Results 21 to 30 of about 46,386 (217)

Protocol for a Case-Control Study to Investigate the Association of Pellagra With Isoniazid Exposure During Tuberculosis Preventive Treatment Scale-Up in Malawi

Frontiers in Public Health, 2020
Background: Pellagra is caused by niacin (vitamin B3) deficiency and manifested by a distinctive dermatitis. Isoniazid is critical for treating tuberculosis globally and is a component of most regimens to prevent tuberculosis. Isoniazid may contribute to
Scott A. Nabity, Kelvin Mponda, Steve Gutreuter, Diya Surie, Anne Williams, Anne Williams, Andrea J. Sharma, Elizabeth R. Schnaubelt, Rebekah E. Marshall, Hannah L. Kirking, Suzgo B. Zimba, Joram L. Sunguti, Laphiod Chisuwo, Mabvuto J. Chiwaula, Jesse F. Gregory, Robin da Silva, Michael Odo, Andreas Jahn, Thokozani Kalua, Rose Nyirenda, Belaineh Girma, James Mpunga, Nicole Buono, Alice Maida, Evelyn J. Kim, Laurence J. Gunde, Tigest F. Mekonnen, Andrew F. Auld, Adamson S. Muula, John E. Oeltmann   +29 more
doaj   +1 more source

EFFECT OF PARACETAMOL ON THE RENAL CLEARANCE AND URINARY EXCRETION OF ISONIAZID IN GOATS [PDF]

Pakistan Veterinary Journal, 2009
Effect of paracetamol on renal clearance and urinary excretion of isoniazid was investigated in eight healthy adult female goats in two phases. In the first phase, each goat was administered isoniazid orally as a single dose at the rate of 10 mg/kg body ...
T. HUSSAIN, I. JAVED, F. H. KHAN, F. MUHAMMAD, B. ASLAM, S. AHMAD1, I. U. JAN2, A. BASIT AND U. TAHIR3
doaj  

Research Progress of isoniazid electrochemical sensors

Electrochemistry Communications
This paper reviews the research progress of isoniazid electrochemical sensors in recent years. As an important anti-tuberculosis drug, the rapid and sensitive detection of isoniazid is of great significance for clinical treatment and drug quality control.
Huanyu Che, Gaihua He, Xuekun Liu, Xin Guo, Chang Lei, Ye Liao   +5 more
doaj   +1 more source

EFFECTIVENESS OF COMBINATION OF ISONIAZID AND SILVER NANOPARTICLES IN THE TREATMENT OF EXPERIMENTAL TUBERCULOSIS

Туберкулез и болезни лёгких, 2017
Goal of the study: to investigate the impact  of isoniazid combined  with  silver nanoparticles on the isoniazid resistant strains  of tuberculous mycobacteria  and the course of experimental of tuberculosis  caused by the above strains.Materials and ...
A. V. Zаkhаrov, A. E. Ergeshov, A. L. Khokhlov, B. S. Kibrik   +3 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19.

PLoS ONE, 2020
BackgroundPakistan is among top five high burden countries for tuberculosis and drug resistant TB. Among rifampicin sensitive new pulmonary TB (PTB), prevalence of isoniazid resistance is 8.3% (95%CI: 7.0-10.7) and resistance to fluoroquinolone is higher
Sabira Tahseen, Faisal Masood Khanzada, Alamdar Hussain Rizvi, Mahmood Qadir, Aisha Ghazal, Aurangzaib Quadir Baloch, Tehmina Mustafa   +6 more
doaj   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial

The Lancet Microbe, 2020
Summary: Background: Clinical studies suggest that isoniazid contributes rapid bacterial killing during the initial 2 days of tuberculosis treatment, but that the activity of isoniazid declines substantially after day 3 of treatment.
Andreas Diacon, ProfPhD, Sachiko Miyahara, PhD, Rodney Dawson, PhD, Xin Sun, PhD, Evelyn Hogg, Kathleen Donahue, MA, Michael Urbanowski, PhD, Veronique De Jager, MD, Courtney V Fletcher, ProfPharmD, Richard Hafner, MD, Susan Swindells, ProfMBBS, William Bishai, ProfMD   +11 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Lansoprazole Ameliorates Isoniazid-Induced Liver Injury

Pharmaceuticals
Isoniazid is a first-line drug in antitubercular therapy. Isoniazid is one of the most commonly used drugs that can cause liver injury or acute liver failure, leading to death or emergency liver transplantation.
Eri Wakai, Takashi Shiromizu, Shota Otaki, Junko Koiwa, Satoshi Tamaru, Yuhei Nishimura   +5 more
doaj   +1 more source