Results 71 to 80 of about 95,782 (307)

Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug

open access: yesIndonesian Journal of Chemistry, 2015
The aim of this research was to synthesize and characterize chitosan-calcium alginate as matrix isoniazid encapsulation to produce controlled release isoniazid drug.
Sari Edi Cahyaningrum   +2 more
doaj   +1 more source

Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report [PDF]

open access: yes, 2018
Rationale: Tuberculous meningitis is a highly morbid, often fatal disease. Patient concern: We describe a case of an Italian child. Diagnoses: we diagnosed early a Tuberculous meningitis complicated by the occurrence of hydrocephalus, stroke, and ...
Ajassa, Camilla   +8 more
core   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves   +3 more
wiley   +1 more source

ROLE OF PYRIDOXINE HYDROCHLORIDE IN THE DEVELOPMENT OF TOLERANCE TO THE TOXIC ACTION OF ISONIAZID IN ANIMALS

open access: yesТуберкулез и болезни лёгких, 2018
The objective of the study: to assess the impact of continuous and course (intermittent) use of pyridoxine hydrochloride in combination with isoniazid on the rate of tolerance development in rats under conditions of a toxicological experiment.Subjects ...
K. I. Usov, T. A. Guskova, G. G. Yushkov
doaj   +1 more source

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

open access: yesChemMedChem, EarlyView.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo   +6 more
wiley   +1 more source

Screening of Isoniazid Inactivators [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 1973
A method is described for phenotyping of isoniazid inactivators. After a test dose of isoniazid, free isoniazid and its acetyl derivative are estimated in urine by the same colorimetric reaction.
Leslie Eidus, Mary M. Hodgkin
openaire   +3 more sources

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano   +8 more
wiley   +1 more source

Rhabdomyolysis due to isoniazid poisoning resulting from the use of intramuscular pyridoxine

open access: yesThe Turkish Journal of Pediatrics, 2013
Isoniazid is an effective antituberculosis drug. Isoniazid poisoning produces a characteristic clinical syndrome that occurs 30 to 120 minutes after ingestion and includes seizures, metabolic acidosis, and in severe cases, coma.
Tuğba Eyüboğlu, Okşan Derinöz
doaj  

Isoniazid-induced alopecia

open access: yesLung India, 2011
Isoniazid is a safe and very effective antituberculosis drug. Antimitotic agents routinely cause alopecia. Drug-induced alopecia is usually reversible upon withdrawal of the drug. Isoniazid, thiacetazone and ethionamide are the antituberculosis drugs which have been associated with alopecia.
K B Gupta   +3 more
openaire   +4 more sources

DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection [PDF]

open access: yes, 2010
Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response.
Adams   +117 more
core   +1 more source

Home - About - Disclaimer - Privacy