Results 1 to 10 of about 1,075 (155)

Genomic analysis of Isometamidium Chloride resistance in Trypanosoma congolense. [PDF]

Int J Parasitol Drugs Drug Resist, 2017
Isometamidium Chloride (ISM) is one of the principal drugs used to counteract Trypanosoma congolense infection in livestock, both as a prophylactic as well as a curative treatment. However, numerous cases of ISM resistance have been reported in different African regions, representing a significant constraint in the battle against Animal African ...
Tihon E, Imamura H, Van den Broeck F, Vermeiren L, Dujardin JC, Van Den Abbeele J.   +5 more
europepmc   +6 more sources

Efficacy of diminazene diaceturate and isometamidium chloride hydrochloride for the treatment of Trypanosoma evansi in mice model. [PDF]

J Parasit Dis, 2021
Diminazene diaceturate (DIM) and isometamidium chloride hydrochloride (ISMM) have been widely used for the treatment of animal trypanosomosis. We evaluated the efficacy of standard doses of DIM and ISMM followed by their double doses for the treatment of Trypanosoma evansi in experimentally infected mice. A T.
Aregawi WG, Gutema F, Tesfaye J, Sorsa A, Megersa B, Teshome P, Agga GE, Ashenafi H.   +7 more
europepmc   +4 more sources

Isometamidium chloride and homidium chloride fail to cure mice infected with Ethiopian Trypanosoma evansi type A and B. [PDF]

PLoS Negl Trop Dis, 2018
Trypanosoma evansi is mechanically transmitted by biting flies and affects camels, equines, and other domestic and wild animals in which it causes a disease called surra. At least two types of Trypanosoma evansi circulate in Ethiopia: type A, which is present in Africa, Latin America and Asia, and type B, which is prevalent in Eastern Africa. Currently,
Mekonnen G, Mohammed EF, Kidane W, Nesibu A, Yohannes H, Van Reet N, Büscher P, Birhanu H.   +7 more
europepmc   +5 more sources

Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin. [PDF]

PLoS Negl Trop Dis, 2010
Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever. The existing compounds have become virtually useless and pharmaceutical companies are not keen on investing in the development of new trypanocides.
Delespaux V, Vitouley HS, Marcotty T, Speybroeck N, Berkvens D, Roy K, Geerts S, Van den Bossche P.   +7 more
europepmc   +8 more sources

Comparative experimental studies on Trypanosoma isolates in mice and response to diminazene aceturate and isometamidium chloride treatment. [PDF]

Heliyon, 2018
The current study was undertaken from December 2015 to May 2016 with the aim of determining and comparing the pathogenicity and response to diminazene aceturate (DA) and isometamidium chloride (ISM) treatment in experimentally infected mice with trypanosome isolates from Jawi and Birsheleko areas of northwest Ethiopia.
Yayeh M, Dagnachew S, Tilahun M, Melaku A, Mitiku T, Yesuf M, Seyoum Z, Kefyalew H.   +7 more
europepmc   +5 more sources

Influence of nutrition on trypanosome isometamidium chloride chemoprophylaxis [PDF]

Animal Research International, 2012
Thirty six weaner wistar rats were used to study the effect of protein nutrition on trypanosome isometamidium chloride prophylaxis. Two groups of rats A and B (n = 18 per group) were maintained on 21% and 14.5% crude protein diet respectively for the ...
Nnadi, PA, Onyeyili, PA
core   +4 more sources

Outbreak of <i>Trypanosoma vivax</i> in Dairy Cows: Hematologic, Immunological and Antioxidant Responses Before and After Treatment with Isometamidium Chloride. [PDF]

Pathogens
Trypanosoma vivax infection is an emerging condition that causes damage and mortality among cattle and is transmitted by mechanical vectors or contaminated fomites. This disease has been spreading in southern Brazil, causing anemia, weight loss, diarrhea, abortion, and infertility; however, its behavior and host–parasite relationships are not yet fully
Fritzen A, de Vitt MG, Deolindo GL, Signor MH, Correa NG, Ribeiro BG, Marques J, das Neves GB, Miletti LC, da Silva AS.   +9 more
europepmc   +4 more sources

The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence. [PDF]

Biochem J, 1995
Interaction of the trypanocide isometamidium chloride with components of Trypanosoma congolense results in characteristic shifts in the intrinsic fluorescence of the drug. The specificity of this interaction was investigated by analysing the effects of various physicochemical manipulations on its fluorescence properties.
Wilkes JM, Peregrine AS, Zilberstein D.
europepmc   +4 more sources

Follow-up of dairy cattle naturally infected by Trypanosoma vivax after treatment with isometamidium chloride [PDF]

Revista Brasileira de Parasitologia Veterinária, 2021
Abstract Trypanosoma vivax infections cause nonspecific clinical signs in cattle associated with aparasitemic intervals, making disease diagnosis a challenge. In Brazil, diminazene aceturate and isometamidium chloride (ISM) are available to treat bovine trypanosomosis.
Kayo José Garcia de Almeida Castilho Neto, Ana Beatriz da Cruz Favaro Garcia, Otavio Luiz Fidelis Junior, Walter Beterquini Nagata, Marcos Rogério André, Marta Maria Geraldes Teixeira, Rosangela Zacarias Machado, Fabiano Antonio Cadioli   +7 more
openaire   +7 more sources

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source