Results 31 to 40 of about 86,651 (264)

The protective effect of lycopene against oxidative kidney damage associated with combined use of isoniazid and rifampicin in rats

Brazilian Journal of Medical and Biological Research, 2021
It is known that the combined use of antibiotics, such as isoniazid and rifampicin, in the treatment of tuberculosis causes oxidative kidney damage. The aim of this study was to biochemically and histopathologically investigate the effect of lycopene on ...
F. Bedir, H. Kocaturk, O. Turangezli, E. Sener, S. Akyuz, F.B. Ozgeris, B. Dabanlioglu, H. Suleyman, D. Altuner, B. Suleyman   +9 more
doaj   +1 more source

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance. [PDF]

, 2018
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available datasets describing its AMR characteristics demand disparate data-type analyses ...
Anand, Amitesh, Catoiu, Edward, Dillon, Nicholas, Heckmann, David, Kavvas, Erol S, Mih, Nathan, Monk, Jonathan M, Nizet, Victor, Palsson, Bernhard O, Seif, Yara, Yang, Laurence, Yurkovich, James T   +11 more
core   +2 more sources

Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy [PDF]

, 2016
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after ...
Anthony, Richard, Bratschi, Martin W., Cambau, Emmanuelle, Cavaliero, Arielle, Kasang, Christa, Mieras, Liesbeth, Perera, Geethal, Reichman, Lee, Richardus, Jan Hendrik, Saunderson, Paul, Steinmann, Peter, van Brakel, Wim, van den Broek, Jacques, Yew, Wing Wai   +13 more
core   +10 more sources

Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS

Molecules, 2022
Isoniazid and its metabolites are potentially associated with hepatotoxicity and treatment outcomes in patients who receive antituberculosis (TB) therapy.
Nguyen Ky Anh, Pham My Tung, Min Jung Kim, Nguyen Phuoc Long, Yong-Soon Cho, Dong-Hyun Kim, Jae-Gook Shin   +6 more
doaj   +1 more source

Protocol for a Case-Control Study to Investigate the Association of Pellagra With Isoniazid Exposure During Tuberculosis Preventive Treatment Scale-Up in Malawi

Frontiers in Public Health, 2020
Background: Pellagra is caused by niacin (vitamin B3) deficiency and manifested by a distinctive dermatitis. Isoniazid is critical for treating tuberculosis globally and is a component of most regimens to prevent tuberculosis. Isoniazid may contribute to
Scott A. Nabity, Kelvin Mponda, Steve Gutreuter, Diya Surie, Anne Williams, Anne Williams, Andrea J. Sharma, Elizabeth R. Schnaubelt, Rebekah E. Marshall, Hannah L. Kirking, Suzgo B. Zimba, Joram L. Sunguti, Laphiod Chisuwo, Mabvuto J. Chiwaula, Jesse F. Gregory, Robin da Silva, Michael Odo, Andreas Jahn, Thokozani Kalua, Rose Nyirenda, Belaineh Girma, James Mpunga, Nicole Buono, Alice Maida, Evelyn J. Kim, Laurence J. Gunde, Tigest F. Mekonnen, Andrew F. Auld, Adamson S. Muula, John E. Oeltmann   +29 more
doaj   +1 more source

Potential economic viability of two proposed rifapentine-based regimens for treatment of latent tuberculosis infection. [PDF]

PLoS ONE, 2011
Rifapentine-based regimens for treating latent tuberculosis infection (LTBI) are being considered for future clinical trials, but even if they prove effective, high drug costs may limit their economic viability.To inform clinical trial design by ...
David P Holland, Gillian D Sanders, Carol D Hamilton, Jason E Stout   +3 more
doaj   +1 more source

Breast tuberculosis in Northeast Iran: Review of 22 cases [PDF]

, 2014
Background: Breast tuberculosis (breast TB) is an extremely rare disease, so case reviews are also rare.Methods: This study is a retrospective review of patients with breast TB who were treated between 2002 and 2012 at the Health Center of Gorgan City ...
Khodabakhshi, B., Mehravar, F.
core   +2 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis

Emerging Infectious Diseases, 2006
In the context of tuberculosis (TB) resurgence, isoniazid preventive therapy (IPT) is increasingly promoted, but concerns about the risk for development of isoniazid-resistant tuberculosis may hinder its widespread implementation.
Maria Elvira Balcells, Sara L. Thomas, Peter Godfrey-Faussett, Alison D. Grant   +3 more
doaj   +1 more source

Leptomeningitis in a person with radiologically isolated syndrome and latent tuberculosis. A case report with implications for clinical research [PDF]

, 2018
A 39-year-old man, followed with serial MRI of CNS for a radiologically isolate syndrome (RIS, a recently described condition considered a subclinical form of MS), was hospitalized for the occurrence of a leptomeningitis. Routine blood tests and contrast
Bozzao, Alessandro, Chiara Buscarinu, Maria, Ferraldeschi, Michela, Fornasiero, Arianna, Ristori, Giovanni, Romano, Andrea, Romano, Silvia, Salvetti, Marco, Teggi, Antonella   +8 more
core   +1 more source