Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 [PDF]
, 2008 The identification of potential new anti-tubercular cemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB).Libraries of NAS-21 and NAS-91 analogues were synthesized and ...
Besra, Gurdyal S +2 more
core +2 more sources
A four-month gatifloxacin-containing regimen for treating tuberculosis. [PDF]
, 2014 BACKGROUND: Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin ...
Amukoye, Evans +19 more
core +1 more source
Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N.
PLoS ONE, 2013 Isoniazid represents a first-line anti-tuberculosis medication in prevention and treatment. This prodrug is activated by a mycobacterial catalase-peroxidase enzyme called KatG in Mycobacterium tuberculosis), thereby inhibiting the synthesis of mycolic ...
Paolo Ascenzi +10 more
doaj +1 more source
Antituberculosis Activity of Brotowali (Tinospora Crispa) Extract and Fractions Against Mycobacterium Tuberculosis Using Microplate Alamar Blue Assay Method [PDF]
, 2017 Tuberculosis (TB), in which caused by pathogenic bacteria, Mycobacterium tuberculosis, has become the major causes of death among all of infectious diseases.
Irianti, T. (Tatang) +5 more
core
Tuberculous Pericarditis [PDF]
, 2018 info:eu-repo/semantics ...
Faria, D, Freitas, A
core +1 more source
MetalMat, EarlyView.This review provides the latest advancement on lead‐free all‐inorganic perovskites, covering fundamental aspects, emerging synthetic routes, and scintillation properties. We highlight the dopant engineering strategy to favor the formation and efficient radiative recombination of self‐trapped excitons and the future development direction for the next ...
Galfin Anderias Adu +6 more
wiley +1 more source
Impact of isoniazid monoresistance on overall and vulnerable patient populations in Taiwan
Emerging Microbes and InfectionsIsoniazid is an early bactericidal anti-tuberculosis (TB) agent and isoniazid mono-resistance TB is the most prevalent drug-resistant TB worldwide. Concerns exist regarding whether resistance to isoniazid would lead to delayed culture conversion and ...
Meng-Rui Lee +5 more
doaj +1 more source
Isoniazid-Induced Acute Psychosis in a Patient with Pleural Tuberculosis
Case Reports in Psychiatry, 2019 Tuberculosis is one of the top 10 causes of death and the leading cause from a single infectious agent (above HIV/AIDS). Isoniazid is highly bactericidal against replicating tubercle bacilli and is a component of all antituberculous chemotherapeutic ...
Joana Gomes +3 more
doaj +1 more source
Severe isoniazid related sideroblastic anemia
Hematology Reports, 2011 Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment.
Rein Jan Piso +2 more
doaj +1 more source
A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis. [PDF]
, 2017 Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases.
Catanzaro, A +7 more
core +1 more source