Results 11 to 20 of about 97,287 (310)

Protective effects of salep against isoniazid liver toxicity in wistar rats

Journal of Traditional and Complementary Medicine, 2018
Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis.
Hossein Kargar Jahromi, Morteza Pourahmad, Hassan Ali Abedi, Mohadeseh karimi, Zahra Kargar Jahromi   +4 more
doaj   +1 more source

Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study

Frontiers in Pharmacology, 2020
BackgroundThe potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide.
Isaac Zentner, Hyun-moon Back, Leonid Kagan, Selvakumar Subbian, Jyothi Nagajyothi, Shashikant Srivastava, Jotam Pasipanodya, Tawanda Gumbo, Gregory P. Bisson, Christopher Vinnard   +9 more
doaj   +1 more source

Uji Kepekaan Mycobacterium sp. terhadap Isoniazid (INH) Menggunakan Metode Rasio Resistensi secara In Vitro

Mutiara Medika, 2013
Infeksi mikobakteria termasuk diantara infeksi yang paling sulit disembuhkan dari semua jenis infeksi bakteri. Mikobakteria yang patogen utamanya adalah Mycobacterium tuberculosis sebagai penyebab tuberkulosis (TB), yang mengakibatkan lebih banyak ...
Dwi Yuni Nur Hidayati, Roekistiningsih Roekistiningsih   +1 more
doaj   +1 more source

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2012
Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy.
Diana Machado, Isabel Couto, João Perdigão, Liliana Rodrigues, Isabel Portugal, Pedro Baptista, Bruno Veigas, Leonard Amaral, Miguel Viveiros   +8 more
doaj   +1 more source

A four-month gatifloxacin-containing regimen for treating tuberculosis. [PDF]

, 2014
BACKGROUND: Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin ...
Amukoye, Evans, Bah, Boubacar, de Jong, Bouke C, Fielding, Katherine, Gninafon, Martin, Horton, John, Kassa, Ferdinand, Lapujade, Olivier, Lienhardt, Christian, Lo, Mame B, Merle, Corinne S, Mthiyane, Thuli, N'Diaye, Alimatou, Odhiambo, Joseph, OFLOTUB/Gatifloxacin for Tuberculosis Project, Olliaro, Piero L, Perronne, Christian, Rustomjee, Roxana, Sismanidis, Charalambos, Sow, Omou Bah   +19 more
core   +1 more source

Inhalable spray-dried chondroitin sulphate microparticles: effect of different solvents on particle properties and drug activity [PDF]

, 2020
Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles.
Buttini, Francesca, da Costa, Ana M Rosa, Faleiro, Maria Leonor, Flórez Fernández, Noelia, Grenha, Ana, Rodrigues, Susana, Torres, María Dolores   +6 more
core   +1 more source

A Radioimmunoassay for Isoniazid

Clinical Chemistry, 1975
Abstract A sensitive radioimmunoassay is described, for measuring isoniazid in therapeutic and subtherapeutic concentrations. This radioimmunoassay was used in an exploratory clinical study to measure, as a function of time, the concentration of this drug in plasma of patients receiving isoniazid therapy.
Kam S. Tse, K.A. Kelly, Alec H. Sehon, Robert Schwenk   +3 more
openaire   +3 more sources

Isoniazid causes heart looping disorder in zebrafish embryos by the induction of oxidative stress

BMC Pharmacology and Toxicology, 2020
Background The cardiotoxicity of isoniazid on zebrafish embryos and its underlying mechanism is unclear. Methods Here, we exposed zebrafish embryos at 4 h post-fertilization to different levels of isoniazid and recorded the morphology and number of ...
Jie Ni, Hongye Wang, Xiyi Wei, Kangjie Shen, Yeqin Sha, Yuxiang Dong, Yimei Shu, Xiaojie Wan, Jingwen Cheng, Fang Wang, Yihai Liu   +10 more
doaj   +1 more source

Rationing tests for drug-resistant tuberculosis - who are we prepared to miss? [PDF]

, 2016
BACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission.
A Faustini, A Pantoja, A Pooran, A Vassall, C Fitzpatrick, D Martínez, D Menzies, DAJ Moore, DAJ Moore, David A. J. Moore, E Tortoli, EA Kendall, EL Corbett, GJ Churchyard, JC Feres, Jon S. Friedland, Jorge Coronel, K Kliiman, KAK Angeby, L Caviedes, Laura J. Martin, Louis Grandjean, Luz Caviedes, MA Espinal, Martha H. Roper, O Oxlade, P Miotto, PG Suárez, PT Kent, Robert H. Gilman, SS Shin, V Boonsarngsuk, World Health Organization, World Health Organization, World Health Organization, World Health Organization   +35 more
core   +4 more sources

Poor Compliance Makes Treatment of Latent Tuberculosis Infection Unsatisfactory

Journal of Primary Care & Community Health, 2012
Objectives: The recommended treatment for latent tuberculosis infection is isoniazid for 9 months, but this regimen has a low completion rate. The authors wanted to compare treatment with isoniazid and treatment with isoniazid and rifampin in the typical
Panupong Larppanichpoonphol, Satish Bagdure, Hoda Mojazi Amiri, Kenneth Nugent   +3 more
doaj   +1 more source