Results 31 to 40 of about 87,478 (258)

Viewpoint: Scientific dogmas, paradoxes and mysteries of latent Mycobacterium tuberculosis infection [PDF]

, 2011
Worldwide, there are nearly 10 million new cases of active TB and 1.8 million associated deaths every year. WHO estimates that one-third of the world’s population is infected with Mycobacterium tuberculosis (Mtb), forming a huge latent Mtb global ...
Argyrou, Balasubramanian, Behar, Biketov, Corbett, Ehlers, Fraser, Grange, Henderson, Hernández-Pando, Honaker, Kang, Lin, Lobue, Mack, Marais, Migliori, Mitchison, Neyrolles, Opie, Parris, Stanford, Sterling, Sudre, Timmins, Vilchèze, WHO, WHO Report   +27 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Potential economic viability of two proposed rifapentine-based regimens for treatment of latent tuberculosis infection. [PDF]

PLoS ONE, 2011
Rifapentine-based regimens for treating latent tuberculosis infection (LTBI) are being considered for future clinical trials, but even if they prove effective, high drug costs may limit their economic viability.To inform clinical trial design by ...
David P Holland, Gillian D Sanders, Carol D Hamilton, Jason E Stout   +3 more
doaj   +1 more source

EFFECT OF PARACETAMOL ON THE RENAL CLEARANCE AND URINARY EXCRETION OF ISONIAZID IN GOATS [PDF]

Pakistan Veterinary Journal, 2009
Effect of paracetamol on renal clearance and urinary excretion of isoniazid was investigated in eight healthy adult female goats in two phases. In the first phase, each goat was administered isoniazid orally as a single dose at the rate of 10 mg/kg body ...
T. HUSSAIN, I. JAVED, F. H. KHAN, F. MUHAMMAD, B. ASLAM, S. AHMAD1, I. U. JAN2, A. BASIT AND U. TAHIR3
doaj  

Treatment outcomes and factors associated with unfavourable outcome among previously treated tuberculosis patients with isoniazid resistance in four regions of Cameroon

The Pan African Medical Journal, 2020
INTRODUCTION: It is unclear what the optimal treatment regimen for previously treated patients with rifampicin-susceptible isoniazid resistant tuberculosis should be. Conflicting evidence exists as to the effectiveness of the WHO standardized category II
Christopher Kuaban, Louise Daniele Ingrid Toukam, Melissa Sander   +2 more
doaj   +1 more source

EFFECTIVENESS OF COMBINATION OF ISONIAZID AND SILVER NANOPARTICLES IN THE TREATMENT OF EXPERIMENTAL TUBERCULOSIS

Туберкулез и болезни лёгких, 2017
Goal of the study: to investigate the impact  of isoniazid combined  with  silver nanoparticles on the isoniazid resistant strains  of tuberculous mycobacteria  and the course of experimental of tuberculosis  caused by the above strains.Materials and ...
A. V. Zаkhаrov, A. E. Ergeshov, A. L. Khokhlov, B. S. Kibrik   +3 more
doaj   +1 more source

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D., Buttini, Francesca, Cavaco, Joana S., Grenha, Ana, Guerreiro, Filipa, Pontes, Jorge Filipe, Rodrigues, Susana, Rosa Da Costa, Ana   +7 more
core   +1 more source

CYP2E1 and CYP2D6 in Anti-Tuberculosis Drug-Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications. [PDF]

Clin Transl Sci
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Prakongsup P, Udomsinprasert W.
europepmc   +2 more sources

Research Progress of isoniazid electrochemical sensors

Electrochemistry Communications
This paper reviews the research progress of isoniazid electrochemical sensors in recent years. As an important anti-tuberculosis drug, the rapid and sensitive detection of isoniazid is of great significance for clinical treatment and drug quality control.
Huanyu Che, Gaihua He, Xuekun Liu, Xin Guo, Chang Lei, Ye Liao   +5 more
doaj   +1 more source

Leptomeningitis in a person with radiologically isolated syndrome and latent tuberculosis. A case report with implications for clinical research [PDF]

, 2018
A 39-year-old man, followed with serial MRI of CNS for a radiologically isolate syndrome (RIS, a recently described condition considered a subclinical form of MS), was hospitalized for the occurrence of a leptomeningitis. Routine blood tests and contrast
Bozzao, Alessandro, Chiara Buscarinu, Maria, Ferraldeschi, Michela, Fornasiero, Arianna, Ristori, Giovanni, Romano, Andrea, Romano, Silvia, Salvetti, Marco, Teggi, Antonella   +8 more
core   +1 more source