Results 71 to 80 of about 97,287 (310)

Rational Design and Antimycobacterial Evaluation of Aryl Sulfonamide–Linked Isoniazid Hydrazones Against Mycobacterium Tuberculosis

ChemMedChem, EarlyView.
Molecular docking shows that ligands 8 (a–i) adopt a U‐shaped geometry in the InhA active site, enabling stronger interactions than 7 (j–r). Surprisingly, both sets display similar potency, indicating that factors like electronic effects or solvation also influence anti‐TB activity.
Mukanda Gedeon Kadima, Sahil Mishra, Gobind Kumar, Pule Seboletswe, Afsana Kajee, Ankit, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Rajshekhar Karpoormath, Parvesh Singh   +10 more
wiley   +1 more source

Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug

Indonesian Journal of Chemistry, 2015
The aim of this research was to synthesize and characterize chitosan-calcium alginate as matrix isoniazid encapsulation to produce controlled release isoniazid drug.
Sari Edi Cahyaningrum, Nuniek Herdyastuti, Nur Qomariah   +2 more
doaj   +1 more source

New Structure Activity Relationship Insight into the Role of the C‐3 Extension on Rifamycin Antimycobacterial Activity

ChemMedChem, EarlyView.
Rifamycin analogues with variably functionalized C‐3 extensions provide new insight into the role of this region for MTb inhibitory activity. In addition to potentially optimizing target engagement, this region can also be used to modulate physicochemical properties, an important consideration for optimizing antimycobacterial activity.
Clinton G. L. Veale, Ewelina Smolarz, Aleksandra Leśniewska, Krystian Pyta, Piotr Przybylski   +4 more
wiley   +1 more source

ROLE OF PYRIDOXINE HYDROCHLORIDE IN THE DEVELOPMENT OF TOLERANCE TO THE TOXIC ACTION OF ISONIAZID IN ANIMALS

Туберкулез и болезни лёгких, 2018
The objective of the study: to assess the impact of continuous and course (intermittent) use of pyridoxine hydrochloride in combination with isoniazid on the rate of tolerance development in rats under conditions of a toxicological experiment.Subjects ...
K. I. Usov, T. A. Guskova, G. G. Yushkov
doaj   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Isoniazid-induced alopecia

Lung India, 2011
Isoniazid is a safe and very effective antituberculosis drug. Antimitotic agents routinely cause alopecia. Drug-induced alopecia is usually reversible upon withdrawal of the drug. Isoniazid, thiacetazone and ethionamide are the antituberculosis drugs which have been associated with alopecia.
K B Gupta, R Shandily, V Kumar, S Vishvkarma   +3 more
openaire   +4 more sources

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Rhabdomyolysis due to isoniazid poisoning resulting from the use of intramuscular pyridoxine

The Turkish Journal of Pediatrics, 2013
Isoniazid is an effective antituberculosis drug. Isoniazid poisoning produces a characteristic clinical syndrome that occurs 30 to 120 minutes after ingestion and includes seizures, metabolic acidosis, and in severe cases, coma.
Tuğba Eyüboğlu, Okşan Derinöz
doaj  

Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa [PDF]

, 2010
Tuberculosis (TB) remains a global emergency and is responsible for 1.7 million deaths annually. Widespread global misuse of isoniazid and rifampicin over three decades has resulted in emergence of the ominous spread of multidrug-resistant TB (MDR-TB ...
Abdool Karim, Amor, Balabanova, Caminero, Centers for Disease Control and Prevention, Chan, Chiang, Chiang, Chiang, Churchyard, Dheda, Dravniece, Dubrovina, Elliott, Espinal, Espinal, Espinal, Flament-Saillour, Gandhi, Gandhi, Gandhi, Goble, Grobusch, Habeenzu, Hoek, Holtz, Holtz, Iseman, Johnson, Kehinde, Kim, Kingkaew, Korenromp, Kranzer, Lalloo, Laserson, Lienhardt, Ma, Martin, Matteelli, Meskel, Migliori, Migliori, Migliori, Migliori, Migliori, Moore, Motus, O’Donnell, Pablos-Méndez, Pai, Park, Pietzka, Pillay, Quy, Saravia, Schaaf, Schaaf, Shah, Somocurcio, Sonnenberg, Sotgiu, Torun, Umubyeyi, Wallis, WHO, WHO, WHO and IUATLD, Wright, Wright, Zumla   +70 more
core   +1 more source

Optimal Seismic Design of High‐Rise Buildings With Outrigger Tuned Inertial Mass Damper

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper presents a novel optimization method for designing a system with a tuned inertial mass electromagnetic transducer (TIMET) damped outrigger (DO) for high‐rise buildings subjected to earthquakes. The DO system consists of the TIMET devices, which attach vertically between the outrigger and the perimeter columns.
Yanay Abrass, Oren Lavan
wiley   +1 more source