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Drug Metabolism and Disposition, 1996 Pharmacokinetics of the prophylactic and therapeutic trypanocidal drug isometamidium chloride were examined comprehensively for the first time in cattle using a recently described, highly sensitive ELISA. Cattle were administered single intravenous (N = 4) or intramuscular (N = 5) doses of isometamidium at a rate of 1.0 mg x kg(-1) body weight ...
Eisler, MC
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Preliminary pharmacokinetic study of isometamidium chloride in camels
Research in Veterinary Science, 1984Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg ...
B H, Ali, T, Hassan
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Acute toxicity of samorin (Isometamidium chloride) in rabbits
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1984Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death.
B H, Ali, E M, Haroun
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Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride
Parasitology Research, 1997Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the drug.
Kaminsky R, Schmid C, Lun ZR
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Veterinary Parasitology, 2007
Chromosome profiles of 10 Trypanosoma (T.) congolense populations with different isometamidium sensitivities were compared using the pulsed field gel electrophoresis technique. The aim was to elucidate whether there was a karyotype pattern specific to eight isometamidium resistant phenotypes.
Francis, Shahada +4 more
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Chromosome profiles of 10 Trypanosoma (T.) congolense populations with different isometamidium sensitivities were compared using the pulsed field gel electrophoresis technique. The aim was to elucidate whether there was a karyotype pattern specific to eight isometamidium resistant phenotypes.
Francis, Shahada +4 more
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Veterinary Parasitology, 2006
In large parts of Africa the control of livestock trypanosomiasis relies on the use of trypanocidal drugs. Resistance against the available compounds is developing rapidly in the trypanosome population. The effect of the development of drug resistance on the fitness of the trypanosome is not well known.
Van den Bossche, P. +3 more
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In large parts of Africa the control of livestock trypanosomiasis relies on the use of trypanocidal drugs. Resistance against the available compounds is developing rapidly in the trypanosome population. The effect of the development of drug resistance on the fitness of the trypanosome is not well known.
Van den Bossche, P. +3 more
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Action of isometamidium chloride on the insect vector form of Trypanosoma vivax
Research in Veterinary Science, 1985The effect of isometamidium chloride upon developing and mature Trypanosoma vivax occurring in Glossina palpalis palpalis flies was evaluated. Newly emerged G p palpalis flies were infected with T vivax by allowing them to feed on parasitaemic animals. Two experiments were conducted and in each the flies were divided into two groups.
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Pharmacokinetics and efficacy of isometamidium chloride against Trypanosoma vivax in cattle
Parasitology InternationalWe evaluated the pharmacokinetics (pk), preventive efficacy (PE) and therapeutic efficacy (TE) of isometamidium chloride (ISM) against T. vivax. For the pk study, the animals received ISM 1 mg/kg (1 mL/40 kg) on day 0 and plasma samples were collected at day 0 (immediately before treatment), 1 h, 3 h 6 h, 9 h and 12 h after treatment, D + 1 (24 h and ...
Luiz Fellipe Monteiro, Couto +10 more
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Medical and Veterinary Entomology, 2008 African animal trypanosomosis is a major pathological constraint to cattle breeding across 10 million km2 of sub-Saharan West African countries infested by tsetse flies, their cyclic vectors.
Jérémy Bouyer
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Veterinary Parasitology, 1988
Twenty dogs of mixed local East African breeds were used. Five of the dogs were uninfected controls and 15 were infected with T. brucei (ILRAD 273). Five of the infected dogs were untreated controls, five were treated with a high curative dose of diminazene aceturate, (7 mg kg-1 body weight (wt.), and five were given a subcurative dose of isometamidium
Kaggwa, E, Munyua, W K, Mugera, G M
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Twenty dogs of mixed local East African breeds were used. Five of the dogs were uninfected controls and 15 were infected with T. brucei (ILRAD 273). Five of the infected dogs were untreated controls, five were treated with a high curative dose of diminazene aceturate, (7 mg kg-1 body weight (wt.), and five were given a subcurative dose of isometamidium
Kaggwa, E, Munyua, W K, Mugera, G M
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