Results 201 to 210 of about 1,705 (235)

Acute toxicity of samorin (Isometamidium chloride) in rabbits

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1984
Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death.
B H, Ali, E M, Haroun
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Preliminary pharmacokinetic study of isometamidium chloride in camels

Research in Veterinary Science, 1984
Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg ...
B H, Ali, T, Hassan
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The appearance of isometamidium resistant "Trypanosoma congolense" in West Africa

Acta tropica, 1984
The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium prophylaxis in the Upper Volta indicated that drug-resistant forms might be appearing. To investigate this possibility, trypanosome stocks were isolated in mice, their isometamidium sensitivity estimated and compared to that of ...
M, Pinder, E, Authie
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The Toxic Effect of Intravenous Application of the Trypanocide Isometamidium (Samorin®)

Zentralblatt für Veterinärmedizin Reihe A, 1985
SummaryFor the trypanocide isometamidium chloride (Samorin®, May & Baker) the intramuscular route is recommended by the suppliers but application by this route is followed by local tissue irritation and necrosis. The intravenous administration leads to a dose‐dependent acute systemic toxicity, which can be fatal.
D, Schillinger, S H, Maloo, D, Röttcher
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Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride

Parasitology Research, 1997
Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the drug.
Kaminsky R, Schmid C, Lun ZR
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A Simple Competitive Enzyme Immunoassay for the Detection of the Trypanocidal Drug Isometamidium

Therapeutic Drug Monitoring, 1996
A new competitive enzyme immunoassay technique has been developed for the determination of concentrations of the trypanocidal drug isometamidium chloride (Samorin) in bovine serum. The method has been shown to be highly repeatable and reproducible, and it has several advantages over previous immunoassay techniques for the drug.
Eisler, MC, Elliott, CT, Holmes, PH
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Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions

Research in Veterinary Science, 1991
The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed within 15 to 30 minutes to reach maximum plasma concentrations of 12 to 477 (n = 6), 302 to 655 (n = 4) and 1620 (n = 1) ng ml-1 ...
L D, Kinabo, Q A, McKellar, P D, Eckersall   +2 more
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Isometamidium in goats: Disposition kinetics, mammary excretion and tissue residues

British Veterinary Journal, 1990
The pharmacokinetics of the antitrypanosomal drug isometamidium were studied in lactating goats after intravenous and intramuscular administration at a dose of 0.5 mg/kg body weight, in a crossover design at an interval of 6 weeks. Following intravenous administration, the half-life of the disappearance of the drug from plasma during the terminal phase
L D, Kinabo, Q A, McKellar
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Influence of atropine on the acute toxicity of isometamidium.

Veterinary and human toxicology, 1993
The effectiveness of atropine in blocking the acute toxic effects of the antitrypanosomal drug isometamidium (ISMM) was evaluated in mice and goats using lethality as the primary index. The median lethal dose (LD50) of ISMM in nonatropinized mice was 45.3 mg/kg bodyweight (SE +/- 5.3 mg/kg bodyweight), whereas the LD50 of ISMM in mice pre-treated with ...
A A, Gimbi, L D, Kinabo
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Metabolism of isometamidium in hepatocytes isolated from control and inducer‐treated rats

Journal of Veterinary Pharmacology and Therapeutics, 2006
Little is known about the metabolism and mechanism of action of the trypanocide, isometamidium (ISM), the major drug used for prophylaxis of trypanosomiasis. We have investigated its metabolism and distribution in isolated rat hepatocytes using liquid chromatography‐mass spectrometry and confocal laser scanning microscopy (CLSM).
I, Boibessot, J N A, Tettey, G G, Skellern, D G, Watson, M H, Grant   +4 more
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