaux
exaly   +4 more sources

Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense

International Journal for Parasitology, 2005
Isometamidium chloride has remained a very important prophylactic and therapeutic drug against trypanosomosis in cattle since its introduction into the market in the 1950s with, unfortunately, a concomitant development of resistance in trypanosomosis endemic areas. Amplified Fragment Length Polymorphism (AFLP) was used to compare two isogenic clones of
Phelix Majiwa, V Delespaux, D Geysen
exaly   +4 more sources

Development of a radioimmunoassay for isometamidium

Veterinary Research Communications, 1988
A radioimmunoassay for the trypanocidal drug isometamidium (ISMM) has been developed using antibodies produced in sheep immunized against the drug cross-linked to human serum albumin. With 14C-ISMM as a radioligand, cross-reactivity of the antibodies was determined and found to be less than 3% with pyrithidium, diminazene and quinapyramine and about 13%
L D, Kinabo, J A, Bogan
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Effect of isometamidium on Trypanosoma congolense infectivity

Veterinary Parasitology, 1991
Isometamidium chloride (Samorin, RMB, England) is a widely used and highly effective trypanocide for the treatment of bovine trypanosomiases. However, the appearance of isometamidium-resistant populations of T. congolense in Africa makes it necessary to develop methods for the rapid and reliable detection of drug resistance in the laboratory. Currently
I A, Sutherland, A, Mounsey, P H, Holmes
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Pharmacokinetic and histopathological investigations of isometamidium in cattle

Research in Veterinary Science, 1988
The absorption and distribution patterns of the trypanocidal drug isometamidium and its effect on tissues in cattle were characterised. After intramuscular administration of a prophylactic dose of 0.5 mg kg-1 bodyweight, the drug was rapidly detectable in serum at a mean maximum concentration of only 20 ng ml-1 and declined to concentrations of lower ...
L D, Kinabo, J A, Bogan
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Acute toxicity of samorin (Isometamidium chloride) in rabbits

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1984
Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death.
B H, Ali, E M, Haroun
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Preliminary pharmacokinetic study of isometamidium chloride in camels

Research in Veterinary Science, 1984
Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg ...
B H, Ali, T, Hassan
openaire   +2 more sources