Results 1 to 10 of about 455 (119)

Genomic analysis of Isometamidium Chloride resistance in Trypanosoma congolense [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Isometamidium Chloride (ISM) is one of the principal drugs used to counteract Trypanosoma congolense infection in livestock, both as a prophylactic as well as a curative treatment. However, numerous cases of ISM resistance have been reported in different
Hideo Imamura, Jan Van Den Abbeele, Jean-Claude Dujardin   +2 more
exaly   +8 more sources

Nanoformulation of a Trypanocidal Drug Isometamidium Chloride Ameliorates the Apurinic-Apyrimidinic DNA Sites/Genotoxic Effects in Horse Blood Cells [PDF]

Journal of Xenobiotics, 2023
Isometamidium chloride (ISM) is a trypanocide for the prophylactic and therapeutic use against vector-borne animal trypanosomosis (mainly Surra caused by Trypanosoma evansi) and African animal trypanosomosis caused by T. congolense/T. vivax/T.
Minakshi Prasad, Neeraj Dilbaghi, Anju Manuja   +2 more
exaly   +4 more sources

Isometamidium chloride and homidium chloride fail to cure mice infected with Ethiopian Trypanosoma evansi type A and B. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Trypanosoma evansi is mechanically transmitted by biting flies and affects camels, equines, and other domestic and wild animals in which it causes a disease called surra.
Gebrekrustos Mekonnen, Elmi Fahiye Mohammed, Weldu Kidane, Awol Nesibu, Hagos Yohannes, Nick Van Reet, Philippe Büscher, Hadush Birhanu   +7 more
doaj   +5 more sources

Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever.
Vincent Delespaux, Hervé Sèna Vitouley, Tanguy Marcotty, Niko Speybroeck, Dirk Berkvens, Krisna Roy, Stanny Geerts, Peter Van den Bossche   +7 more
doaj   +7 more sources

Comparative experimental studies on Trypanosoma isolates in mice and response to diminazene aceturate and isometamidium chloride treatment [PDF]

Heliyon, 2018
The current study was undertaken from December 2015 to May 2016 with the aim of determining and comparing the pathogenicity and response to diminazene aceturate (DA) and isometamidium chloride (ISM) treatment in experimentally infected mice with ...
Muluken Yayeh, Shimelis Dagnachew, Meseret Tilahun, Achenef Melaku, Tadegegn Mitiku, Mohamed Yesuf, Zewdu Seyoum, Habtamu Kefyalew   +7 more
doaj   +5 more sources

Efficacy of diminazene diaceturate and isometamidium chloride hydrochloride for the treatment of Trypanosoma evansi in mice model. [PDF]

J Parasit Dis, 2021
Diminazene diaceturate (DIM) and isometamidium chloride hydrochloride (ISMM) have been widely used for the treatment of animal trypanosomosis. We evaluated the efficacy of standard doses of DIM and ISMM followed by their double doses for the treatment of Trypanosoma evansi in experimentally infected mice. A T.
Aregawi WG, Gutema F, Tesfaye J, Sorsa A, Megersa B, Teshome P, Agga GE, Ashenafi H.   +7 more
europepmc   +4 more sources

Variation of sensitivity of Trypanosoma evansi isolates from Isiolo and Marsabit counties of Kenya to locally available trypanocidal drugs. [PDF]

PLoS ONE, 2023
Trypanocidal resistance is a major cause of treatment failure. This study evaluated the sensitivity of Trypanosoma evansi field isolates collected from Marsabit and Isiolo counties, Kenya. A total of 2,750 camels were screened using parasitological tests
Raymond E Mdachi, Kennedy O Ogolla, Joanna E Auma, Florence N Wamwiri, Richard K Kurgat, Kennedy B Wanjala, Lawrence G Mugunieri, Phylis M Alusi, Judith K Chemuliti, Phoebe W Mukiria, Sylvance O Okoth   +10 more
doaj   +2 more sources

Trypanocide usage in the cattle belt of southwestern Uganda [PDF]

Frontiers in Microbiology, 2023
BackgroundSystematic infrastructure and regulatory weaknesses over many decades, in communities struggling with animal African trypanosomiasis (AAT) would be expected to create an environment that would promote drug misuse and risk development of drug ...
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Ewan Thomas MacLeod, Keith Robert Sones, Keith Robert Sones, Susan Christina Welburn, Susan Christina Welburn   +6 more
doaj   +2 more sources

An evaluation of African animal trypanosomiasis control strategies in remote communities of Eastern Zambia [PDF]

Parasitology
Communities living in African animal trypanosomiasis (AAT) endemic areas of Zambia use several control strategies to protect their livestock from the devastating effects of trypanosomiasis.
Gloria M. Mulenga, Kalinga Chilongo, Chrisborn Mubamba, Bruce Gummow   +3 more
doaj   +2 more sources

Drug quality analysis of isometamidium chloride hydrochloride and diminazene diaceturate used for the treatment of African animal trypanosomosis in West Africa [PDF]

BMC Veterinary Research, 2018
Background Diminazene diaceturate (DA) and isometamidium chloride hydrochloride (ISM) are with homidium bromide, the main molecules used to treat African Animal Trypanosomosis (AAT).
Zakaria Bengaly, Sèna Hervé Vitouley, Martin Bienvenu Somda, André Zongo, Assiongbon Têko-Agbo, Giuliano Cecchi, Yahaya Adam, Issa Sidibé, Balé Bayala, Adrien Marie Gaston Belem, Jan Van Den Abbeele, Vincent Delespaux   +11 more
doaj   +2 more sources