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Assessment of sensitivity of "Trypanosoma congolense" to isometamidium chloride : a comparison of tests using cattle and mice

Acta tropica, 1988
The sensitivities of 3 strains of Trypanosoma congolense to isometamidium chloride (Samorin) were determined in mice and cattle, with the objective of evaluating sensitivity testing in mice as a means of predicting curative doses in cattle. Comparison of mouse effective dose 80% (ED80) or curative dose 80% (CD80) values with cattle minimum curative ...
K R, Sones, A R, Njogu, P H, Holmes
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THE IN VITRO EFFECTS OF ISOMETAMIDIUM CHLORIDE (SAMORIN) ON THE PISCINE HEMOFLAGELLATECRYPTOBIA SALMOSITICA(KINETOPLASTIDA, BODONINA)

Journal of Parasitology, 2001
Isometamidium chloride (Samorin) is therapeutic in rainbow trout (Oncorhynchus mykiss) during preclinical and chronic cryptobiosis. However, the toxic mechanism of isometamidium on Cryptobia salmositica has not been elucidated. The objective of the present study was to examine the in vitro effects of isometamidium on C. salmositica.
B F, Ardelli, P T, Woo
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The effect of isometamidium chloride onTrypanosoma vivax occurring within the insect vector (Glossina)

Zeitschrift f�r Parasitenkunde Parasitology Research, 1984
The effect of chemoprophylaxis on developing and mature Trypanosoma vivax in Glossina tachinoides and G. palpalis palpalis was evaluated. Newly emerged G. tachinoides and G.p. palpalis flies were infected with T. vivax by allowing them to feed on parasitaemic animals.
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Some observations on the toxicosis of isometamidium chloride (samorin) in camels.

Veterinary and human toxicology, 1986
Healthy camels were experimentally infected with Trypanosoma evansi and then treated with isometamidium chloride (samorin) at single intravenous doses of 0.5 or 1.0 mg/kg. Five to 10 min after the drug administration, the camels at both dosages showed lacrimation, salivation, trembling, restlessness, frequent urination and defecation, followed by ...
B H, Ali, T, Hassan
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Development of an enzyme-linked immunosorbent assay for the detection and measurement of the trypanocidal drug isometamidium chloride in cattle

Research in Veterinary Science, 1991
An enzyme-linked immunosorbent assay (ELISA) was developed to measure accurately levels of the trypanocidal drug isometamidium in the serum of treated cattle. The assay requires only 5 microliters of test serum, is sensitive to a level of 0.5 pg ml-1 and is highly specific.
D D, Whitelaw   +6 more
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Susceptibility of a Trypanosoma congolense Isolate of Water-Buffalo Origin to Diminazene Aceturate and Isometamidium Chloride

International Journal of Tropical Insect Science, 1988
Laboratory mice infected with a Trypanosoma congolense isolate of water-buffalo origin did not respond when treated with diminazene aceturate (Berenil, Hoechst, West Germany) at 3.5 mg/kg and 7 mg/kg body weight (b.wt.) and also isometamidium chloride (Samorin, May & Baker, Dagenham, England) at doses less than 3 mg/kg b.wt. Effective cure was achieved
B. C. Njau, P. A. Mkonyi, K. Lekaki
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Field studies on animal trypanosomiasis in Mozambique. I. Effectiveness of the prophylactic drugs isometamidium chloride and pyrithidium bromide

Tropical Animal Health and Production, 1988
The efficacy of the trypanocides Samorin and Prothidium to protect beef cattle in areas of different trypanosome challenge was studied in Muabsa, Mozambique during an 18 month period. The performance of two groups of 1.5- to 3-year old bulls was observed, the first group in an area of high tsetse density, the second in an area of low to medium tsetse ...
W, Takken   +2 more
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Study of the genetic diversity of Trypanosoma congolense and its resistance to the drug Isometamidium Chloride

2017
Trypanosoma congolense is one of the major pathogens responsible for animal African Trypanosomiasis (AAT), a disease affecting about 10 million km2 of the sub-Saharan region on the African continent and considered as one of the principal causes of hunger and poverty in this region. Isometamidium Chloride (ISM) is the principal drug used to counteract T.
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